Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Sameh, Eid"'
Autor:
Ebru Ercan, Sameh Eid, Christian Weber, Alexandra Kowalski, Maria Bichmann, Annika Behrendt, Frank Matthes, Sybille Krauss, Peter Reinhardt, Simone Fulle, Dagmar E. Ehrnhoefer
Publikováno v:
Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-19 (2017)
Abstract Background Tau is a microtubule-binding protein, which is subject to various post-translational modifications (PTMs) including phosphorylation, methylation, acetylation, glycosylation, nitration, sumoylation and truncation. Aberrant PTMs suc
Externí odkaz:
https://doaj.org/article/437f516a84194ce1aac4371077d7c061
Autor:
Said Rabbani, Eva-Maria Krammer, Goedele Roos, Adam Zalewski, Roland Preston, Sameh Eid, Pascal Zihlmann, Martine Prévost, Marc F. Lensink, Andrew Thompson, Beat Ernst, Julie Bouckaert
Publikováno v:
IUCrJ, Vol 4, Iss 1, Pp 7-23 (2017)
The most prevalent diseases manifested by Escherichia coli are acute and recurrent bladder infections and chronic inflammatory bowel diseases such as Crohn's disease. E. coli clinical isolates express the FimH adhesin, which consists of a mannose-spe
Externí odkaz:
https://doaj.org/article/d86faef2f2ce48af946c95b24edbfd5b
Carbohydrates play a key role in a variety of physiological and pathological processes and, hence, represent a rich source for the development of novel therapeutic agents. Being able to predict binding mode and binding affinity is an essential, yet l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::364708e43434a0d4a06dad7d5dbc0163
http://doc.rero.ch/record/325194/files/10822_2014_Article_9794.pdf
http://doc.rero.ch/record/325194/files/10822_2014_Article_9794.pdf
Autor:
Ola Farouk Leheta, Hatem K. Amin, Moustafa E. Dawoud, Amr M. El-Araby, Sameh Eid, Tamer Nasr, Samir Bondock
Publikováno v:
Advances in Biological Chemistry. :76-87
Purpose: Aim of this study is to assess the anti-proliferative effect of the thiazole analogue (5-acetyl-4-methyl-2-(3-pyridyl) thiazole) with different human carcinoma cell lines and to postulate its possible mechanism of action using molecular mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dda145c1ea691bf9d9123a4fb029b825
https://doi.org/10.4236/abc.2017.71005
https://doi.org/10.4236/abc.2017.71005
Publikováno v:
Journal of Medicinal Chemistry. 60:474-485
Kinome-wide screening would have the advantage of providing structure-activity relationships against hundreds of targets simultaneously. Here, we report the generation of ligand-based activity prediction models for over 280 kinases by employing Machi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fe1c2a8f8bc90dc62327be1ddd62689
https://doi.org/10.1021/acs.jmedchem.6b01611
https://doi.org/10.1021/acs.jmedchem.6b01611
Publikováno v:
Journal of medicinal chemistry. 61(11)
Elimination of inadvertent binding is crucial for inhibitor design targeting conserved protein classes like kinases. Compounds in clinical trials provide a rich source for initiating drug design efforts by exploiting such secondary binding events. Co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1687177d899d7e97ceb545f468ec8dc
https://pubmed.ncbi.nlm.nih.gov/29746776
https://pubmed.ncbi.nlm.nih.gov/29746776
Publikováno v:
Journal of Chemical Information and Modeling. 56:335-346
The identification and design of selective compounds is important for the reduction of unwanted side effects as well as for the development of tool compounds for target validation studies. This is, in particular, true for therapeutically important pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dbf8cc14e4c612effd78aff7f04cbdb
https://doi.org/10.1021/acs.jcim.5b00627
https://doi.org/10.1021/acs.jcim.5b00627
Publikováno v:
Journal of Chemical Information and Modeling. 55:538-549
Protein kinases are involved in a variety of diseases including cancer, inflammation, and autoimmune disorders. Although the development of new kinase inhibitors is a major focus in pharmaceutical research, a large number of kinases remained so far u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89a5fa8e8582685f022a585c983391ff
https://doi.org/10.1021/ci500624s
https://doi.org/10.1021/ci500624s
Publikováno v:
European Journal of Medicinal Chemistry. 84:491-504
Development of new antimicrobial agents is a good solution to overcome drug-resistance problems. In this context, new functionalized thiophene, acrylamide, arylhydrazone, pyrazole and pyridone derivatives bearing sulfisoxazole moiety were designed, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1fbcd80f7378aaf985d593a567de3c8
https://doi.org/10.1016/j.ejmech.2014.07.052
https://doi.org/10.1016/j.ejmech.2014.07.052
Publikováno v:
BMC Bioinformatics
Background Annotations of the phylogenetic tree of the human kinome is an intuitive way to visualize compound profiling data, structural features of kinases or functional relationships within this important class of proteins. The increasing volume an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8dea7d8080f3a1038e559b3a83c6d32
https://doi.org/10.1186/s12859-016-1433-7
https://doi.org/10.1186/s12859-016-1433-7