Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Sami Alakurtti"'
Autor:
Michael Kirstgen, Kira Alessandra Alicia Theresa Lowjaga, Simon Franz Müller, Nora Goldmann, Felix Lehmann, Sami Alakurtti, Jari Yli-Kauhaluoma, Dieter Glebe, Joachim Geyer
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Abstract Current treatment options against hepatitis B and D virus (HBV/HDV) infections have only limited curative effects. Identification of Na+/taurocholate co-transporting polypeptide (NTCP) as the high-affinity hepatic receptor for both viruses i
Externí odkaz:
https://doaj.org/article/b5edf866c0b64b18948a6735dc0b00e5
Identification of Novel HBV/HDV Entry Inhibitors by Pharmacophore- and QSAR-Guided Virtual Screening
Autor:
Michael Kirstgen, Simon Franz Müller, Kira Alessandra Alicia Theresa Lowjaga, Nora Goldmann, Felix Lehmann, Sami Alakurtti, Jari Yli-Kauhaluoma, Karl-Heinz Baringhaus, Reimar Krieg, Dieter Glebe, Joachim Geyer
Publikováno v:
Viruses, Vol 13, Iss 8, p 1489 (2021)
The hepatic bile acid transporter Na+/taurocholate co-transporting polypeptide (NTCP) was identified in 2012 as the high-affinity hepatic receptor for the hepatitis B and D viruses (HBV/HDV). Since then, this carrier has emerged as promising drug tar
Externí odkaz:
https://doaj.org/article/cb79f7a43a3f4f3d805541d8ec8351e8
Autor:
Wilmer Alcazar, Sami Alakurtti, Maritza Padrón-Nieves, Maija Liisa Tuononen, Noris Rodríguez, Jari Yli-Kauhaluoma, Alicia Ponte-Sucre
Publikováno v:
Microorganisms, Vol 9, Iss 2, p 320 (2021)
Herein, we evaluated in vitro the anti-leishmanial activity of betulin derivatives in Venezuelan isolates of Leishmania amazonensis, isolated from patients with therapeutic failure. Methods: We analyzed promastigote in vitro susceptibility as well as
Externí odkaz:
https://doaj.org/article/78a75dd76c494dcb9c8704b63f0180a0
Autor:
Ville Härmä, Raisa Haavikko, Johannes Virtanen, Ilmari Ahonen, Hannu-Pekka Schukov, Sami Alakurtti, Enkhee Purev, Heiko Rischer, Jari Yli-Kauhaluoma, Vânia M Moreira, Matthias Nees, Kirsi-Marja Oksman-Caldentey
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126111 (2015)
The anti-invasive and anti-proliferative effects of betulins and abietane derivatives was systematically tested using an organotypic model system of advanced, castration-resistant prostate cancers. A preliminary screen of the initial set of 93 compou
Externí odkaz:
https://doaj.org/article/0c77af03b5934c578a8a3ef2eb49c8cf
Autor:
Teija Parkkari, Raisa Haavikko, Tuomo Laitinen, Dina Navia-Paldanius, Roosa Rytilahti, Miia Vaara, Marko Lehtonen, Sami Alakurtti, Jari Yli-Kauhaluoma, Tapio Nevalainen, Juha R Savinainen, Jarmo T Laitinen
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98286 (2014)
Backgroundα/β-Hydrolase domain containing (ABHD)12 is a recently discovered serine hydrolase that acts in vivo as a lysophospholipase for lysophosphatidylserine. Dysfunctional ABHD12 has been linked to the rare neurodegenerative disorder called PHA
Externí odkaz:
https://doaj.org/article/f7600b4b8e944d0bb49648130289d3b2
Autor:
Shafiul Haque, Dorota A Nawrot, Sami Alakurtti, Leo Ghemtio, Jari Yli-Kauhaluoma, Päivi Tammela
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102696 (2014)
Betulin (lup-20(29)-ene-3β, 28-diol) is a naturally occurring triterpene, which is found in substantial amounts from the outer bark of birch trees. A library of 51 structurally diverse semisynthetic betulin derivatives was screened against five bact
Externí odkaz:
https://doaj.org/article/fc5817bd3a1444539d9eefe420811408
Autor:
Mari Hämäläinen, Vânia M. Moreira, Raisa Haavikko, Jari Yli-Kauhaluoma, Ilari Mäki-Opas, Eeva Moilanen, Lauri J. Moilanen, Sami Alakurtti, Katsuhiko Muraki, Tiina Ahonen
Publikováno v:
Mäki-Opas, I, Hämäläinen, M, Moilanen, L J, Haavikko, R, Ahonen, T J, Alakurtti, S, Moreira, V M, Muraki, K, Yli-Kauhaluoma, J & Moilanen, E 2019, ' Pyrazine-Fused Triterpenoids Block the TRPA1 Ion Channel in Vitro and Inhibit TRPA1-Mediated Acute Inflammation in Vivo ', ACS Chemical Neuroscience, vol. 10, no. 6, pp. 2848-2857 . https://doi.org/10.1021/acschemneuro.9b00083
TRPA1 is a nonselective cation channel, most famously expressed in nonmyelinated nociceptors. In addition to being an important chemical and mechanical pain sensor, TRPA1 has more recently appeared to have a role also in inflammation. Triterpenoids a
Autor:
Sami Alakurtti, Mari Hämäläinen, Eeva Moilainen, Raisa Haavikko, Lauri J Moilainen, Katsuhiko Muraki, Vania Moreira, Jari Yli-Kauhaluoma, Tiina Ahonen, Ilari Mäki-Opas
Publikováno v:
Scandinavian Journal of Rheumatology. 46:419-424
Autor:
Urve Paaver, Minni Pirttimaa, Janne Hulkko, Jaan Aruväli, Karin Kogermann, Sami Alakurtti, Heimo Kanerva, Jouko Yliruusi, Jyrki Heinämäki, H. Pauliina Pitkänen
Publikováno v:
Heinämäki, J, Pirttimaa, M M, Alakurtti, S, Pitkänen, P H, Kanerva, H, Hulkko, J, Paaver, U, Aruväli, J, Yliruusi, J & Kogermann, K 2017, ' Suberin fatty acids from outer birch bark : Isolation and physical material characterization ', Journal of Natural Products, vol. 80, no. 4, pp. 916-924 . https://doi.org/10.1021/acs.jnatprod.6b00771
The isolation and physical material properties of suberin fatty acids (SFAs) were investigated with special reference to their potential applications as novel pharmaceutical excipients. SFAs were isolated from outer birch bark (OBB) with a new extrac
Autor:
Kirsi-Marja Oksman-Caldentey, Minni Pirttimaa, Charles L. Jaffe, Vânia M. Moreira, Dmitry Kopelyanskiy, Sami Alakurtti, Marcel Kaiser, Jari Yli-Kauhaluoma, Reto Brun, Abedelmajeed Nasereddin
Publikováno v:
Pirttimaa, M, Nasereddin, A, Kopelyanskiy, D, Kaiser, M, Yli-Kauhaluoma, J, Oksman-Caldentey, K-M, Brun, R, Jaffe, C L, Moreira, V M & Alakurtti, S 2016, ' Abietane-Type Diterpenoid Amides with Highly Potent and Selective Activity against Leishmania donovani and Trypanosoma cruzi ', Journal of Natural Products, vol. 79, no. 2, pp. 362-368 . https://doi.org/10.1021/acs.jnatprod.5b00990
Dehydroabietylamine (1) was used as a starting material to synthesize a small library of dehydroabietyl amides by simple and facile methods, and their activities against two disease-causing trypanosomatids, namely, Leishmania donovani and Trypanosoma