Výsledky vyhledávání - "Samia M. Mostafa"

Akademický článek

Design, synthesis and antitumor evaluation of novel pyrazolo[3,4-d]pyrimidines incorporating different amino acid conjugates as potential DHFR inhibitors

Autor: Ibrahim M. Salem, Samia M. Mostafa, Ismail Salama, Osama I. El-Sabbagh, Wael A. H. Hegazy, Tarek S. Ibrahim

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1, Pp 203-215 (2023)

The present study aimed to investigate the antitumor effect of simultaneous inhibition of dihydrofolate reductase (DHFR) enzyme. We designed some novel pyrazolo[3,4-d]pyrimidines bearing different amino acid conjugates as efficient antifolate agents

Externí odkaz: https://doaj.org/article/1b9871a7e6654342ab9bfdb2571fcd71

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Akademický článek

Design, Synthesis, Anticancer Activity, and Solid Lipid Nanoparticle Formulation of Indole- and Benzimidazole-Based Compounds as Pro-Apoptotic Agents Targeting Bcl-2 Protein

Autor: Manar I. Nagy, Khaled M. Darwish, Safaa M. Kishk, Mohamed A. Tantawy, Ali M. Nasr, Mona Qushawy, Shady A. Swidan, Samia M. Mostafa, Ismail Salama

Publikováno v: Pharmaceuticals, Vol 14, Iss 2, p 113 (2021)

Cancer is a multifactorial disease necessitating identification of novel targets for its treatment. Inhibition of Bcl-2 for triggered pro-apoptotic signaling is considered a promising strategy for cancer treatment. Within the current work, we aimed t

Externí odkaz: https://doaj.org/article/4482304dbd5145bd9c684ab0215768ba

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Akademický článek

The Anticancer Activity for the Bumetanide-Based Analogs via Targeting the Tumor-Associated Membrane-Bound Human Carbonic Anhydrase-IX Enzyme

Autor: Azizah M. Malebari, Tarek S. Ibrahim, Ibrahim M. Salem, Ismail Salama, Ahdab N. Khayyat, Samia M. Mostafa, Osama I. El-Sabbagh, Khaled M. Darwish

Publikováno v: Pharmaceuticals, Vol 13, Iss 9, p 252 (2020)

The membrane-bound human carbonic anhydrase (hCA) IX is widely recognized as a marker of tumor hypoxia and a prognostic factor within several human cancers. Being undetected in most normal tissues, hCA-IX implies the pharmacotherapeutic advent of red

Externí odkaz: https://doaj.org/article/fcdfe9a1869a45d992debe0daab6b0fa

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Design, synthesis and antitumor evaluation of novel pyrazolo[3,4-d]pyrimidines incorporating different amino acid conjugates as potential DHFR inhibitors

Autor: Ibrahim M. Salem, Samia M. Mostafa, Ismail Salama, Osama I. El-Sabbagh, Wael A. H. Hegazy, Tarek S. Ibrahim

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry. 38:203-215

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dafdee3807251b05e231da7c45135e53
https://doi.org/10.1080/14756366.2022.2142786

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Simultaneous Determination of Losartan and Rosuvastatin in Rat Plasma Using Liquid Chromatography–Tandem Mass Spectrometric Technique for Application into Pharmacokinetic and Drug–Drug Interaction Studies

Autor: Mohamed Saleh Elgawish, Khaled M. Darwish, Safaa M. Kishk, Magdy Atef Wadie, Samia M. Mostafa

Publikováno v: Chromatographia. 83:1477-1494

The combined therapy benefits of losartan and rosuvastatin, within the vascular injury, have been well characterized. Nonetheless, the pharmacokinetic interactions between such therapeutic agents have not been yet figured out, making the need for a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::083ace7d132a39d067ff1261fe2a78f4
https://doi.org/10.1007/s10337-020-03967-z

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Human dihydrofolate reductase inhibition effect of 1-Phenylpyrazolo[3,4–d]pyrimidines: Synthesis, antitumor evaluation and molecular modeling study

Autor: Ibrahim M, Salem, Samia M, Mostafa, Ismail, Salama, Osama I, El-Sabbagh, Wael, A H Hegazy, Tarek S, Ibrahim

Publikováno v: Bioorganic Chemistry. 129:106207

A new series of pyrazolo[3,4-d]pyrimidine analogues bearing different amino acid conjugates 10suba-m/subwere synthesized with the aim to evaluate their antitumor effect through simultaneous inhibition of human dihydrofolate reductase (hDHFR). All nov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0af155adf73bd826aa4ab2d5f74dac
https://doi.org/10.1016/j.bioorg.2022.106207

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Liquid chromatography tandem mass spectrometry for the simultaneous determination of metformin and pioglitazone in rat plasma: Application to pharmacokinetic and drug-drug interaction studies

Autor: Mohamed Saleh Elgawish, Sally Nasser, Abbas M. Abbas, Samia M. Mostafa, Ismail Salama

Publikováno v: Journal of Chromatography B. 1124:47-57

Failure to attain and sustain long term glycemic control is an ongoing challenge in diabetes therapy. The trend to use a combined therapy and the risk of drug-drug interaction (DDI) are elevated and thus the need for sensitive analytical methods is o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::551e2290144fe9e1ce9e0b97321f0ec6
https://doi.org/10.1016/j.jchromb.2019.05.036

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Development and validation of an HPLC-UV method for simultaneous determination of sildenafil and tramadol in biological fluids: Application to drug-drug interaction study

Autor: Mohamed A. Helal, Samia M. Mostafa, Hosam Eldin Dahshan, Mohamed Saleh Elgawish

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 168:201-208

The introduction of sildenafil (SDF) to treat erectile dysfunction has solved a widespread condition with negative on the quality of life. Recently, the co-administration of tramadol (TMD) with SDF to manage premature ejaculation has illegally increa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed5839b28e7d3ba44dbf4ea029f2ffd1
https://doi.org/10.1016/j.jpba.2019.02.025

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Comparative high-performance liquid chromatographic and high-performance thin-layer chromatographic study for the simultaneous determination of dapagliflozin and metformin hydrochloride in bulk and pharmaceutical formulation

Autor: Sally Nasser, Samia M. Mostafa, Ismail Salama, Mohamed Saleh Elgawish

Publikováno v: JPC - Journal of Planar Chromatography - Modern TLC. 31:469-476

The discovery of potent antidiabetic drugs is of necessity owing to the rapid prevalence of diabetes worldwide. The investigation of a new separation method for the simultaneous determination of combined antidiabetic drugs is thus an essential issue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb9dc9f9027b2ea60a9dab91a552b137
https://doi.org/10.1556/1006.2018.31.6.7

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