Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Sambrone A"'
Autor:
Mike Costa, Stefan Krauss, Daniel D. Holsworth, Paul Polakis, Mark Merchant, Dolores Diaz, Edna Choo, Vladimir Korinek, Ondrej Machon, Ron Firestein, Melissa Schutten, Amy Sambrone, Steven Magnuson, Robert A. Blake, Jason Boggs, Jo Waaler, Marinella Callow, Emily Chan, Ted Lau
Supplementary Fig. S2 - PDF file 365K, Tankyrase and receptor tyrosine kinase pathway inhibitor effects on CRC cell line and intestinal organoid growth.(A) Percentage of cells for the indicated three cell lines showing phospho-histone H3 staining as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3671cf9cc3417dafef5febd7161cb4
https://doi.org/10.1158/0008-5472.22397417
https://doi.org/10.1158/0008-5472.22397417
Autor:
Mike Costa, Stefan Krauss, Daniel D. Holsworth, Paul Polakis, Mark Merchant, Dolores Diaz, Edna Choo, Vladimir Korinek, Ondrej Machon, Ron Firestein, Melissa Schutten, Amy Sambrone, Steven Magnuson, Robert A. Blake, Jason Boggs, Jo Waaler, Marinella Callow, Emily Chan, Ted Lau
Supplementary Data PDF file 168K, Supplementary Materials and Methods; Supplementary Figure and Table Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21399da823f5abc615038bcca3202ada
https://doi.org/10.1158/0008-5472.22397423.v1
https://doi.org/10.1158/0008-5472.22397423.v1
Autor:
Mike Costa, Stefan Krauss, Daniel D. Holsworth, Paul Polakis, Mark Merchant, Dolores Diaz, Edna Choo, Vladimir Korinek, Ondrej Machon, Ron Firestein, Melissa Schutten, Amy Sambrone, Steven Magnuson, Robert A. Blake, Jason Boggs, Jo Waaler, Marinella Callow, Emily Chan, Ted Lau
Supplementary Table S1 - PDF file 18K, Tankyrase inhibitor potency and selectivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3068d4183ba918387a3758670ec549d3
https://doi.org/10.1158/0008-5472.22397405.v1
https://doi.org/10.1158/0008-5472.22397405.v1
Autor:
Mike Costa, Stefan Krauss, Daniel D. Holsworth, Paul Polakis, Mark Merchant, Dolores Diaz, Edna Choo, Vladimir Korinek, Ondrej Machon, Ron Firestein, Melissa Schutten, Amy Sambrone, Steven Magnuson, Robert A. Blake, Jason Boggs, Jo Waaler, Marinella Callow, Emily Chan, Ted Lau
PDF file - 58K, G007-LK effects on tumor growth and mouse body weight in xenograft efficacy studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01837cac0b67d9a086e98b54d7a62b5a
https://doi.org/10.1158/0008-5472.22397408.v1
https://doi.org/10.1158/0008-5472.22397408.v1
Autor:
Liang, Jun, Tsui, Vickie, Van Abbema, Anne, Bao, Liang, Barrett, Kathy, Beresini, Maureen, Berezhkovskiy, Leo, Blair, Wade S., Chang, Christine, Driscoll, James, Eigenbrot, Charles, Ghilardi, Nico, Gibbons, Paul, Halladay, Jason, Johnson, Adam, Kohli, Pawan Bir, Lai, Yingjie, Liimatta, Marya, Mantik, Priscilla, Menghrajani, Kapil, Murray, Jeremy, Sambrone, Amy, Xiao, Yisong, Shia, Steven, Shin, Young, Smith, Jan, Sohn, Sue, Stanley, Mark, Ultsch, Mark, Zhang, Birong, Wu, Lawren C., Magnuson, Steven
Publikováno v:
In European Journal of Medicinal Chemistry September 2013 67:175-187
Autor:
Phan, Vernon T., Wu, Xiumin, Cheng, Jason H., Sheng, Rebecca X., Chung, Alicia S., Zhuang, Guanglei, Tran, Christopher, Song, Qinghua, Kowanetz, Marcin, Sambrone, Amy, Tan, Martha, Meng, Y. Gloria, Jackson, Erica L., Peale, Franklin V., Junttila, Melissa R., Ferrara, Napoleone
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2013 Apr 01. 110(15), 6079-6084.
Externí odkaz:
https://www.jstor.org/stable/42590357
Autor:
Kuen Yeap, John S. Wai, Maia Vinogradova, Yu Zhong, Lori Friedman, Xiaojing Wang, Daniel Otwine, Jiangpeng Liao, Nick Ray, James R. Kiefer, Vidhi Mody, Jun Li, Fabien Roussel, Deepak Sampath, Simon Charles Goodacre, Jun Liang, Michelle Nannini, Sharada Labadie, Xiaoping Zheng, Ellen Ingalla, Steven J. Hartman, Birong Zhang, Jae H. Chang, Tao Wang, Yingqing Ran, Jason R. Zbieg, Amy Sambrone, Kwong Wah Lai, Amy Young, Ciara Metcalfe, Neville James Mclean, Robert A. Blake, Tracy Kleinheinz
Publikováno v:
ACS Med Chem Lett
[Image: see text] Estrogen receptor alpha (ERα) is a well-validated drug target for ER-positive (ER+) breast cancer. Fulvestrant is FDA-approved to treat ER+ breast cancer and works through two mechanisms—as a full antagonist and selective estroge
Autor:
Zbieg, Jason R., Liang, Jun, Li, Jun, Blake, Robert A., Chang, Jae, Friedman, Lori, Goodacre, Simon, Hartman, Steven J., Rei Ingalla, Ellen, Kiefer, James R., Kleinheinz, Tracy, Labadie, Sharada, Lai, Tommy, Liao, Jiangpeng, McLean, Nev, Metcalfe, Ciara, Mody, Vidhi, Nannini, Michelle, Ortwine, Daniel F., Ran, Yingqing, Ray, Nick, Roussel, Fabien, Sambrone, Amy, Sampath, Deepak, Vinogradova, Maia, Wai, John, Wang, Tao, Yeap, Kuen, Zhang, Birong, Zheng, Xiaoping, Zhong, Yu, Wang, Xiaojing
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 October 2021 50
Autor:
Martin O'Rourke, Nicholas Charles Ray, Thomas Gelzleichter, Leah Schutt, Ellen Ingalla, Neville James Mclean, Xiaojing Wang, Stephen Daly, Yingqing Ran, Jiangpeng Liao, Tommy Lai, Yu Zhong, Jun Liang, Sharada Labadie, Lori Friedman, Amy Sambrone, Jun Li, Robert A. Blake, Tao Wang, Liu Zhiguo, Birong Zhang, Steven J. Hartman, Jae H. Chang, Wei Zhou, Jane Guan, Vidhi Mody, Jonathan White, Fabien Roussel, Antonio G. DiPasquale, Jason R. Zbieg, Daniel F. Ortwine, Amy Young, James R. Kiefer, Maia Vinogradova, Simon Charles Goodacre, Deepak Sampath, Tracy Kleinheinz, Xiaoping Zheng, Jennifer M. Giltnane, Lorn Kategaya, Ingrid E. Wertz, Matthew Gill, Ciara Metcalfe, Siew Kuen Yeap, John S. Wai, Jason Oeh, Michelle Nannini
Publikováno v:
Journal of medicinal chemistry. 64(16)
Breast cancer remains a leading cause of cancer death in women, representing a significant unmet medical need. Here, we disclose our discovery efforts culminating in a clinical candidate, 35 (GDC-9545 or giredestrant). 35 is an efficient and potent s
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