Výsledky vyhledávání - "Samiksha Giri"

Akademický článek

The double-hit protocol induces HFpEF and impairs myocardial ubiquitin-proteasome system performance in FVB/N mice

Autor: Jose R. Lira, Andrew L. Guymon, Liuqing Yang, Jack O. Sternburg, Samiksha Giri, Xuejun Wang

Publikováno v: Frontiers in Physiology, Vol 14 (2023)

Heart failure with preserved ejection fraction (HFpEF) is a leading cause of death and disability, with its prevalence surpassing that of heart failure with reduced ejection fraction. Obesity and hypertension are often associated with HFpEF. HFpEF ca

Externí odkaz: https://doaj.org/article/74e6576a11474107babe07ac27a087da

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COP9 Signalosome Promotes Neointimal Hyperplasia via Deneddylation and CSN5-Mediated Nuclear Export

Autor: Samiksha Giri, Chao Suo, Ruggero Pardi, Gregory A. Fishbein, Khosrow Rezvani, Yabing Chen, Xuejun Wang

Publikováno v: bioRxiv

BACKGROUNDNeointimal hyperplasia (NH) is a common pathological response to vascular injury and mediated primarily by vascular smooth muscle cell (VSMC) migration and proliferation. The COP9 signalosome (CSN) is formed by 8 canonical subunits (CSN1 th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb083d230d52998a3a6bcb9b88ca7d5
https://europepmc.org/articles/PMC10120714/

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Abstract 191: Cops5-mediated Nuclear Exclusion Of P27 Is Responsible For The Promotion Of Vascular Smooth Muscle Cells Proliferation By Cops8 Hypomorphism

Autor: Samiksha Giri, Chao Suo, Douglas S Martin, Xuejun Wang

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 42

Background: The COP9 signalosome (CSN) holocomplex is formed by 8 stoichiometric protein subunits: COPS1 through COPS8. Despite the strong evidence linking CSN to cell cycle regulation, direct study of CSN in VSMC proliferation is lacking. Our prior

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e37462b373ee7e2ce42f5b65c459813
https://doi.org/10.1161/atvb.42.suppl_1.191

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CSN5‐mediated nuclear exclusion of p27 in vascular smooth muscle cells contributes to the exacerbation of neointimal hyperplasia by CSN8 hypomorphism

Autor: Samiksha Giri, Chao Suo, Douglas Martin, Xuejun Wang

Publikováno v: The FASEB Journal. 36

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f11f9af67ac21dc187b808a5781e415
https://doi.org/10.1096/fasebj.2022.36.s1.r4622

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Defining Molecular Mechanism Promoting Neointimal Hyperplasia by CSN8 Hypomorphism

Autor: Douglas S. Martin, Xuejun Wang, Samiksha Giri, Chao Suo

Publikováno v: The FASEB Journal. 35

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05d1b260d6096a7d09ebbfc03b3e70da
https://doi.org/10.1096/fasebj.2021.35.s1.04143

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