Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sami Gabbouj"'
Autor:
Teemu Natunen, Henna Martiskainen, Mikael Marttinen, Sami Gabbouj, Hennariikka Koivisto, Susanna Kemppainen, Satu Kaipainen, Mari Takalo, Helena Svobodová, Luukas Leppänen, Benjam Kemiläinen, Simo Ryhänen, Teemu Kuulasmaa, Eija Rahunen, Sisko Juutinen, Petra Mäkinen, Pasi Miettinen, Tuomas Rauramaa, Jussi Pihlajamäki, Annakaisa Haapasalo, Ville Leinonen, Heikki Tanila, Mikko Hiltunen
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-30 (2020)
Abstract Background Alzheimer’s disease (AD) is the most common neurodegenerative disease and type 2 diabetes (T2D) plays an important role in conferring the risk for AD. Although AD and T2D share common features, the common molecular mechanisms un
Externí odkaz:
https://doaj.org/article/0a5157aefa5741f49d346794317e84b4
Autor:
Szabolcs Felszeghy, Sanna Pasonen-Seppänen, Ali Koskela, Petteri Nieminen, Kai Härkönen, Kaisa M. A. Paldanius, Sami Gabbouj, Kirsi Ketola, Mikko Hiltunen, Mikael Lundin, Tommi Haapaniemi, Erkko Sointu, Eric B. Bauman, Gregory E. Gilbert, David Morton, Anitta Mahonen
Publikováno v:
BMC Medical Education, Vol 19, Iss 1, Pp 1-11 (2019)
Abstract Background Human morphology is a critical component of dental and medical graduate training. Innovations in basic science teaching methods are needed to keep up with an ever-changing landscape of technology. The purpose of this study was to
Externí odkaz:
https://doaj.org/article/475739afb9c145d1977ca2e55bc740f2
Autor:
Sami Gabbouj, Simo Ryhänen, Mikael Marttinen, Rebekka Wittrahm, Mari Takalo, Susanna Kemppainen, Henna Martiskainen, Heikki Tanila, Annakaisa Haapasalo, Mikko Hiltunen, Teemu Natunen
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Alzheimer’s disease (AD) and type 2 diabetes (T2D) are both diseases with increasing prevalence in aging populations. T2D, characterized by insulin resistance and defective insulin signaling, is a common co-morbidity and a risk factor for AD, incre
Externí odkaz:
https://doaj.org/article/15215aa0ee3d4acfb1f0bd56cde7b958
Autor:
Mikael Marttinen, Mari Takalo, Teemu Natunen, Rebekka Wittrahm, Sami Gabbouj, Susanna Kemppainen, Ville Leinonen, Heikki Tanila, Annakaisa Haapasalo, Mikko Hiltunen
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Alzheimer’s disease (AD) is the most common neurodegenerative disorder, which is clinically associated with a global cognitive decline and progressive loss of memory and reasoning. According to the prevailing amyloid cascade hypothesis of AD, incre
Externí odkaz:
https://doaj.org/article/6f679eb2278c49e0b4c93bf596c990eb
Autor:
Teemu Natunen, Mari Takalo, Susanna Kemppainen, Stina Leskelä, Mikael Marttinen, Kaisa M.A. Kurkinen, Juha-Pekka Pursiheimo, Timo Sarajärvi, Jayashree Viswanathan, Sami Gabbouj, Eino Solje, Eveliina Tahvanainen, Tiina Pirttimäki, Mitja Kurki, Jussi Paananen, Tuomas Rauramaa, Pasi Miettinen, Petra Mäkinen, Ville Leinonen, Hilkka Soininen, Kari Airenne, Rudolph E. Tanzi, Heikki Tanila, Annakaisa Haapasalo, Mikko Hiltunen
Publikováno v:
Neurobiology of Disease, Vol 85, Iss , Pp 187-205 (2016)
Accumulation of β-amyloid (Aβ) and phosphorylated tau in the brain are central events underlying Alzheimer's disease (AD) pathogenesis. Aβ is generated from amyloid precursor protein (APP) by β-site APP-cleaving enzyme 1 (BACE1) and γ-secretase-
Externí odkaz:
https://doaj.org/article/fec99dbad77e483d989eaa39ef52f9e5
Autor:
Luukas Leppänen, Petra Mäkinen, Helena Svobodova, Simo Ryhänen, Teemu Natunen, Jussi Pihlajamäki, Mikael Marttinen, Heikki Tanila, Sisko Juutinen, Teemu Kuulasmaa, Sami Gabbouj, Mikko Hiltunen, Annakaisa Haapasalo, Henna Martiskainen, Mari Takalo, Benjam Kemiläinen, Susanna Kemppainen, Ville Leinonen, Hennariikka Koivisto, Satu Kaipainen, Tuomas Rauramaa, Eija Rahunen, Pasi Miettinen
Publikováno v:
Molecular Neurodegeneration
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-30 (2020)
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-30 (2020)
BackgroundAlzheimer’s disease (AD) is the most common neurodegenerative disease and type 2 diabetes (T2D) plays an important role in conferring the risk for AD. Although AD and T2D share common features, the common molecular mechanisms underlying t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85fd870da1421e6576206fc671ff7de7
https://pubmed.ncbi.nlm.nih.gov/33168021
https://pubmed.ncbi.nlm.nih.gov/33168021
Autor:
Susanna Kemppainen, Rahunen E, Petri I. Mäkinen, Teemu Natunen, Pasi Miettinen, Hennariikka Koivisto, Heikki Tanila, M. Hiltunen, Simo Ryhänen, Luukas Leppänen, Annakaisa Haapasalo, Leinonen, Tuomas Rauramaa, Sami Gabbouj, Mikael Marttinen, Kemiläinen B, Henna Martiskainen, Helena Svobodova, Satu Kaipainen, Mari Takalo, Teemu Kuulasmaa, Sisko Juutinen, Jussi Pihlajamäki
Type 2 diabetes (T2D) increases the risk of Alzheimer’s disease (AD). Even though these two diseases share common molecular pathways, the mechanisms remain elusive. To shed light into these mechanisms, mice with different AD- and/or tauopathy-linke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12fcdf9c4d8629ecd2998f409325eee5
Autor:
Mari Takalo, Juha-Pekka Pursiheimo, Jussi Paananen, Tiina Pirttimäki, Eino Solje, Heikki Tanila, Tuomas Rauramaa, Pasi Miettinen, Sami Gabbouj, Rudolph E. Tanzi, Ville Leinonen, Stina Leskelä, Timo Sarajärvi, Teemu Natunen, Mitja I. Kurki, Mikko Hiltunen, Jayashree Viswanathan, Susanna Kemppainen, Annakaisa Haapasalo, Mikael Marttinen, Eveliina Tahvanainen, Kaisa M.A. Kurkinen, Kari J. Airenne, Hilkka Soininen, Petra Mäkinen
Publikováno v:
Neurobiology of Disease, Vol 85, Iss, Pp 187-205 (2016)
Accumulation of β-amyloid (Aβ) and phosphorylated tau in the brain are central events underlying Alzheimer's disease (AD) pathogenesis. Aβ is generated from amyloid precursor protein (APP) by β-site APP-cleaving enzyme 1 (BACE1) and γ-secretase-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c72e0865d092c411e96e238f16d6e1
https://doi.org/10.1016/j.nbd.2015.11.005
https://doi.org/10.1016/j.nbd.2015.11.005
SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1
Autor:
Petra Mäkinen, Heikki Tanila, Tuomas Rauramaa, Hilkka Soininen, Mikko Hiltunen, Ville Leinonen, Sami Gabbouj, Kaisa M.A. Kurkinen, Fanni Haapalinna, Timo Sarajärvi, Laura J. Turner, Teemu Natunen, Mitja I. Kurki, Annakaisa Haapasalo, Jussi Paananen, Mikael Marttinen, Anne M. Koivisto, Fiona R. Lucas
Publikováno v:
Journal of cell science. 129(11)
Dysfunction and loss of synapses are early pathogenic events in Alzheimer's disease. A central step in the generation of toxic amyloid-β (Aβ) peptides is the cleavage of amyloid precursor protein (APP) by β-site APP-cleaving enzyme (BACE1). Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88edb67fea49ee010e9e3b03272e9f9a
https://pubmed.ncbi.nlm.nih.gov/27084579
https://pubmed.ncbi.nlm.nih.gov/27084579
Autor:
Pekka Poutiainen, Kimmo Jokivarsi, Heikki Tanila, Orfeu Flores, Mari Takalo, Adrián Posado-Fernández, Susanna Kemppainen, Hennariikka Koivisto, Sami Gabbouj, Simo Ryhänen, Mikko Hiltunen, Rebekka Wittrahm, Teemu Natunen, Kaisa M. A. Paldanius, Annakaisa Haapasalo, Petra Mäkinen, Reyhaneh Naderi, Gonçalo Doria, Mikael Marttinen
Publikováno v:
Neurobiology of Aging
Type 2 diabetes mellitus (T2DM) increases the risk for Alzheimer's disease (AD). Human AD brains show reduced glucose metabolism as measured by [18F]fluoro-2-deoxy-2-D-glucose positron emission tomography (FDG-PET). Here, we used 14-month-old wild-ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db77899997e4729df8a18e1275fb74cd