Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Sami Ikonen"'
Publikováno v:
Neuroscience. 116:511-517
Transgenic mice carrying human APPswe and PS1-A264E transgenes (A/P mice) have elevated levels of the highly fibrillogenic amyloid Abeta(1-42) (Abeta) and develop amyloid plaques around the age of 9 months. Our aim was to find whether the gradual acc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313303671f5fc435d7fc35158fc7d36b
https://doi.org/10.1016/s0306-4522(02)00714-5
https://doi.org/10.1016/s0306-4522(02)00714-5
Publikováno v:
Experimental Neurology. 177:565-574
The deposition of amyloid beta peptides (Abeta) and cholinergic dysfunction are two characteristic features of Alzheimer's disease. Several studies have suggested that a compromised cholinergic transmission can increase the amount of amyloid precurso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7ae64949b4a59f5fbf1f74ea21f756c
https://doi.org/10.1006/exnr.2002.8015
https://doi.org/10.1006/exnr.2002.8015
Publikováno v:
Brain Research. 943:181-190
Transgenic mice expressing human APPswe and PS1-A264E mutations mimic certain neuropathological features of Alzheimer's disease (AD). These mice have elevated levels of the highly fibrillogenic amyloid beta1-42 peptide (Abeta42) and develop amyloid p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e5e480b9d4468b6f296bd1ed6765ad0
https://doi.org/10.1016/s0006-8993(02)02617-3
https://doi.org/10.1016/s0006-8993(02)02617-3
Publikováno v:
Experimental Neurology. 173:196-204
Recent studies in cell cultures have shown that modulating the cholinergic activity can influence the processing and metabolism of amyloid precursor protein (APP). To investigate whether acetylcholinesterase inhibitors (ChEIs) could decrease producti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5ec633f8d67dd01b871aa1fda7c196a
https://doi.org/10.1006/exnr.2001.7819
https://doi.org/10.1006/exnr.2001.7819
Autor:
Sami Ikonen, Alcino J. Silva, Karl Peter Giese, Minetta Elgersma, Ofelia M. Carvalho, Esther S. Choi, Ype Elgersma, Fedorov Nikolai
Publikováno v:
Neuron, 36(3), 493-505. Cell Press
To investigate the function of the alpha calcium-calmodulin-dependent kinase II (alphaCaMKII) inhibitory autophosphorylation at threonines 305 and/or 306, we generated knockin mice that express alphaCaMKII that cannot undergo inhibitory phosphorylati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d350e77d095bfbae9ed560dd042a441b
https://doi.org/10.1016/s0896-6273(02)01007-3
https://doi.org/10.1016/s0896-6273(02)01007-3
Autor:
Sami Ikonen, Paavo J. Riekkinen
Publikováno v:
European Journal of Pharmacology. 382:151-156
We investigated the effects of acute i.p. injections of the Ca(2+)-dependent K(+) channel blocker, apamin, on water maze spatial navigation and radial arm maze performance in mice with partial hippocampal-lesions. In the radial arm maze, apamin 0.06
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fdce18692728a47a20c594822b377b1
https://doi.org/10.1016/s0014-2999(99)00616-0
https://doi.org/10.1016/s0014-2999(99)00616-0
Publikováno v:
Early Human Development. 56:39-47
Plasma vitamin A concentrations were measured in cord blood samples from 56 infants of gestational ages < 33 weeks. Outcome was followed prospectively. Mothers' dietary habits and use of multivitamins during pregnancy were evaluated by means of a que
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c76b732fa9ea410b458ceeb55823d7
https://doi.org/10.1016/s0378-3782(99)00032-8
https://doi.org/10.1016/s0378-3782(99)00032-8
Publikováno v:
NeuroReport. 9:3647-3651
The present study examined the efficacy of single and combined treatments with an anticholinesterase, tetrahydroaminoacridine, nicotine and a glycine-B site partial agonist, D-cycloserine, in alleviating the water maze reversal learning defect induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca7d30214082526e7e66e120946e523
https://doi.org/10.1097/00001756-199811160-00016
https://doi.org/10.1097/00001756-199811160-00016
Publikováno v:
European Journal of Pharmacology. 347:13-21
We investigated the effects of acute i.p. injections of the Ca2+-dependent K+ channel blocker, apamin, on water maze spatial navigation, Y-maze and passive avoidance behavior in intact and medial septal-lesioned mice. Apamin 0.02, 0.06 or 0.2 mg/kg (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf514a6a09bc9227714cda5b7331277
https://doi.org/10.1016/s0014-2999(98)00075-2
https://doi.org/10.1016/s0014-2999(98)00075-2
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(29)
Aging is associated with spatial memory impairments and with deficient encoding of information by the hippocampus. In young adult rats, recent studies on the firing properties of hippocampal neurons have emphasized the importance of the CA3 subregion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd32898c58767ca1015ac2cf7bad617
https://pubmed.ncbi.nlm.nih.gov/16033897
https://pubmed.ncbi.nlm.nih.gov/16033897