Large-scale antibody immune response mapping of splenic B cells and bone marrow plasma cells in a transgenic mouse model

Autor: Xiaoli Pan, Sheila N. López Acevedo, Camille Cuziol, Evelyn De Tavernier, Ahmed S. Fahad, Priyobarta S. Longjam, Sambasiva P. Rao, David Aguilera-Rodríguez, Mathilde Rezé, Christine A. Bricault, Matías F. Gutiérrez-González, Matheus Oliveira de Souza, Joshua M. DiNapoli, Emmanuelle Vigne, Melody A. Shahsavarian, Brandon J. DeKosky

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Molecular characterization of antibody immunity and human antibody discovery is mainly carried out using peripheral memory B cells, and occasionally plasmablasts, that express B cell receptors (BCRs) on their cell surface. Despite the importance of p

Externí odkaz: https://doaj.org/article/49fb3a23f5d142acb94df6b620d91928

A platform-agnostic, function first-based antibody discovery strategy using plasmid-free mammalian expression of antibodies

Autor: Ruijun Zhang, Ponraj Prabakaran, Xiaocong Yu, Brian C. Mackness, Ekaterina Boudanova, Joern Hopke, Jose Sancho, Jacqueline Saleh, HyunSuk Cho, Ningning Zhang, Helene Simonds-Mannes, Samuel D. Stimple, Dietmar Hoffmann, Anna Park, Partha S. Chowdhury, Sambasiva P. Rao

Publikováno v: mAbs, Vol 13, Iss 1 (2021)

Hybridoma technology has been valuable in the development of therapeutic antibodies. More recently, antigen-specific B-cell selection and display technologies are also gaining importance. A major limitation of these approaches used for antibody disco

Externí odkaz: https://doaj.org/article/a782d91bddb64de78fcdc7be4359ef09

LY293111 Improves Efficacy of Gemcitabine Therapy on Pancreatic Cancer in a Fluorescent Orthotopic Model in Athymic Mice

Autor: Rene Hennig, Jacinthe Ventura, Ralf Segersvard, Erin Ward, Xian-Zhong Ding, Sambasiva M. Rao, Borko D. Jovanovic, Takeshi Iwamura, Mark S. Talamonti, Richard H. Bell Jr., Thomas E. Adrian

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 7, Iss 4, Pp 417-425 (2005)

Pancreatic cancer has an abysmal prognosis because of late diagnosis and lack of effective therapeutics. New drugs are desperately needed. The present study determined the effect of the LTB4 receptor antagonist, LY293111, on tumor growth and metastas

Externí odkaz: https://doaj.org/article/7409dab6a7374b29ab320843ba80de51

Integrative Analysis Reveals a Molecular Stratification of Systemic Autoimmune Diseases

Autor: Isabel Almeida, Divi Cornec, Torsten Witte, Tania F. Rowley, Tianlu Li, Elena Carnero-Montoro, Mariana Brandão, Antonio Garcia-Gomez, Nancy Azevedo, Esmeralda Neves, Ana Lisa Taylor Tavares, Ana Campar, Jacques-Olivier Pers, Nicolas Hunzelmann, Ellen De Langhe, Ernst R. Dow, Magdolna Deák, Jorge Kageyama, Francisco Javier Garrancho, Gerard Espinosa, Carlo Chizzolini, Laleh Khodadadi, Falk Hiepe, Maria Angeles Aguirre-Zamorano, Marta E. Alarcón-Riquelme, Rosario Lopez-Pedrera, Anne Buttgereit, Ricard Cervera, Javier Rodríguez-Ubreva, Fernanda Genre, Jerome Wojcik, Begoña Ubilla Garcia, Héctor Navarro-Linares, Maria Orietta Borghi, N.T. Baerlecken, Katja Kniesch, Yolanda Jiménez Gómez, Zuzanna Makowska, Martin Kerick, Elena Trombetta, Pierre-Emmanuel Jouve, Lorenzo Beretta, Ricardo Blanco Alonso, Bénédicte Rouvière, Isabel Díaz Quintero, Michael Zauner, Ralf Lesche, Daniel Toro-Domínguez, Manuel Rodriguez Maresca, Attila Balog, Pier Luigi Meroni, Qingyu Cheng, Georg Stummvoll, Johan Frostegård, Javier Martín, Márta Bocskai, Joerg Mueller, Tommaso Schioppo, Chris Chamberlain, Sonja Dulic, László Kovács, Raquel López Mejías, Velia Gerl, Francesc Català-Moll, Robert J. Benschop, Sara Remuzgo, Carolina Artusi, María Teruel, Eduardo Collantes-Estevez, Miguel A. González-Gay, Silvia Thiel, Bernard Lauwerys, Maria Gerosa, Yves Renaudineau, Pedro Carmona-Sáez, Raquel Faria, Rocío Aguilar-Quesada, Sepideh Babaei, Nuria Barbarroja, Maria Hernandez-Fuentes, María Concepción Fernández Roldán, Sambasiva P. Rao, Aurélie De Groof, Montserrat Alvarez, Anne-Lise Maudoux, Sikander Hayat, Guillermo Barturen, Maria Juarez, Damiana Álvarez-Errico, Alfonso Corrales Martínez, Julie Ducreux, Lucas Le Lann, Norberto Ortego, Jacqueline Marovac, Sandrine Jousse-Joulin, Enrique Raya, Laurence Laigle, Concepción Marañón, Esteban Ballestar, Manuel Martínez-Bueno, Barbara Vigone, Rik Lories, Doreen Belz, Gabriella Kádár, Gaia Montanelli, Fátima Farinha, Divya Thiagaran, M.C. Castro-Villegas, Christophe Jamin, Alain Saraux, Carlos Vasconcelos, Emanuele de Rinaldis, Donatienne Wynar, Enrique de Ramón, Antonio López-Berrio, Tania Anjos, Alejandro Escudero-Contreras, Ian White, Valérie Devauchelle-Pensec, Ignasi Rodríguez-Pintó, Nieves Varela, Quentin Simon, Michaela Lehner, Inmaculada Jiménez Moleón, Aleksandra Maria Dufour, Rafaela Ortega-Castro, Marialbert Acosta-Herrera, Mcdonald Fiona Mcdougall, Yiannis Ioannou, Jonathan Cremer, António Marinho, Jordi Martorell-Marugán

Publikováno v: Arthritis and Rheumatism
Arthritis and Rheumatism, Wiley, 2020, ⟨10.1002/art.41610⟩
Arthritis and Rheumatism, 2020, ⟨10.1002/art.41610⟩
Arthritis & rheumatology, Vol. 73, no.6, p. 1073-1085 (2021)

OBJECTIVE: Clinical heterogeneity, a hallmark of systemic autoimmune diseases, impedes early diagnosis and effective treatment, issues that may be addressed if patients could be classified into groups defined by molecular pattern. This study was unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1563952d4b64a5f243c20fd857065753
https://hdl.handle.net/10668/17043

Pathology in Patients with Chronic Liver Disease: A Practical Approach to Liver Biopsy Interpretation in Patients with Acute and Chronic Liver Diseases

Autor: Audrey, Deeken-Draisey, Sambasiva M, Rao, Guang-Yu, Yang

Publikováno v: Clinics in liver disease. 24(3)

Liver biopsy and histologic examination are the mainstay for diagnosing liver diseases, despite advances in imaging and molecular procedures. Liver biopsy can provide useful information regarding the structural integrity and type and degree of injury

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8d4c3340c313ee0802c900f5ef582390
https://pubmed.ncbi.nlm.nih.gov/32620277