Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sami Caner"'
Autor:
Christina R. Tysoe, Sami Caner, Matthew B. Calvert, Anna Win-Mason, Gary D. Brayer, Stephen G. Withers
Publikováno v:
Chemical Science
Simplified analogues of montbretin A bind similarly to human alpha amylase and with nanomolar affinity.
Simplified analogues of the potent human amylase inhibitor montbretin A were synthesised and shown to bind tightly, KI = 60 and 70 nM, with i
Simplified analogues of the potent human amylase inhibitor montbretin A were synthesised and shown to bind tightly, KI = 60 and 70 nM, with i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18982f3cc8fb86724cbae779804f55d2
https://pubmed.ncbi.nlm.nih.gov/32206255
https://pubmed.ncbi.nlm.nih.gov/32206255
Publikováno v:
Biochemistry. 55:6000-6009
Starch provides the major source of caloric intake in many diets. Cleavage of starch into malto-oligosaccharides in the gut is catalyzed by pancreatic α-amylase. These oligosaccharides are then further cleaved by gut wall α-glucosidases to release
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4493d7815e58f57275eb511267b2b46
https://doi.org/10.1021/acs.biochem.6b00992
https://doi.org/10.1021/acs.biochem.6b00992
Autor:
David E. Williams, Jacqueline Wicki, Gary D. Brayer, Coleman John, Leslie K. Williams, Stephen G. Withers, Nham T. Nguyen, Raymond J. Andersen, Violet G. Yuen, Xiaohua Zhang, Sami Caner, John H. McNeill, Christina Tysoe
Publikováno v:
Nature Chemical Biology. 11:691-696
The complex plant flavonol glycoside montbretin A is a potent (Ki = 8 nM) and specific inhibitor of human pancreatic α-amylase with potential as a therapeutic for diabetes and obesity. Controlled degradation studies on montbretin A, coupled with inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae166e64668f81caf292fcc5b366489b
https://doi.org/10.1038/nchembio.1865
https://doi.org/10.1038/nchembio.1865
Publikováno v:
Nature chemical biology
Evolutionary advances are often fueled by unanticipated innovation. Directed evolution of a computationally designed enzyme suggests that dramatic molecular changes can also drive the optimization of primitive protein active sites. The specific activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f685642985da5280826f640d67df1cec
Autor:
Xiaohua Zhang, Sami Caner, Gary D. Brayer, Jianbing Jiang, Stephen G. Withers, Nham T. Nguyen, Hermen S. Overkleeft, Hong-Ming Chen
Publikováno v:
FEBS letters. 590(8)
As part of a search for selective, mechanism-based covalent inhibitors of human pancreatic α-amylase we describe the chemoenzymatic synthesis of the disaccharide analog α-glucosyl epi-cyclophellitol, demonstrate its stoichiometric reaction with hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab0599867e01af9c0547afe2790ef909
https://pubmed.ncbi.nlm.nih.gov/27000970
https://pubmed.ncbi.nlm.nih.gov/27000970
Autor:
Stephen G. Withers, Gary D. Brayer, Nham T. Nguyen, Sami Caner, Adeleke Aguda, Yuan T. Pan, Ran Zhang
Trehalose synthase (TreS) catalyzes the reversible conversion of maltose into trehalose in mycobacteria as one of three biosynthetic pathways to this nonreducing disaccharide. Given the importance of trehalose to survival of mycobacteria, there has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::738037f96ada1dccca446f89ee54f925
https://europepmc.org/articles/PMC3724413/
https://europepmc.org/articles/PMC3724413/
Autor:
Yuan Pan, Ran Zhang, Adeleke Aguda, Stephen G. Withers, Sami Caner, Nham T. Nguyen, Gary D. Brayer
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 70:C441-C441
Trehalose synthase (TreS) catalyzes the reversible conversion of maltose to trehalose in mycobacteria as one of three biosynthetic pathways to this non-reducing disaccharide. Given the importance of trehalose to survival of mycobacteria there has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43ad5848cf86bfaa30828c9f4cdceb76
https://doi.org/10.1107/s2053273314095588
https://doi.org/10.1107/s2053273314095588
Autor:
Adeleke Aguda, Sami Caner, Nham T. Nguyen, Gary D. Brayer, Amina Zoubeidi, Martin E. Gleave, Barbara Lelj-Garolla, Susan C. Moore
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 70:C804-C804
Human heat shock protein 27 (Hsp27) is an oligomeric and cell survival protein that has been associated with several cancers including prostrate and breast cancer. It's a known anti-apoptotic protein that functions as a molecular chaperone for severa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c997da440cc193455da8ba9bc58357ec
https://doi.org/10.1107/s2053273314091955
https://doi.org/10.1107/s2053273314091955