Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Sames, Sicsic"'
Autor:
Frank Lezoualc'h, Céline Rivière, Jean-Louis Soulier, Jean-Pierre Monti, Olivier Russo, Sames Sicsic, Marthe Cachard-Chastel, Isabelle Berque-Bestel, Tristan Richard, Mireille Giner, Magali Berthouze
Publikováno v:
Journal of Medicinal Chemistry. 52:2214-2225
Serotonin 5-HT(4) receptor (5-HT(4)R) agonists are of particular interest for the treatment of Alzheimer's disease because of their ability to ameliorate cognitive deficits and to modulate production of amyloid beta-protein (Abeta). However, despite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f92df50bc84ffa6d24be4d7e4425ed
https://doi.org/10.1021/jm801327q
https://doi.org/10.1021/jm801327q
Autor:
Jean-François Peyrat, Sames Sicsic, Nathanael Olivi, Olivier Russo, Isabelle Berque-Bestel, Mouad Alami, Abdallah Hamze, Jean-Daniel Brion, Samir Messaoudi
Publikováno v:
Tetrahedron. 63:10671-10683
An efficient palladium–copper-catalyzed three-component assembling of propargyl halides, aryl or heteroaryl halides, and secondary amines is described. A wide variety of tertiary propargylic amines were synthesized in good to excellent yields from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14c97ea2c6ec2ad37adc48d4ec23be78
https://doi.org/10.1016/j.tet.2007.07.096
https://doi.org/10.1016/j.tet.2007.07.096
Publikováno v:
Journal of Molecular Structure: THEOCHEM. 817:19-26
The serotonin, h5-HT4 receptor is a G protein-coupled receptor (GPCR) known to be involved in a variety of pathological disorders such as irritable bowel syndrome, cardiac atrial arrhythmia and memory deficits. Recent studies have also underlined its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b043794a1bc037180ef2eab5ae645d65
https://doi.org/10.1016/j.theochem.2007.04.012
https://doi.org/10.1016/j.theochem.2007.04.012
Autor:
Frank Lezoualc'h, Michel Langlois, Claudine Deloménie, F. Van Leuven, Herman Devijver, S. Croes, Sames Sicsic, Alain M. Gardier, Ilse Dewachter, M. Cachard-Chastel
Publikováno v:
British Journal of Pharmacology. 150:883-892
Background and purpose: A strategy to treat Alzheimer’s disease (AD) is to increase the soluble form of amyloid precursor protein (sAPPa), a promnesic protein, in the brain. Because strong evidence supports beneficial effects of 5-hydroxytryptamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d696d8962e982cf9d5c40118ba82c2fd
https://doi.org/10.1038/sj.bjp.0707178
https://doi.org/10.1038/sj.bjp.0707178
Publikováno v:
European Journal of Biochemistry. 127:513-517
Hydrosoluble Polymers of NAD+ and ADP. Coenzymatic Properties as a Function of their Size Hydrosoluble polymers of NAD+ and ADP were synthesized according to a described method with some modifications. The cofactor was bound to the matrix by a spacer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad2305f3e3e7483c411656e37bba2727
https://doi.org/10.1111/j.1432-1033.1982.tb06901.x
https://doi.org/10.1111/j.1432-1033.1982.tb06901.x
Autor:
Lucie Rivail, Bernard Maigret, Mireille Giner, Monique Gastineau, Isabelle Berque-Bestel, Frank Lezoualc'h, Sames Sicsic, Magali Berthouze, Rodolphe Fischmeister, Jean-Louis Soulier
Publikováno v:
British Journal of Pharmacology. 143:361-370
A body of evidences suggests that a hydrophobic pocket of the human 5-HT4 receptor contributes to the high affinity of some bulky 5-HT4 ligands. A thorough study of this pocket was performed using mutagenesis and molecular modeling. Ligand binding or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9db6caed5b198b1ab0daf29235e59f0a
https://doi.org/10.1038/sj.bjp.0705950
https://doi.org/10.1038/sj.bjp.0705950
Publikováno v:
Tetrahedron Letters. 45:7069-7072
A rapid and flexible synthetic approach to {[bis( tert -butoxycarbonyl)amino]propyl}piperidines 5 and related compounds is described. The key step is a three-component coupling process of 2-, 3- or 4-bromopyridine, propargyl bromide and potassium di-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bfe07f40d9226ffc981d85c584bbe18
https://doi.org/10.1016/j.tetlet.2004.07.118
https://doi.org/10.1016/j.tetlet.2004.07.118
Autor:
Sames Sicsic, Zohra Benatallah, Ginette Deby-Dupont, François Durant, Ange Mouithys-Mickalad, René Lapouyade, Marie Ledecq, Florence Lebon, Nicole Boggetto, Michèle Reboud-Ravaux, Olivier Kahn
Publikováno v:
Biochemical Pharmacology. 63:1863-1873
The use of metal-organic complexes is a potentially fruitful approach for the development of novel enzyme inhibitors. They hold the attractive promise of forming stronger attachments with the target by combining the co-ordination ability of metals wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cde76f86a7d8eda9caccf8672d0a867
https://doi.org/10.1016/s0006-2952(02)00918-8
https://doi.org/10.1016/s0006-2952(02)00918-8
Autor:
Jeanne Mialet, Michel Langlois, Sames Sicsic, Isabelle Berque-Bestel, Frank Lezoualc'h, Rodolphe Fischmeister
Publikováno v:
British Journal of Pharmacology. 131:827-835
The recently identified C-terminal splice variant of the human 5-HT(4) receptor, the h5-HT(4(d)) receptor, was stably expressed in a CHO cell line at 493+/-25 fmol mg(-1) protein. We analysed its pharmacological properties by measuring binding affini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca4b2f00fe6bf34cb64a81615c5e395d
https://doi.org/10.1038/sj.bjp.0703641
https://doi.org/10.1038/sj.bjp.0703641
Autor:
Ivan Zahradnik, Mireille Giner, Michel Langlois, Sames Sicsic, Isabelle Berque-Bestel, Jeanne Mialet, Jean-Louis Soulier, Rodolphe Fischmeister, Frank Lezoualc'h, Sophie Curtet, Patrick Donzeau-Gouge
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2000, 43 (20), pp.3761-3769. ⟨10.1021/jm0009538⟩
Journal of Medicinal Chemistry, 2000, 43 (20), pp.3761-3769. ⟨10.1021/jm0009538⟩
International audience; New derivatives of arylpiperazine 9 were designed from ML 10302, a potent 5-HT 4 receptor agonist in the gastrointestinal system. Compounds were synthesized by condensation of a number of available arylpiperazines or heteroary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e623e3fa2d26bb562759e326bd87db
https://doi.org/10.1021/jm0009538
https://doi.org/10.1021/jm0009538