An open microfluidic coculture model of fibroblasts and eosinophils to investigate mechanisms of airway inflammation

Autor: Yuting Zeng, Xiaojing Su, Meg G. Takezawa, Paul S. Fichtinger, Ulri N. Lee, Jeffery W. Pippin, Stuart J. Shankland, Fang Yun Lim, Loren C. Denlinger, Nizar N. Jarjour, Sameer K. Mathur, Nathan Sandbo, Erwin Berthier, Stephane Esnault, Ksenija Bernau, Ashleigh B. Theberge

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)

Interactions between fibroblasts and immune cells play an important role in tissue inflammation. Previous studies have found that eosinophils activated with interleukin-3 (IL-3) degranulate on aggregated immunoglobulin G (IgG) and release mediators t

Externí odkaz: https://doaj.org/article/d3aa85d7eef049188e0e43bf31db9464

Platelet association with leukocytes in active eosinophilic esophagitis.

Autor: Kelly A Bartig, Kristine E Lee, Deane F Mosher, Sameer K Mathur, Mats W Johansson

Publikováno v: PLoS ONE, Vol 16, Iss 4, p e0250521 (2021)

We previously demonstrated that the percentage of blood eosinophils that are associated with platelets and thus positive for CD41 (integrin αIIb-subunit) correlates with and predicts peak eosinophil count (PEC) in biopsies of eosinophilic esophagiti

Externí odkaz: https://doaj.org/article/3654d4efcec24de6b16dae98179ec13f

PASSAGE: A PHASE 4, SINGLE-ARM, OPEN-LABEL STUDY TO EVALUATE THE EFFECTIVENESS AND SAFETY OF TEZEPELUMAB IN PATIENTS WITH SEVERE ASTHMA, INCLUDING UNDER-REPRESENTED GROUPS

Autor: NJIRA L LUGOGO, PRAVEEN AKUTHOTA, SAMEER K MATHUR, AUTUMN BURNETTE, KAHARU SUMINO, NIKITA ARYA, NICOLE CLARKE, ANDREW W LINDSLEY, JEAN-PIERRE LLANOS ACKERT, CHRISTOPHER AMBROSE, WILLIAM COOK, BENJAMIN EMMANUEL

Publikováno v: Chest. 162:A37-A40

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4b444620e7dcb516e4dcf76635d1ec71
https://doi.org/10.1016/j.chest.2022.08.023

Molecular anatomy of eosinophil activation by IL5 and IL33

Autor: Joshua M. Mitchell, Justin W. Mabin, Laura K. Muehlbauer, Douglas S. Annis, Sameer K. Mathur, Mats W. Johansson, Alex S. Hebert, Frances J. Fogerty, Joshua J. Coon, Deane F. Mosher

IL5 and IL33 are major activating cytokines that cause circulating eosinophils to polarize, adhere, and release their granule contents. We correlated microscopic features of purified human blood eosinophils stimulated for 10 min with IL5 or IL33 with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b26f3f5c6e09636afba41f549701f691
https://doi.org/10.1101/2022.12.21.521419

Improving Care in Eosinophil-Associated Diseases: A Charter

Autor: David J. Jackson, Praveen Akuthota, Rebeca Andradas, Albert J. Bredenoord, Amanda Cordell, Sarah Gray, Joyce Kullman, Sameer K. Mathur, Ian Pavord, Florence Roufosse, Christian Rubio, Irena Clisson Rusek, Dagmar Simon, Mary Jo Strobel, Tonya Winders

Publikováno v: Advances in therapy, 39(6), 2323-2341. Health Communications Inc.
Jackson, David J; Akuthota, Praveen; Andradas, Rebeca; Bredenoord, Albert J; Cordell, Amanda; Gray, Sarah; Kullman, Joyce; Mathur, Sameer K; Pavord, Ian; Roufosse, Florence; Rubio, Christian; Rusek, Irena Clisson; Simon, Dagmar; Strobel, Mary Jo; Winders, Tonya (2022). Improving Care in Eosinophil-Associated Diseases: A Charter. Advances in therapy, 39(6), pp. 2323-2341. Springer 10.1007/s12325-022-02110-8

Eosinophil-associated diseases (EADs) are a range of heterogeneous conditions in which eosinophils are believed to play a critical pathological role. EADs include common illnesses such as eosinophilic asthma and chronic rhinosinusitis and rare condit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3025b7b37ca18f41f583ad05c6b9c14
https://pure.amc.nl/en/publications/improving-care-in-eosinophilassociated-diseases(8066bfb1-177c-431b-9da6-69002de399b5).html