Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Sameer S Udhane"'
Autor:
Gargi Basu, Sameer S. Udhane, Susan Dombrowski, Lenny Hong, Fadel Alyaqoub, Michelle Barbi de Moura, Thiruppavai Chandrasekaran, Turgut Dogruluk, David Driscoll, Aimee Jalkanen, Pawan Noel, Szabolcs Szelinger, Min Wang, David Hall, Jess Hoag, Janine Lobello, Frederick Baehner, Snehal Thakkar, Joyce O’Shaughnessy
Publikováno v:
Cancer Research. 83:P5-14
Introduction/Background Endocrine therapy remains the fundamental treatment for advanced HR+ breast cancer (BC). For those patients who become refractory to endocrine therapy, resistance may be associated with mutations, amplifications, and fusions i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce3a12b7528d58bba56a60670917f5fd
https://doi.org/10.1158/1538-7445.sabcs22-p5-14-12
https://doi.org/10.1158/1538-7445.sabcs22-p5-14-12
Autor:
Yunguang Sun, Linna Ge, Sameer S. Udhane, John F. Langenheim, Mary J. Rau, Mollie D. Patton, Alexander J. Gallan, Juan C. Felix, Hallgeir Rui
Publikováno v:
Methods and Protocols, Vol 4, Iss 3, p 47 (2021)
Human coronavirus disease 2019 (COVID-19) is a life-threatening and highly contagious disease caused by coronavirus SARS-CoV-2. Sensitive and specific detection of SARS-CoV-2 viral proteins in tissues and cells of COVID-19 patients will support inves
Externí odkaz:
https://doaj.org/article/3ab456b59ffd4a4d860fe28191dd153a
Autor:
Sameer S. Udhane, Balazs Legeza, Nesa Marti, Damian Hertig, Gaëlle Diserens, Jean-Marc Nuoffer, Peter Vermathen, Christa E. Flück
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Metformin is an antidiabetic drug, which inhibits mitochondrial respiratory-chain-complex I and thereby seems to affect the cellular metabolism in many ways. It is also used for the treatment of the polycystic ovary syndrome (PCOS), the most
Externí odkaz:
https://doaj.org/article/2e71df7527134047b6b90c88fc3b0776
Autor:
Shaheena Parween, Maria Natalia Rojas Velazquez, Sameer S. Udhane, Norio Kagawa, Amit V. Pandey
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Cytochromes P450 located in the endoplasmic reticulum require NADPH cytochrome P450 oxidoreductase (POR) for their catalytic activities. Mutations in POR cause multiple disorders in humans related to the biosynthesis of steroid hormones and also affe
Externí odkaz:
https://doaj.org/article/216fd4229aa54bb8b72fdae71347e5c0
Autor:
Hallgeir Rui, Inna Chervoneva, Edith P. Mitchell, Terry Hyslop, Michael J. Flister, Paul W. Auer, Marluce Bibbo, Juan P. Palazzo, Hai Hu, Craig D. Shriver, Jeffrey A. Hooke, Albert J. Kovatich, Melanie A. Girondo, Chengbao Liu, Yunguang Sun, Sameer S. Udhane, John F. Langenheim, Amy R. Peck, Takahiro Sato, Fransiscus E. Utama, Thai H. Tran
Supplementary Figure 7: Schematic representation of structure of wildtype Stat5a and Stat5b, dominant-negative Stat5 (DN-Stat5) and constitutively-active Stat5 (CA-Stat5) proteins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18fd5c2a584309d95167b06591aa7204
https://doi.org/10.1158/1078-0432.22470567.v1
https://doi.org/10.1158/1078-0432.22470567.v1
Autor:
Hallgeir Rui, Inna Chervoneva, Edith P. Mitchell, Terry Hyslop, Michael J. Flister, Paul W. Auer, Marluce Bibbo, Juan P. Palazzo, Hai Hu, Craig D. Shriver, Jeffrey A. Hooke, Albert J. Kovatich, Melanie A. Girondo, Chengbao Liu, Yunguang Sun, Sameer S. Udhane, John F. Langenheim, Amy R. Peck, Takahiro Sato, Fransiscus E. Utama, Thai H. Tran
Clinical Characteristics of Outcome Cohorts 1 and 2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61411c77efd405e3b7428febd887645f
https://doi.org/10.1158/1078-0432.22470564
https://doi.org/10.1158/1078-0432.22470564
Autor:
Hallgeir Rui, Inna Chervoneva, Edith P. Mitchell, Terry Hyslop, Michael J. Flister, Paul W. Auer, Marluce Bibbo, Juan P. Palazzo, Hai Hu, Craig D. Shriver, Jeffrey A. Hooke, Albert J. Kovatich, Melanie A. Girondo, Chengbao Liu, Yunguang Sun, Sameer S. Udhane, John F. Langenheim, Amy R. Peck, Takahiro Sato, Fransiscus E. Utama, Thai H. Tran
Purpose:Parathyroid hormone-related protein (PTHrP) is required for normal mammary gland development and biology. A PTHLH gene polymorphism is associated with breast cancer risk, and PTHrP promotes growth of osteolytic breast cancer bone metastases.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c1d09158eb3eef0cdd9ff805494f016
https://doi.org/10.1158/1078-0432.c.6527619
https://doi.org/10.1158/1078-0432.c.6527619
Autor:
Inna Chervoneva, Amy R. Peck, Yunguang Sun, Misung Yi, Sameer S. Udhane, John F. Langenheim, Melanie A. Girondo, Julie M. Jorns, Lubna N. Chaudhary, Sailaja Kamaraju, Carmen Bergom, Michael J. Flister, Jeffrey A. Hooke, Albert J. Kovatich, Craig D. Shriver, Hai Hu, Juan P. Palazzo, Marluce Bibbo, Terry Hyslop, Marja T. Nevalainen, Richard G. Pestell, Serge Y. Fuchs, Edith P. Mitchell, Hallgeir Rui
Publikováno v:
JCO Precision Oncology.
PURPOSE T-cell–mediated cytotoxicity is suppressed when programmed cell death-1 (PD-1) is bound by PD-1 ligand-1 (PD-L1) or PD-L2. Although PD-1 inhibitors have been approved for triple-negative breast cancer, the lower response rates of 25%-30% in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c6b9c3bdb89c2dc4415f84fd3183bb1
https://doi.org/10.1200/po.21.00498
https://doi.org/10.1200/po.21.00498
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
All cytochromes P450s in the endoplasmic reticulum rely on P450 oxidoreductase (POR) for their catalytic activities. Mutations in POR cause metabolic disorders of steroid hormone biosynthesis and affect certain drug metabolizing P450 activities. We s
Externí odkaz:
https://doaj.org/article/6f5863fad07e42fcb2244dbfbca6d492
Autor:
Mónica Fernández-Cancio, Norio Kagawa, Núria Camats, Maria Natalia Rojas Velazquez, Sameer S Udhane, Shaheena Parween, Sara Benito-Sanz, Laura Audi, Christa E. Flück, Amit V. Pandey, Juan-Pedro López-Siguero
Publikováno v:
Parween, Shaheena; Fernández-Cancio, Mónica; Benito-Sanz, Sara; Camats, Núria; Rojas Velazquez, Maria Natalia; López-Siguero, Juan-Pedro; Udhane, Sameer S; Kagawa, Norio; Flück Pandey, Christa Emma; Audí, Laura; Pandey, Amit Vikram (2020). Molecular Basis of CYP19A1 Deficiency in a 46,XX Patient With R550W Mutation in POR: Expanding the PORD Phenotype. The journal of clinical endocrinology and metabolism, 105(4), e1272-e1290. Oxford University Press 10.1210/clinem/dgaa076
Context Mutations in cytochrome P450 oxidoreductase (POR) cause a form of congenital adrenal hyperplasia (CAH). We report a novel R550W mutation in POR identified in a 46,XX patient with signs of aromatase deficiency. Objective Analysis of aromatase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::712d2ed777edd2fc51b2e0fe97c9147e
https://doi.org/10.1210/clinem/dgaa076
https://doi.org/10.1210/clinem/dgaa076