Výsledky vyhledávání - "Samina Y. Khan"

Supernatants and lipids from stored red blood cells activate pulmonary microvascular endothelium through the BLT2 receptor and protein kinase C activation

Autor: David J. Elzi, Samina Y. Khan, Anirban Banerjee, Kelly M. England, Susan Kuldanek, Christopher C. Silliman, F. Bernadette West, Jason Bjornsen, Nathan J. D. McLaughlin, Marguerite R. Kelher

Publikováno v: Transfusion. 57:2690-2700

BACKGROUND Although transfusion is a lifesaving intervention, it may be associated with significant morbidity in injured patients. We hypothesize that stored red blood cells (RBCs) induce proinflammatory activation of human pulmonary microvascular en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7274dfa6a8900ffb7d9a4b99defb21b
https://doi.org/10.1111/trf.14271

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Supernatants and lipids from stored red blood cells activate pulmonary microvascular endothelium through the BLT2 receptor and protein kinase C activation

Autor: Christopher C, Silliman, Marguerite R, Kelher, Samina Y, Khan, F Bernadette, West, Nathan J D, McLaughlin, David J, Elzi, Kelly, England, Jason, Bjornsen, Susan A, Kuldanek, Anirban, Banerjee

Publikováno v: Transfusion. 57(11)

Although transfusion is a lifesaving intervention, it may be associated with significant morbidity in injured patients. We hypothesize that stored red blood cells (RBCs) induce proinflammatory activation of human pulmonary microvascular endothelial c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1b145dfd669a0026254232da05c79539
https://pubmed.ncbi.nlm.nih.gov/28880373

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Experimental prestorage filtration removes antibodies and decreases lipids in RBC supernatants mitigating TRALI in vivo

Autor: Barbara Mish, Samuel O. Sowemimo-Coker, Kevin J Land, Monica LaSarre, Samina Y. Khan, Christopher C. Silliman, Linda Ceriano, F. Bernadette West, Marguerite R. Kelher

Publikováno v: Blood. 123:3488-3495

Transfusion-related acute lung injury (TRALI) remains a significant cause of transfusion-related mortality with red cell transfusion. We hypothesize that prestorage filtration may reduce proinflammatory activity in the red blood cell (RBC) supernatan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e6c14ea02823a2382a8e142dc48de746
https://doi.org/10.1182/blood-2013-10-532424

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LysoPCs induce Hck- and PKCδ-mediated activation of PKCγ causing p47phox phosphorylation and membrane translocation in neutrophils

Autor: Christopher C. Silliman, Xianzhong Meng, Nathan J. D. McLaughlin, Marguerite R. Kelher, Anirban Banerjee, Sanchayita Mitra, Fabia Gamboni, Samina Y. Khan, David J. Elzi

Lysophosphatidylcholines (lysoPCs) are effective polymorphonuclear neutrophil (PMN) priming agents implicated in transfusion-related acute lung injury (TRALI). LysoPCs cause ligation of the G2A receptor, cytosolic Ca2+ flux, and activation of Hck. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::726f8e1e665ae4479f2808bb779d2c42
https://europepmc.org/articles/PMC5166440/

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Biological response modifiers in photochemically pathogen-reduced versus untreated apheresis platelet concentrates

Autor: Samina Y. Khan, Annette Vetlesen, Mohammad Reza Mirlashari, Çiğdem Akalın Akkök, Christopher C. Silliman, Jens Kjeldsen-Kragh, Marguerite R. Kelher

Publikováno v: Transfusion. 53:147-155

The platelet storage lesion (PSL) is a term often used for the sum of the deleterious changes in structure and function that occur to platelets (PLTs) in platelet concentrates (PCs) during storage under blood bank conditions. One of the features of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc2d5e354114624936d2e10b9ea7d5ce
https://doi.org/10.1111/j.1537-2995.2012.03681.x

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The pro-inflammatory effects of platelet contamination in plasma and mitigation strategies for avoidance

Autor: Christopher C. Silliman, Samina Y. Khan, Marguerite R. Kelher, Travis H. Berry, Rachel S. Bercovitz, Kevin J Land

Publikováno v: Vox Sanguinis. 102:345-353

Background and Objectives Plasma and platelet concentrates are disproportionately implicated in transfusion-related acute lung injury (TRALI). Platelet-derived pro-inflammatory mediators, including soluble CD40 ligand (sCD40L), accumulate during stor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d61e53965e0a9fac44e54537e6a018d9
https://doi.org/10.1111/j.1423-0410.2011.01559.x

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Identification of lipids that accumulate during the routine storage of prestorage leukoreduced red blood cells and cause acute lung injury

Autor: Christopher C. Silliman, Marguerite R. Kelher, Samina Y. Khan, Lauren Gellar, Ernest E. Moore, David J. Elzi

Publikováno v: Transfusion. 51:2549-2554

Transfusion-related acute lung injury (TRALI) remains the most common cause of transfusion-related mortality.1,2 TRALI has been linked to a number of mediators including antibodies against white blood cell (WBC) antigens, biologically active lipids t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8481bf3009c80b5d30ae66ea09236b5
https://doi.org/10.1111/j.1537-2995.2011.03186.x

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Leukotriene B4 and its Metabolites Prime the Neutrophil Oxidase and Induce Proinflammatory Activation of Human Pulmonary Microvascular Endothelial Cells

Autor: John C. Eun, Anirban Banerjee, Marguerite R. Kelher, David J. Elzi, Nathan J. D. McLaughlin, Christopher C. Silliman, Ernest E. Moore, Samina Y. Khan

Publikováno v: Shock. 35:240-244

Leukotrienes are proinflammatory lipid mediators, derived from arachidonic acid via 5-lipoxygenase (5-LO). Leukotriene B4 (LTB4) is an effective polymorphonuclear neutrophil (PMN) chemoattractant, as well as being a major product of PMN priming. Leuk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a1f269850251136a2da264aef0d1b75
https://doi.org/10.1097/shk.0b013e3181faceb3

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Lysophosphatidylcholines activate G2A inducing Gαi-1-/Gαq/11- Ca2+ flux, Gβγ-Hck activation and clathrin/β-arrestin-1/GRK6 recruitment in PMNs

Autor: Samina Y. Khan, Anirban Banerjee, Marguerite R. Kelher, Phillip Eckels, Christopher C. Silliman, Fabia Gamboni-Robertson, Nathan J. D. McLaughlin

Publikováno v: Biochemical Journal. 432:35-45

Lyso-PCs (lysophosphatidylcholines) are a mixture of lipids that accumulate during storage of cellular blood components, have been implicated in TRALI (transfusion-related acute lung injury) and directly affect the physiology of neutrophils [PMNs (po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d1e0f983986b818a12aa1f8cccea9596
https://doi.org/10.1042/bj20091087

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Mirasol Pathogen Reduction Technology®treatment does not affect acute lung injury in a two-event in vivo model caused by stored blood components

Autor: Samina Y. Khan, J. Bradley Ball, Christopher C. Silliman, Marguerite R. Kelher, S. Marschner

Publikováno v: Vox Sanguinis. 98:525-530

Introduction Mirasol Pathogen Reduction Technology® (PRT) treatment uses riboflavin and UV light to inactivate pathogens in blood components. Neutrophil [polymorphonuclear cells (PMN)] priming activity accumulates during routine storage of cellular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0246775cc2fd502e24820e3a87ff9e1
https://doi.org/10.1111/j.1423-0410.2009.01289.x

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