Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sameera Zia"'
Autor:
Ghazaleh Eskandari-Sedighi, Madeline Crichton, Sameera Zia, Erik Gomez-Cardona, Leonardo M. Cortez, Zain H. Patel, Kei Takahashi-Yamashiro, Chris D. St. Laurent, Gaurav Sidhu, Susmita Sarkar, Vivian Aghanya, Valerie L. Sim, Qiumin Tan, Olivier Julien, Jason R. Plemel, Matthew S. Macauley
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-27 (2024)
Abstract Microglia play diverse pathophysiological roles in Alzheimer’s disease (AD), with genetic susceptibility factors skewing microglial cell function to influence AD risk. CD33 is an immunomodulatory receptor associated with AD susceptibility
Externí odkaz:
https://doaj.org/article/e2bd71e630ca42e2903e16f780fc40b0
Autor:
Shima Shahbaz, Eliana Perez Rosero, Hussain Syed, Mark Hnatiuk, Najmeh Bozorgmehr, Amirhossein Rahmati, Sameera Zia, Jason Plemel, Mohammed Osman, Shokrollah Elahi
Publikováno v:
mBio, Vol 15, Iss 8 (2024)
ABSTRACT Hematopoiesis is a tightly regulated process that gets skewed toward myelopoiesis. This restrains lymphopoiesis, but the role of lymphocytes in this process is not well defined. To unravel the intricacies of neutrophil responses in COVID-19,
Externí odkaz:
https://doaj.org/article/9a1be3b74be64450aad5c463cb309fd6
Autor:
Charbel S. Baaklini, Madelene F.S. Ho, Tristan Lange, Brady P. Hammond, Sharmistha P. Panda, Martin Zirngibl, Sameera Zia, Kassandre Himmelsbach, Heli Rana, Braxton Phillips, Daria Antoszko, Jeremies Ibanga, Mizuki Lopez, Kelly V. Lee, Michael B. Keough, Andrew V. Caprariello, Bradley J. Kerr, Jason R. Plemel
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113574- (2023)
Summary: Multiple sclerosis (MS) is an inflammatory disease characterized by myelin loss. While therapies exist to slow MS progression, no treatment currently exists for remyelination. Remyelination, linked to reduced disability in MS, relies on micr
Externí odkaz:
https://doaj.org/article/c6101db6703e4244b13c710b42e758bc
Autor:
Sameera Zia, Brady P. Hammond, Martin Zirngibl, Anastasia Sizov, Charbel S. Baaklini, Sharmistha P. Panda, Madelene F. S. Ho, Kelly V. Lee, Apurba Mainali, Mena K. Burr, Sioned Williams, Andrew V. Caprariello, Christopher Power, Thomas Simmen, Bradley J. Kerr, Jason R. Plemel
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-24 (2022)
Abstract Background Microglia regulate the response to injury and disease in the brain and spinal cord. In white matter diseases microglia may cause demyelination. However, how microglia respond and regulate demyelination is not fully understood. Met
Externí odkaz:
https://doaj.org/article/82452501e5814e46b46a90da3e09d6ab
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-6 (2022)
Microglia “heterogeneity” is often described in the literature, but a clear understanding of what “heterogeneity” entails is essential to avoid confusion among researchers.
Externí odkaz:
https://doaj.org/article/119dbacbdac14e01865dd9a815b9048a
Autor:
Abhishek Bhattacherjee, Jaesoo Jung, Sameera Zia, Madelene Ho, Ghazaleh Eskandari-Sedighi, Chris D. St. Laurent, Kelli A. McCord, Arjun Bains, Gaurav Sidhu, Susmita Sarkar, Jason R. Plemel, Matthew S. Macauley
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-22 (2021)
Abstract Background CD33 is genetically linked to Alzheimer’s disease (AD) susceptibility through differential expression of isoforms in microglia. The role of the human CD33 short isoform (hCD33m), preferentially encoded by an AD-protective CD33 a
Externí odkaz:
https://doaj.org/article/9d903e7fcaaf46188f4b75d343f185d2
Autor:
Sameera Zia, Khalil S. Rawji, Nathan J. Michaels, Mena Burr, Bradley J. Kerr, Luke M. Healy, Jason R. Plemel
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Multiple Sclerosis (MS) is a neurodegenerative disease characterized by multiple focal lesions, ongoing demyelination and, for most people, a lack of remyelination. MS lesions are enriched with monocyte-derived macrophages and brain-resident microgli
Externí odkaz:
https://doaj.org/article/7e764c1892a24efd8333c128f3e43c0f
Autor:
Madelene Ho, Chris D. St. Laurent, Kelli A. McCord, Abhishek Bhattacherjee, Ghazaleh Eskandari-Sedighi, Sameera Zia, Matthew S. Macauley, Jaesoo Jung, Gaurav Sidhu, Jason R. Plemel, Arjun Bains, Susmita Sarkar
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-22 (2021)
Background CD33 is genetically linked to Alzheimer’s disease (AD) susceptibility through differential expression of isoforms in microglia. The role of the human CD33 short isoform (hCD33m), preferentially encoded by an AD-protective CD33 allele (rs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf832cb6f85bf4d28a1c0ce4f84ecb4b
https://doaj.org/article/9d903e7fcaaf46188f4b75d343f185d2
https://doaj.org/article/9d903e7fcaaf46188f4b75d343f185d2
Autor:
Abhishek Bhattacherjee, Jaesoo Jung, Sameera Zia, Ho, Madelene, Ghazaleh Eskandari-Sedighi, Laurent, Chris D. St., McCord, Kelli A., Bains, Arjun, Gaurav Sidhu, Sarkar, Susmita, Plemel, Jason R., Macauley, Matthew S.
Additional file 1: Fig. 1. Quantifying microglia in the brain of human CD33 transgenic mice by immunofluorescence staining. The density of microglia was assessed by the number of IBA1 + cells per mm2 of tissue from the average of a minimum of five se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b207ea0928277a907bea1fe975a67dc
Autor:
Abhishek, Bhattacherjee, Jaesoo, Jung, Sameera, Zia, Madelene, Ho, Ghazaleh, Eskandari-Sedighi, Chris D, St Laurent, Kelli A, McCord, Arjun, Bains, Gaurav, Sidhu, Susmita, Sarkar, Jason R, Plemel, Matthew S, Macauley
Publikováno v:
Molecular Neurodegeneration
Background CD33 is genetically linked to Alzheimer’s disease (AD) susceptibility through differential expression of isoforms in microglia. The role of the human CD33 short isoform (hCD33m), preferentially encoded by an AD-protective CD33 allele (rs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4ddb1344de5ae145530af3b293661d5e
https://pubmed.ncbi.nlm.nih.gov/33766097
https://pubmed.ncbi.nlm.nih.gov/33766097