Hypothyroidism increases angiotensinogen gene expression associated with vascular smooth muscle cells cholesterol metabolism dysfunction and aorta remodeling in Psammomys obesus

Autor: Samia Neggazi, Nadjiba Hamlat, Sihem Berdja, Saliha Boumaza, Leila Smail, Michel Beylot, Souhila Aouichat-Bouguerra

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)

Abstract It has been previously shown that clinical cardiovascular manifestations can be caused by mild changes in thyroid function. However, the implication of angiotensinogen (Agt) and vascular smooth muscle cells (VSMCs) dysfunction in the pathoph

Externí odkaz: https://doaj.org/article/efaacb9dc507435fb24c4e4c14cd37d1

Scolymus hispanicus (Golden Thistle) Ameliorates Hepatic Steatosis and Metabolic Syndrome by Reducing Lipid Accumulation, Oxidative Stress, and Inflammation in Rats under Hyperfatty Diet

Autor: El-mehdi Haffaf, Leila Smail, Samia Neggazi, Abdelhamid Sahraoui, Lynda Boudarene, Ghouti Kacimi, Sihem Berdja, Saliha Boumaza, Souhila Aouichat Bouguerra

Publikováno v: Evidence-based Complementary and Alternative Medicine : eCAM
Evidence-Based Complementary and Alternative Medicine, Vol 2021 (2021)

Background. Lipotoxicity is characterized by a metabolic disturbance leading to the development of nonalcoholic fatty liver disease (NAFLD). Some medicinal plant extracts exert hepatoprotective activity by modulating oxidative stress, inflammation, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a224d36647fb399dd13791d545c3b2
http://europepmc.org/articles/PMC8289590

Therapeutic effect of aqueous extract of Globularia alypum following in vitro insulin induced toxicity on Rattus norvegicus cardiomyocytes

Autor: Lynda Boudarene, Souhila Aouichat Bouguerra, Sihem Berdja, Saka Boualem, Saliha Boumaza, Samia Neggazi, Ghouti Kacimi, Leila Smail

Publikováno v: Nutrition & Santé. :27-35

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::092106189443e75400f608f6fdbf2262
https://doi.org/10.30952/ns.6.1.4

TRα inhibits arterial renin-angiotensin system expression and prevents cholesterol accumulation in vascular smooth muscle cells

Autor: Giampiero Bricca, Karine Gauthier, Souhila Aouichat-Bouguerra, Laurence Canaple, Michel Beylot, Jacques Samarut, Samia Neggazi, Nadjiba Hamlat

Publikováno v: Annales d'Endocrinologie
Annales d'Endocrinologie, 2019, 80 (2), pp.89-95. ⟨10.1016/j.ando.2018.09.008⟩
Annales d'Endocrinologie, Elsevier Masson, 2019, 80 (2), pp.89-95. ⟨10.1016/j.ando.2018.09.008⟩

Objectives The tissue renin-angiotensin system (tRAS) plays a key role in the maintenance of cellular homeostasis but is also implicated in atherosclerosis. Thyroid hormone (TH) contributes, via genomic effects, to control of tRAS gene expression in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9618566bc58d3e59447f7290109d081b
https://hal.science/hal-02360453

Therapeutic Role of Resveratrol and Quercetin on Aortic Fibroblasts of Psammomys obesus After Oxidative Stress by Hydrogen Peroxide

Autor: Leila Smail, Saliha Boumaza, Samia Neggazi, Souhila Aouichat Bouguerra, Ghoti Kacimi, Hamid Sahraoui, Yasmina Benazzoug, Sihem Berdja, Aicha Belkebir

Publikováno v: American journal of therapeutics. 25(3)

In our study, we propose to analyze the effects of resveratrol (RES) and quercetin (QRC) on proliferation markers, oxidative stress, apoptosis, and inflammation of aortic fibroblasts of Psammomys obesus after induced oxidative stress by hydrogen pero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d7d21de7a4166aa26b998154223954d
https://pubmed.ncbi.nlm.nih.gov/26766292