Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Sameer V. B. Kumar"'
Publikováno v:
Journal of Cellular Biochemistry. 119:4907-4917
Cancer cells exhibit increased dependency on aerobic glycolysis, a phenomenon referred as the "Warburg effect" and therefore, blocking glycolysis by using non-metabolizable analogues of glucose, like 2-Deoxy glucose (2-DG), has been proposed to be of
Publikováno v:
Journal of Cellular Physiology. 233:238-248
Cellular migration is important during many physiological as well as pathological conditions and is regulated very tightly by an intricate network of signaling and effector molecules. One of the important players during cellular migration are matrix
2-Deoxy Glucose Modulates Expression and Biological Activity of VEGF in a SIRT-1 Dependent Mechanism
Autor:
Lincy Edatt, Sameer V. B. Kumar, Perumana R. Sudhakaran, Aswini Poyyakkara, Manikantan Syamala Kiran, Viji Raveendran, Sruthi Thekkeveedu, Haritha Kunhiraman
Publikováno v:
Journal of Cellular Biochemistry. 118:252-262
Reprogramming of energy metabolism particularly switching over of cells to aerobic glycolysis leading to accumulation of lactate is a hallmark of cancer. Lactate can induce angiogenesis, an important process underlying tumor growth and metastasis. VE
Autor:
Grace R. Raji, Sameer V. B. Kumar, Vishnu Ramachandran, S. Sharath Shankar, T. V. Sruthi, Haritha Kunhiraman, Lincy Edatt, Aswini Poyyakkara, Vandana Shankar
Publikováno v:
Journal of cellular physiology. 233(4)
Neo vessel formation by angiogenesis is an important event during many pathological conditions including cancer, where it is indispensable for tumor growth and survival. Although, various pro-angiogenic cytokines and soluble factors, secreted by tumo
2-Deoxy Glucose Modulates Expression and Biological Activity of VEGF in a SIRT-1 Dependent Mechanism
Autor:
Haritha, Kunhiraman, Lincy, Edatt, Sruthi, Thekkeveedu, Aswini, Poyyakkara, Viji, Raveendran, Manikantan Syamala, Kiran, Perumana, Sudhakaran, Sameer V B, Kumar
Publikováno v:
Journal of cellular biochemistry. 118(2)
Reprogramming of energy metabolism particularly switching over of cells to aerobic glycolysis leading to accumulation of lactate is a hallmark of cancer. Lactate can induce angiogenesis, an important process underlying tumor growth and metastasis. VE
Autor:
Perumana R. Sudhakaran, Manikantan Syamala Kiran, Sameer V B Kumar, Raveendran I Viji, Athira A. Prabhakaran
Publikováno v:
Vascular Cell
The mechanism of cell-cell contact dependent regulation of pericellular proteolysis in angiogenesis was examined by studying the expression of MMPs using isolated HUVECs in culture. Zymography, Immunoblot and RT-PCR analysis showed that the productio