Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Samia A. Elseginy"'
Autor:
Samia A. Elseginy, Manal M. Anwar
Publikováno v:
ACS Omega, Vol 7, Iss 1, Pp 1150-1164 (2021)
Externí odkaz:
https://doaj.org/article/fd9121d87d924c55a6f8f5bd35a45801
Autor:
Rania Hamdy, Samia A. Elseginy, Noha I. Ziedan, Mohamed El-Sadek, Elsaid Lashin, Arwyn T. Jones, Andrew D. Westwell
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 23, p 8980 (2020)
A series of 2-(1H-indol-3-yl)-5-substituted-1,3,4-oxadiazoles, 4a–m, were designed, synthesized and tested in vitro as potential pro-apoptotic Bcl-2 inhibitory anticancer agents based on our previously reported hit compounds. Synthesis of the targe
Externí odkaz:
https://doaj.org/article/44829c0c0c0b4856acfe0d26be4756ad
Publikováno v:
Molecules, Vol 24, Iss 7, p 1274 (2019)
The Bcl-2 protein has been studied as an anticancer drug target in recent years, due to its gatekeeper role in resisting programmed cancer cell death (apoptosis), and the design of BH3 domain mimetics has led to the clinical approval of Venetoclax (A
Externí odkaz:
https://doaj.org/article/5b45fe5be63546acaf769bcb3d868c40
Autor:
Samia A. Elseginy
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 40:13658-13674
The outbreak caused by a coronavirus 2 has required quick and potential treatment strategies. The main protease enzyme Mpro plays an important role in the viral replication which renders it an impo...
Publikováno v:
Elseginy, S A, Oliveira, S, Shoemark, D K & Sessions, R B 2022, ' Identification and validation of novel microtubule suppressors with an imidazopyridine scaffold through structure-based virtual screening and docking ', RSC medicinal chemistry, vol. 13, no. 8, pp. 929-943 . https://doi.org/10.1039/D1MD00392E
Targeting the colchicine binding site of α/β tubulin microtubules can lead to suppression of microtubule dynamics, cell cycle arrest and apoptosis. Therefore, the development of microtubule (MT) inhibitors is considered a promising route to antican
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::548d2e2b29d45180b670ba1a6be51b5c
https://research-information.bris.ac.uk/ws/files/333784347/d1md00392e.pdf
https://research-information.bris.ac.uk/ws/files/333784347/d1md00392e.pdf
Autor:
Manal M. Anwar, Somaia S. Abd El-Karim, Basma M. Essa, Samia A. Elseginy, Tamer M. Sakr, Yasmin M. Syam
Publikováno v:
RSC Advances. 11:36989-37010
The current work represents the design and synthetic approaches of a new set of compounds 6–10 bearing the 1,4-dimethyl-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide scaffold. The biological evaluation revealed that most of the new compound
Autor:
Samia A. Elseginy, Manal M. Anwar
Publikováno v:
RSC Advances. 11:38616-38631
The emergent outbreak caused by severe acute respiratory syndrome coronavirus 2 continues spreading and causing huge social and economic disruption. Papain-like protease (PLpro) has a crucial role in the cleavage of viral polyproteins, and disruption
Autor:
Ghada E. A. Awad, Eman R. Kotb, Yasmin M. Syam, Manal M. Anwar, Hanem M. Awad, Samia A. Elseginy
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 19:1255-1275
Objective & Methodology: New hybrids of thiopyrimidine-five/six heterocyclic rings were synthesized and in vitro evaluated for their antiproliferative activity against three human cancer cell lines, namely HCT116 (human colorectal carcinoma), PC-3 (h
Autor:
Sameh S. M. Soliman, Bahgat Fayed, Rania Hamdy, Ahmed M. Almehdi, Samia A. Elseginy, Noura Mahrous, Ahmed Mostafa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Graphical abstract
SARS-CoV-2 caused dramatic health, social and economic threats to the globe. With this threat, the expectation of future outbreak, and the shortage of anti-viral drugs, scientists were challenged to develop novel antivirals. T
SARS-CoV-2 caused dramatic health, social and economic threats to the globe. With this threat, the expectation of future outbreak, and the shortage of anti-viral drugs, scientists were challenged to develop novel antivirals. T
Autor:
Sameh S. M. Soliman, Rania Hamdy, Samia A. Elseginy, Balsam Qubais Saeed, Ali El-Keblawy, Farah Al-Marzooq, Islam M. Ahmady
Publikováno v:
Chemico-biological interactions. 333
Antimicrobial resistance is at increasing risk worldwide since it is threatening the ability to control common infectious diseases, resulting in prolonged illness, disability, and death. Herein, we inspired by the effective plant phytochemical mechan