Zobrazeno 1 - 10
of 219
pro vyhledávání: '"Samie R, Jaffrey"'
Autor:
Zhongxuan Zhang, Xiaoxiao Rong, Tianjin Xie, Zehao Li, Haozhi Song, Shujun Zhen, Haifeng Wang, Jiahui Wu, Samie R. Jaffrey, Xing Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Genomic DNA exhibits high heterogeneity in terms of its dynamic within the nucleus, its structure and functional roles. CRISPR-based imaging approaches can image genomic loci in living cells. However, conventional CRISPR-based tools involve
Externí odkaz:
https://doaj.org/article/945f65ff84cb4993989a41334a52dd60
Autor:
Qian Hou, Samie R. Jaffrey
Publikováno v:
RNA Biology, Vol 20, Iss 1, Pp 198-206 (2023)
RNA aptamers are structured RNAs that can bind to diverse ligands, including proteins, metabolites, and other small molecules. RNA aptamers are widely used as in vitro affinity reagents. However, RNA aptamers have not been highly successful as bioact
Externí odkaz:
https://doaj.org/article/12a5e1b8b2a94a93b8388256b536cc86
Autor:
Luiz F. M. Passalacqua, Mary R. Starich, Katie A. Link, Jiahui Wu, Jay R. Knutson, Nico Tjandra, Samie R. Jaffrey, Adrian R. Ferré-D’Amaré
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Beetroot is a homodimeric in vitro selected RNA that binds and activates DFAME, a conditional fluorophore derived from GFP. It is 70% sequence-identical to the previously characterized homodimeric aptamer Corn, which binds one molecule of it
Externí odkaz:
https://doaj.org/article/d5c0aa19bfa048f0b1fc7d7019110d05
Autor:
Peng Han, Yuanchu She, Zhuoxuan Yang, Mengru Zhuang, Qingjun Wang, Xiaopeng Luo, Chaoqun Yin, Junda Zhu, Samie R Jaffrey, Sheng-Jian Ji
Publikováno v:
PLoS Biology, Vol 20, Iss 11, p e3001853 (2022)
The accurate construction of neural circuits requires the precise control of axon growth and guidance, which is regulated by multiple growth and guidance cues during early nervous system development. It is generally thought that the growth and guidan
Externí odkaz:
https://doaj.org/article/90c0475399e54fd0abc0ac2e9088ebd6
Publikováno v:
PLoS Biology, Vol 20, Iss 7 (2022)
N6-methyladenosine (m6A) is a highly prevalent mRNA modification that promotes degradation of transcripts encoding proteins that have roles in cell development, differentiation, and other pathways. METTL3 is the major methyltransferase that catalyzes
Externí odkaz:
https://doaj.org/article/92d33866c3c94ff8937d6d8480ade45e
Autor:
Sameer Dixit, Samie R Jaffrey
Publikováno v:
PLoS Biology, Vol 20, Iss 7, p e3001720 (2022)
Nucleotide modifications can markedly influence mRNA processing and metabolism. New studies, one in PLOS Biology, show that approximately 130 yeast mRNAs contain dihydrouridine, a derivative of uridine. Functional studies show that dihydrouridine, in
Externí odkaz:
https://doaj.org/article/9659816987b74f33bceb320ee4bf2c8b
Autor:
Jacob L, Litke, Samie R, Jaffrey
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2570
RNA aptamers can be genetically encoded in cells to probe and manipulate cellular function. The usefulness of aptamers in mammalian cells is limited by low accumulation and degradation by ribonucleases. Expression of circular RNA aptamers using the T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b30fb99a6a848a193f99e693fde142ed
https://pubmed.ncbi.nlm.nih.gov/36156786
https://pubmed.ncbi.nlm.nih.gov/36156786
Autor:
Anya V. Grozhik, Anthony O. Olarerin-George, Miriam Sindelar, Xing Li, Steven S. Gross, Samie R. Jaffrey
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
N 1-methyladenosine (m1A) was recently reported as a new mRNA modification but its prevalence has been controversial. Here the authors showed that m1A, if present in mRNA, is at very low stoichiometry, with the notable exception of MT-ND5. Further, t
Externí odkaz:
https://doaj.org/article/9b5c924dc48f490aafd659539f03fc90
Autor:
Liang Zhou, Wenjun Yu, David S. Jayabalan, Ruben Niesvizky, Samie R. Jaffrey, Xiangao Huang, Guoqiang Xu
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Cereblon (CRBN), a substrate receptor of cullin 4-RING E3 ligase (CRL4), mediates the ubiquitination and degradation of constitutive substrates and immunomodulatory drug-induced neo-substrates including MEIS2, c-Jun, CLC1, IKZF1/3, CK1α, and SALL4.
Externí odkaz:
https://doaj.org/article/b10148d706b0477191947d287465021d
Autor:
Vladimir Despic, Samie R. Jaffrey
Publikováno v:
Nature. 614:358-366
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5dd96b1d09091f2f9934db06a57d4d0
https://doi.org/10.1038/s41586-022-05668-z
https://doi.org/10.1038/s41586-022-05668-z