Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Samer Haidar"'
Autor:
Priscila López-Rojas, Samer Haidar, Franziska M. Jürgens, Dagmar Aichele, Ángel Amesty, Ana Estévez-Braun, Joachim Jose
Publikováno v:
Results in Chemistry, Vol 6, Iss , Pp 100997- (2023)
Human protein kinase CK2 is an important target for the development of anticancer drugs. Many inhibitors were developed in the last few decades, among them emodin, a natural inhibitor with anthracene-9,10-dione backbone. In this work the inhibitory a
Externí odkaz:
https://doaj.org/article/edbe43404e6b4e7a8f8a8da04a8ee2f6
Publikováno v:
Journal of Comparative Effectiveness Research, Vol 12, Iss 7 (2023)
Aim: To compare the length of stay, hospital costs and hospital revenues for Medicare patients with and without a subset of potentially preventable postoperative complications after major noncardiac surgery. Materials & methods: Retrospective data
Externí odkaz:
https://doaj.org/article/13ded52d68094143b04b567f4d7b6b40
Autor:
Samer Haidar, Franziska M. Jürgens, Dagmar Aichele, Annika Jagels, Hans-Ulrich Humpf, Joachim Jose
Publikováno v:
Molecules, Vol 26, Iss 15, p 4453 (2021)
A large number of secondary metabolites have been isolated from the filamentous fungus Stachybotrys chartarum and have been described before. Fourteen of these natural compounds were evaluated in vitro in the present study for their inhibitory activi
Externí odkaz:
https://doaj.org/article/8480c8d81b4f4dd6803f33abe9dda6cd
Autor:
Samer Haidar, Christelle Marminon, Dagmar Aichele, Abdelhamid Nacereddine, Wael Zeinyeh, Abdeslem Bouzina, Malika Berredjem, Laurent Ettouati, Zouhair Bouaziz, Marc Le Borgne, Joachim Jose
Publikováno v:
Molecules, Vol 25, Iss 1, p 97 (2019)
Casein kinase II (CK2) is an intensively studied enzyme, involved in different diseases, cancer in particular. Different scaffolds were used to develop inhibitors of this enzyme. Here, we report on the synthesis and biological evaluation of twenty ph
Externí odkaz:
https://doaj.org/article/cead735122584236b050184220a83eb4
Autor:
Samer Haidar, Dagmar Aichele, Robin Birus, Janine Hielscher, Tuomo Laitinen, Antti Poso, Joachim Jose
Publikováno v:
Molecules, Vol 24, Iss 7, p 1380 (2019)
Protein kinase CK2 is an emerging target for therapeutic intervention in human diseases, particularly in cancer. Inhibitors of this enzyme are currently in clinical trials, indicating the druggability of human CK2. By virtual screening of the ZINC da
Externí odkaz:
https://doaj.org/article/d5abb7f1977c480585b9520c034aa10d
Autor:
Samer Haidar, Zouhair Bouaziz, Christelle Marminon, Tuomo Laitinen, Antti Poso, Marc Le Borgne, Joachim Jose
Publikováno v:
Pharmaceuticals, Vol 10, Iss 1, p 8 (2017)
Protein kinase CK2, initially designated as casein kinase 2, is an ubiquitously expressed serine/threonine kinase. This enzyme, implicated in many cellular processes, is highly expressed and active in many tumor cells. A large number of compounds has
Externí odkaz:
https://doaj.org/article/301b4dbe12284dfb8a4330a98c981b1f
Publikováno v:
Pharmaceuticals, Vol 9, Iss 1, p 1 (2015)
The European Conference on Therapeutic Targets and Medicinal Chemistry is a new two-day meeting on drug discovery that is focused on therapeutic targets and the use of tools to explore all fields of drug discovery and drug design such as molecular mo
Externí odkaz:
https://doaj.org/article/ae2ae815e98641cb964268e6d0ce65bb
Autor:
Ahmed Idbaih, Keith L. Ligon, Jean-Yves Delattre, Patrick Y. Wen, Brian M. Alexander, Marc Sanson, Khê Hoang-Xuan, Karima Mokhtari, Azra H. Ligon, Yannick Marie, Marianne Labussière, David Knoff, Jeremy Guehennec, Camille Levasseur, Samer Haidar, Kristine Pelton, Lauriane Goldwirt, Charlotte Schmitt, Maite Verreault
Purpose: p53 pathway alterations are key molecular events in glioblastoma (GBM). MDM2 inhibitors increase expression and stability of p53 and are presumed to be most efficacious in patients with TP53 wild-type and MDM2-amplified cancers. However, thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf9aba75727d610f0812dc8315ede6a
https://doi.org/10.1158/1078-0432.c.6523347.v1
https://doi.org/10.1158/1078-0432.c.6523347.v1
Autor:
Ahmed Idbaih, Keith L. Ligon, Jean-Yves Delattre, Patrick Y. Wen, Brian M. Alexander, Marc Sanson, Khê Hoang-Xuan, Karima Mokhtari, Azra H. Ligon, Yannick Marie, Marianne Labussière, David Knoff, Jeremy Guehennec, Camille Levasseur, Samer Haidar, Kristine Pelton, Lauriane Goldwirt, Charlotte Schmitt, Maite Verreault
S3: Evolution of MDM2 and TP53 status over time of 5 patients affected by MDM2-amplified GBM.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17de4e663732b253b5fbd943086589b7
https://doi.org/10.1158/1078-0432.22456560
https://doi.org/10.1158/1078-0432.22456560
Autor:
Ahmed Idbaih, Keith L. Ligon, Jean-Yves Delattre, Patrick Y. Wen, Brian M. Alexander, Marc Sanson, Khê Hoang-Xuan, Karima Mokhtari, Azra H. Ligon, Yannick Marie, Marianne Labussière, David Knoff, Jeremy Guehennec, Camille Levasseur, Samer Haidar, Kristine Pelton, Lauriane Goldwirt, Charlotte Schmitt, Maite Verreault
S6: MDM2, MDM4 and p53 protein level in the GBM cell lines of cohort #1 as determined by western blot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b9d46d2aa3bef1d1ca0ff080d9bb00
https://doi.org/10.1158/1078-0432.22456551.v1
https://doi.org/10.1158/1078-0432.22456551.v1