Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Samih Alqawlaq"'
Autor:
Xiaoxin Guo, Qi Jiang, Alessandra Tuccitto, Darren Chan, Samih Alqawlaq, Gah-Jone Won, Jeremy M. Sivak
Publikováno v:
Neurobiology of Disease, Vol 113, Iss , Pp 59-69 (2018)
Neurons are highly sensitive to metabolic and oxidative injury, but endogenous astrocyte mechanisms have a critical capacity to provide protection from these stresses. We previously reported that the master regulator PGC-1α (peroxisome proliferator-
Externí odkaz:
https://doaj.org/article/25a89ad48ecc40eb968604878148a8ec
Autor:
Nafiseh Nafissi, Samih Alqawlaq, Eric A Lee, Marianna Foldvari, Paul A Spagnuolo, Roderick A Slavcev
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 3, Iss C (2014)
Conventional plasmid DNA vectors play a significant role in gene therapy, but they also have considerable limitations: they can elicit adverse immune responses because of bacterial sequences they contain for maintenance and amplification in prokaryot
Externí odkaz:
https://doaj.org/article/6a399a0a86e74335a443505552161db8
Publikováno v:
Experimental Eye Research. 183:88-97
Glaucoma describes a distinct optic neuropathy with complex etiology and a variety of associated risk factors, but with similar pathological endpoints. Risk factors such as age, increased intraocular pressure (IOP), low mean arterial pressure, and au
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a66eb16fd906a9cbf06c56a860962b
https://doi.org/10.1016/j.exer.2018.11.005
https://doi.org/10.1016/j.exer.2018.11.005
Autor:
Gerold Schmitt-Ulms, Samih Alqawlaq, Joseph D'Ercole, Anita H. Corbett, Declan Williams, Jeffrey L. Wrana, Alessandro Datti, Darren Chan, Sara W. Leung, Jeremy M Sivak, Alessandra Tuccitto, Izhar Livne-Bar
Publikováno v:
The Journal of Biological Chemistry
Astrocytes can support neuronal survival through a range of secreted signals that protect against neurotoxicity, oxidative stress, and apoptotic cascades. Thus, analyzing the effects of the astrocyte secretome may provide valuable insight into these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953c9e8f597c65180ef16f8a53ffa261
http://europepmc.org/articles/PMC7948738
http://europepmc.org/articles/PMC7948738
Autor:
Qi Jiang, Darren Chan, Alessandra Tuccitto, Xiaoxin Guo, Samih Alqawlaq, Jeremy M Sivak, Gah-Jone Won
Publikováno v:
Neurobiology of Disease, Vol 113, Iss, Pp 59-69 (2018)
Neurons are highly sensitive to metabolic and oxidative injury, but endogenous astrocyte mechanisms have a critical capacity to provide protection from these stresses. We previously reported that the master regulator PGC-1α (peroxisome proliferator-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3637afc08cb1d8a407041371f70ce79
http://www.sciencedirect.com/science/article/pii/S0969996118300366
http://www.sciencedirect.com/science/article/pii/S0969996118300366
Autor:
Jeremy M Sivak, Karsten Gronert, Alessandra Tuccitto, Jessica Wei, Hsin-Hua Liu, John G. Flanagan, Gah-Jone Won, Izhar Livne-Bar, Samih Alqawlaq
Publikováno v:
The Journal of clinical investigation, vol 127, iss 12
Astrocytes perform critical non-cell autonomous roles following CNS injury that involve either neurotoxic or neuroprotective effects. Yet the nature of potential prosurvival cues has remained unclear. In the current study, we utilized the close inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6140fe07154fe503925d8e7096bce70
https://escholarship.org/uc/item/2wx8r26p
https://escholarship.org/uc/item/2wx8r26p
Publikováno v:
Nanomedicine. 7:1067-1083
Over the past decade the application of gene therapy of retinal diseases such as glaucoma has produced promising results. However, optic nerve regeneration and restoration of vision in patients with glaucoma is still far from reality. Neuroprotective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aba2f060e4a9f7b05f298fc32650d06f
https://doi.org/10.2217/nnm.12.69
https://doi.org/10.2217/nnm.12.69
Autor:
Marianna Foldvari, J. Torin Huzil, Michael A. Beazely, Samih Alqawlaq, Marina V. Ivanova, Jeremy M Sivak, John G. Flanagan
Publikováno v:
Nanomedicine : nanotechnology, biology, and medicine. 10(8)
Gene therapy could offer improvement in the treatment of glaucoma compared to the current standard of lowering intraocular pressure. We have developed and characterized non-viral gemini surfactant-phospholipid nanoparticles (GL-NPs) for intravitreal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65fb03b5d0a903542ea53da11bcd5dd6
https://pubmed.ncbi.nlm.nih.gov/24905400
https://pubmed.ncbi.nlm.nih.gov/24905400
Publikováno v:
Journal of Vision. 7:114-114
In many natural scenes, shadows and shading, which are primarily luminance-defined features, proliferate. Hence one might expect that the chromatic variations of natural scenes, which more faithfully represent the layout of object surfaces, will cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1230e6225beb09e58d54fcb783b7885b
https://doi.org/10.1167/7.15.114
https://doi.org/10.1167/7.15.114