Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Sami Loimas"'
Publikováno v:
BioTechniques, Vol 24, Iss 4, Pp 614-618 (1998)
Green fluorescent protein (GFP) and herpes simplex virus type-1 thymidine kinase (TK) are commonly used markers in gene transfer studies. The latter gene has also proven to be an effective tool in cancer “suicide” gene therapy. To facilitate rapi
Externí odkaz:
https://doaj.org/article/444831ecc5a34f08b1826ee0612a4599
Improvement in Adenoviral Gene Transfer Efficiency after Preincubation at +37°C in Vitro and in Vivo
Autor:
Maija Kossila, Päivi Turunen, Sami Loimas, Jarmo Wahlfors, Seppo Ylä-Herttuala, Pauliina Lehtolainen, Mikko O. Laukkanen, Suvi Jauhiainen, Maiju Jääskeläinen
Publikováno v:
Molecular Therapy. 5(1):87-93
Adenovirus is a widely used vector in gene transfer experiments because it produces high transduction efficiency in vitro and in vivo by means of the coxsackie-adenovirus receptor (CAR) and major histocompatibility complex (MHC) class I alpha-2 domai
Autor:
Heleena Hurskainen, Paula Puranen, Marita Turunen, Maija Kossila, Anu-Maaria Sandmair, Ritva Vanninen, Sami Loimas, Seppo Ylä-Herttuala, Pauliina Lehtolainen, Kristiina Tyynelä, M. Puranen, Leo Paljärvi, Risto Johansson, Arto Immonen, Matti Vapalahti
Publikováno v:
Human Gene Therapy. 11:2197-2205
Herpes simplex virus thymidine kinase (HSV tk) gene therapy combined with ganciclovir (GCV) medication is a potential new method for the treatment of malignant glioma. We have used both retrovirus-packaging cells (PA317/tk) and adenoviruses (Adv/tk)
Publikováno v:
British Journal of Cancer
Pancreatic cancer is one of the most frustrating problems in gastroenterological surgery, since there is little we can do to improve the survival of patients with current treatment strategies. If one is to elucidate factors related to carcinogenesis,
Publikováno v:
The Journal of Gene Medicine. 2:361-367
Background Despite of recent improvements in the treatment of many malignant diseases, pancreatic ductal adenocarcinoma is still a disease with an extremely poor prognosis with current modes of treatment. Gene therapy has been suggested as a novel ap
Autor:
Sami Loimas, Kimmo Mäkinen, Veli-Matti Kosma, Olive S. Pettengill, Esko Alhava, Jarmo Wahlfors, Risto T. Johansson, Daniel S. Longnecker
Publikováno v:
Pancreas. 16:160-164
The purpose of this study was to describe the inoculation technique and patterns of growth as well as to characterize typical histological features of Lewis rat subcutaneous and intrapancreatic tumors, induced by inoculation of cultured pancreatic ca
Publikováno v:
Anticancer research. 27(1A)
Previous studies have shown that, cultured rat pancreatic carcinoma cells, derived from azaserine-induced acinar tumours, yield tumours with a ductal phenotype.In order to find out the molecular characteristics of this tumour model, tumour suppressor
Autor:
Tanja Hakkarainen, Tiina Wahlfors, Outi Meriläinen, Sami Loimas, Akseli Hemminki, Jarmo Wahlfors
Publikováno v:
The journal of gene medicine. 7(7)
VP22 is a herpes simplex virus type 1 (HSV-1) tegument protein that has been suggested to spread from cell to cell, alone or as a part of fusion proteins. Creating controversy, some reports indicate that VP22 cannot facilitate significant intercellul
Autor:
Tanja Hakkarainen, Jyrki Parkkinen, Anni Tenhunen, Jarmo Wahlfors, Pekka Timonen, Sami Loimas, Tiina Pasanen
Publikováno v:
International journal of molecular medicine. 12(4)
The fusion gene of herpes simplex virus thymidine kinase and green fluorescent protein (TK-GFP) was shown to be a versatile tool for examining the features of thymidine kinase/ganciclovir gene therapy in vitro. In this study, we used viral vectors ca
Publikováno v:
Cancer gene therapy. 8(2)
To evaluate human prostate carcinoma cells as targets for herpes simplex virus thymidine kinase (HSV-TK)–mediated gene therapy, we tested the utility of different viral vectors on three human cell lines DU-145, LNCaP, and PC-3. Our viral vectors we