Strengthening and expanding capacities in clinical trials: advancing pandemic prevention, preparedness and response in Africa

Autor: Nicaise Ndembi, Tadesse T. Mekonen, Morenike Oluwatoyin Folayan, Nebiyu Dereje, Adriaan Kruger, Joseph Fokam, Elvis Temfack, Tajudeen Raji, Jean Nachega, Yap Boum, Trevor A. Crowell, Alain Ngashi Ngongo, Souleymane Mboup, Francine Ntoumi, Glaudina Loots, Michael Makanga, Samba Sow, Salim Abdool Karim, John Nkengasong

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-6 (2024)

Enhancing the clinical trial capabilities within Africa is essential to augment the continent’s pandemic prevention, preparedness and response efforts. Here, we describe the critical challenges of clinical trials in Africa and draw upon the lessons

Externí odkaz: https://doaj.org/article/f901b011571e44ce8aaf29e66b9abf00

Prevalence and perception of pre-morbid lifestyle-related risk factors among covid-19 survivors in Lagos state and Abuja capital city of Nigeria

Autor: Ifeoma N Monye, Tijani Idris Ahmad Oseni, Moyosore T. Makinde, Abiodun B. Adelowo, Safiya Yahaya-Kongoila, Marvellous C. Njoku-Adeleke, Aramide Oteju, Samba Nyirenda, Temitayo O. Elebiyo, Ijeoma Judith Dozie, Chinasa T. Ugwuegbulem-Amadi

Publikováno v: BMC Public Health, Vol 24, Iss 1, Pp 1-13 (2024)

Abstract Introduction This study investigated the prevalence and perception of premorbid lifestyle-related risk factors among Covid-19 Survivors in Abuja and Lagos, Nigeria. Methodology A cross-sectional descriptive survey design was used to collect

Externí odkaz: https://doaj.org/article/121139d1495a4dd48f66f508234092ce

Safety, reactogenicity, and immunogenicity of ZR-202-CoV and ZR-202a-CoV recombinant vaccines compared with ComirnatyⓇ: A randomized, observer-blind, controlled, phase 1 study

Autor: Samba O. Sow, Milagritos D. Tapia, Fadima C. Haidara, Fatoumata Diallo, Xi Han, Jingjing Chen, Lei Shi, Qing Yang, Bangwei Yu, Yalin Hu, Lin Yuan, Ge Liu, Silvia Grappi, Martina Monti, Simonetta Viviani, Min Ji, Chenliang Zhou

Publikováno v: International Journal of Infectious Diseases, Vol 148, Iss , Pp 107237- (2024)

ABSTRACT: Objectives: ZR-202-CoV and ZR-202a-CoV are novel recombinant vaccines containing 25 µg of the prototype (Wuhan strain) or B.1.351 strain (Beta variant) SARS-CoV-2 S-protein expressed in CHO cells, respectively, adjuvanted with Al(OH)3 and

Externí odkaz: https://doaj.org/article/d83f07053f0049fca3287337bb1a471c

Antimicrobial and anticancer activities of diazenyl compounds

Autor: Seynabou Sokhna, Insa Seck, Marc Presset, Eric Huet, Samba Fama Ndoye, Lalla Aïcha Ba, Issa Samb, Erwan Le Gall, Matar Seck

Publikováno v: Results in Chemistry, Vol 10, Iss , Pp 101749- (2024)

Three heterocyclic diazenyl compounds were synthesized by diazotization of 3-aminopyridine and aniline, followed by coupling with 8-aminoquinoleine, morpholine, 1,2,3,4-tetrahydroquinoleine, respectively. The obtained azo compounds are brown to yello

Externí odkaz: https://doaj.org/article/f5059bfcbb17433aa74a4ab2c3526d13

Clinicopathological discrepancies in the diagnoses of childhood causes of death in the CHAMPS network: An analysis of antemortem diagnostic inaccuracies

Autor: Khatia Munguambe, Quique Bassat, Robert F Breiman, Mahbubur Rahman, Sibone Mocumbi, Cynthia G Whitney, Amy Wise, Shams El Arifeen, Meerjady Sabrina Flora, Soter Ameh, Emily S Gurley, Mustafizur Rahman, Ariel Nhacolo, Carla Carrilho, Cheick Bougadari Traore, Lucy Liu, Inacio Mandomando, Clara Menendez, Chris A Rees, Janet Agaya, Jane Juma, Tadesse Gure, George Aol, Hennie Lombaard, Ziyaad Dangor, Shabir Madhi, James Bunn, Samba O Sow, Dickson Gethi, Sanwarul Bari, Jeffrey P Koplan, Natalia Rakislova, Fabiola Fernandes, Tacilta Nhampossa, Maria Maixenchs, Mohammed Kamal, Nega Assefa, Joseph Oundo, Lola Madrid, Tahmina Shirin, Nelesh P Govender, Addisu Alemu, Hailemariam Legesse, Uma U Onwuchekwa, Awa Traore, Portia C Mutevedzi, Victor Akelo, Sammy Khagayi, Dickens Onyango, Richard Omore, Yasmin Adam, Peter Otieno, Margaret Mannah, Vicky Baillie, Karen L Kotloff, John Blevins, Milagritos D Tapia, Rima Koka, Mohammad Zahid Hossain, Dickens Kowuor, Tom Sesay, James Squire, Francis Moses, Haleluya Leulseged, Christine Bethencourt, Kitiezo Aggrey Igunza, Ikechukwu U Ogbuanu, Andrew Moseray, Ima-Abasi Bassey, Afruna Rahman, Muntasir Alam, Yasir Y Abdullahi, Nana Kourouma, Seydou Sissoko, Rosauro Varo, Sana Mahtab, Martin Hale, Jeanie du Toit, Zachary J Madewell, Dianna M Blau, Roosecelis B Martines, Fatima Solomon, Gillian Sorour, Jeannette Wadula, Karen Petersen, Peter J Swart, Sanjay G Lala, Sithembiso Velaphi, Richard Chawana, Ashleigh Fritz, Nellie Myburgh, Pedzisai Ndagurwa, Cleopas Hwinya, Shahana Parveen, ASM Nawshad Uddin Ahmed, Mahbubul Hoque, Saria Tasnim, Ferdousi Islam, Farida Ariuman, Mohammad Mosiur Rahman, Ferdousi Begum K Zaman, Dilruba Ahmed, Alexander M Ibrahim, Fikremelekot Temesgen, Melisachew Mulatu Yeshi, Mahlet Abayneh Gizaw, Stian MS Orlien, Solomon Ali, Peter Nyamthimba Onyango, Richard Oliech, Joyce Akinyi Were, Thomas Misore, Harun Owuor, Christopher Muga, Bernard Oluoch, Christine Ochola, Sharon M Tennant, Carol L Greene, Ashka Mehta, J Kristie Johnson, Brigitte Gaume, Adama Mamby Keita, Karen D Fairchild, Diakaridia Kone, Diakaridia Sidibe, Doh Sanogo, Kounandji Diarra, Tiéman Diarra, Kiranpreet Chawla, Zara Manhique, Fatmata Bintu Tarawally, Martin Seppeh, Ronald Mash, Julius Ojulong, Babatunde Duduyemi, Alim Swaray-Deen, Joseph Bangura Amara Jambai, Okokon Ita, Cornell Chukwuegbo, Sulaiman Sannoh, Princewill Nwajiobi, Erick Kaluma, Oluseyi Balogun, Carrie Jo Cain, Solomon Samura, Samuel Pratt, Joseph Kamanda Sesay, Osman Kaykay, Binyam Halu, Francis Smart, Sartie Kenneh, Jana Ritter, Tais Wilson, Jonas Winchell, Jakob Witherbee, Navit T Salzberg, Margaret Basket, Ashutosh Wadhwa, Kyu Han Lee, Roosecelis Martines, Shamta Warang, Maureen Diaz, Jessica Waller, Shailesh Nair, Courtney Bursuc, Kristin LaHatte, Sarah Raymer, Solveig Argeseanu, Kurt Vyas, Manu Bhandari

Publikováno v: BMJ Paediatrics Open, Vol 8, Iss 1 (2024)

Introduction Determining aetiology of severe illness can be difficult, especially in settings with limited diagnostic resources, yet critical for providing life-saving care. Our objective was to describe the accuracy of antemortem clinical diagnoses

Externí odkaz: https://doaj.org/article/d37c6c24b1bb4fc5926b6da8646eb57d