Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Sambra D. Redick"'
Autor:
Alan G. Derr, Adediwura Arowosegbe, Basanthi Satish, Sambra D. Redick, Natasha Qaisar, Zhiru Guo, Emma Vanderleeden, Melanie I. Trombly, Christina E. Baer, David M. Harlan, Dale L. Greiner, Manuel Garber, Jennifer P. Wang
Publikováno v:
Diabetes. 72:261-274
Identifying the early islet cellular processes of autoimmune type 1 diabetes (T1D) in humans is challenging given the absence of symptoms during this period and the inaccessibility of the pancreas for sampling. In this article, we study temporal even
Autor:
Jennifer P. Wang, Manuel Garber, Dale L. Greiner, David M. Harlan, Christina E. Baer, Melanie I. Trombly, Emma Vanderleeden, Zhiru Guo, Sambra D. Redick, Basanthi Satish, Adediwura Arowosegbe, Alan G. Derr
Identifying the early islet cellular processes of autoimmune type 1 diabetes (T1D) in humans is challenging given the absence of symptoms during this period and the inaccessibility of the pancreas for sampling. Here, we study temporal events in pancr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cf62201a02a2ebac32f4d90240eeab1
https://doi.org/10.2337/figshare.21494751
https://doi.org/10.2337/figshare.21494751
Autor:
Robert A. Hegele, Rita Bottino, Nripesh Prasad, Greg Poffenberger, John T. Walker, Marcela Brissova, Shristi Shrestha, Alvin C. Powers, Jenny Aurielle B. Babon, May Sanyoura, Andrea H. Ramirez, Conrad Reihsmann, Louis H. Philipson, Rachana Haliyur, Sally C. Kent, Sambra D. Redick, David M. Harlan, Radhika Aramandla
Publikováno v:
Journal of the Endocrine Society
Clinical and pathologic heterogeneity in type 1 diabetes is increasingly being recognized. Findings in the islets and pancreas of a 22-year-old male with 8 years of type 1 diabetes were discordant with expected results and clinical history (islet aut
Autor:
Manuel Garber, Rita Bortell, David M. Blodgett, Alan G. Derr, Dale L. Greiner, Sambra D. Redick, Leonard D. Shultz, Agata Jurczyk, David M. Harlan, Alper Kucukural, Jennifer P. Wang, Linda Leehy, Ann R. Rittenhouse
Publikováno v:
The FASEB Journal
Human pancreatic islets engrafted into immunodeficient mice serve as an important model for in vivo human diabetes studies. Following engraftment, islet function can be monitored in vivo by measuring circulating glucose and human insulin; however, it
Autor:
Raymond D. Blind, Xin Tong, David M. Harlan, Shristi Shrestha, Louis H. Philipson, May Sanyoura, Rachana Haliyur, Jill Lindner, Greg Poffenberger, Roland Stein, Shawn Levy, Nripesh Prasad, Marcela Brissova, Rita Bottino, Diane C. Saunders, Alvin C. Powers, Radhika Aramandla, Sambra D. Redick
Using an integrated approach to characterize the pancreatic tissue and isolated islets from a 33-year-old with 17 years of type 1 diabetes (T1D), we found that donor islets contained β cells without insulitis and lacked glucose-stimulated insulin se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b532bea31d10e8d58beb8626067e1178
https://europepmc.org/articles/PMC6307934/
https://europepmc.org/articles/PMC6307934/
Autor:
Maxim N. Artyomov, Rita Bortell, David M. Blodgett, Rapolas Zilionis, Alan G. Derr, Manuel Garber, David M. Harlan, Dale L. Greiner, Sambra D. Redick, Allon M. Klein, Alexey Sergushichev, Jeremy Luban, Chaoxing Yang, Sebastian Kadener
Publikováno v:
Genome research, Cold Spring Harbor, NY : Cold Spring Harbor Laboratory Press, 2016, Vol. 26, Iss. 10, p. 1397-1410
RNA-seq protocols that focus on transcript termini are well suited for applications in which template quantity is limiting. Here we show that, when applied to end-sequencing data, analytical methods designed for global RNA-seq produce computational a
Autor:
Sambra D. Redick, David M. Harlan, Natasha Qaisar, Jennifer P. Wang, Riccardo Racicot, Basanthi Satish, Pranitha Vangala, Agata Jurczyk, Julius O. Nyalwidhe, Dale L. Greiner, Melanie I. Trombly, Michael A. Brehm, Jerry L. Nadler, Rita Bortell
Publikováno v:
Microorganisms
Volume 8
Issue 2
Microorganisms, Vol 8, Iss 2, p 295 (2020)
Volume 8
Issue 2
Microorganisms, Vol 8, Iss 2, p 295 (2020)
Enteroviral infections are implicated in islet autoimmunity and type 1 diabetes (T1D) pathogenesis. Significant &beta
cell stress and damage occur with viral infection, leading to cells that are dysfunctional and vulnerable to destruction. Human
cell stress and damage occur with viral infection, leading to cells that are dysfunctional and vulnerable to destruction. Human
Autor:
Pia Leete, Jason M. Spaeth, Lars Krogvold, David M. Harlan, Rita Bottino, Marcela Brissova, Alper Kucukural, Sally C. Kent, David M. Blodgett, Alvin C. Powers, Noel G. Morgan, Knut Dahl-Jørgensen, Mark Russell, Jenny Aurielle B. Babon, Rachana Haliyur, Manuel Garber, Sarah J. Richardson, Chaoxing Yang, Sambra D. Redick, Alan G. Derr
Publikováno v:
Diabetes
Type 1 diabetes studies consistently generate data showing islet β-cell dysfunction and T cell–mediated anti-β-cell–specific autoimmunity. To explore the pathogenesis, we interrogated the β-cell transcriptomes from donors with and without type
Publikováno v:
Cell systems. 3(4)
Although the function of the mammalian pancreas hinges on complex interactions of distinct cell types, gene expression profiles have primarily been described with bulk mixtures. Here we implemented a droplet-based, single-cell RNA-seq method to deter
Autor:
Sambra D. Redick, Carlos Murga-Zamalloa, Hemant Khanna, Sebastian Patzke, Stephen J. Doxsey, Abdirashid Warsame, Trond Stokke
Publikováno v:
Molecular Biology of the Cell
CSPP and CSPP-L are centrosomal proteins of known mitotic function. Here, we identify CSPP proteins as ciliary proteins and place them into a NPHP protein network crucial for normal cilia-dependent renal and retinal tissue architecture. Importantly,