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pro vyhledávání: '"Sameer Karnik"'
Autor:
Claudia Maturo, Zuzana Zachar, James F. Marecek, Robert Shorr, Joanna Lem, Sameer Karnik, Paul M. Bingham, Sunita Gupta, Shawn D. Stuart, Robert J. Rodriguez, Alexandra Schauble, Katy Howell, Arin Piramzadian, King Lee
Publikováno v:
Journal of Molecular Medicine. 89:1137-1148
We report the analysis of CPI-613, the first member of a large set of analogs of lipoic acid (lipoate) we have investigated as potential anticancer agents. CPI-613 strongly disrupts mitochondrial metabolism, with selectivity for tumor cells in cultur