Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Samarpan, Majumder"'
Autor:
Fokhrul Hossain, Deniz A. Ucar, Giulia Monticone, Yong Ran, Samarpan Majumder, Kristina Larter, Hanh Luu, Dorota Wyczechowska, Soroor Heidari, Keli Xu, Sudarvili Shanthalingam, Margarite Matossian, Yaguang Xi, Matthew Burow, Bridgette Collins-Burow, Luis Del Valle, Chindo Hicks, Jovanny Zabaleta, Todd Golde, Barbara Osborne, Lucio Miele
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionTriple-negative breast cancer (TNBC) comprises a heterogeneous group of clinically aggressive tumors with high risk of recurrence and metastasis. Current pharmacological treatment options remain largely limited to chemotherapy. Despite pr
Externí odkaz:
https://doaj.org/article/04b72879c8aa4137addccea9bc2f8f2b
Targeting the Cbl-b-Notch1 axis as a novel immunotherapeutic strategy to boost CD8+ T-cell responses
Autor:
Giulia Monticone, Zhi Huang, Fred Csibi, Silvana Leit, David Ciccone, Ameya S. Champhekar, Jermaine E. Austin, Deniz A. Ucar, Fokhrul Hossain, Salome V. Ibba, A. Hamid Boulares, Nicholas Carpino, Keli Xu, Samarpan Majumder, Barbara A. Osborne, Christine Loh, Lucio Miele
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
A critical feature of cancer is the ability to induce immunosuppression and evade immune responses. Tumor-induced immunosuppression diminishes the effectiveness of endogenous immune responses and decreases the efficacy of cancer immunotherapy. In thi
Externí odkaz:
https://doaj.org/article/f8e940e37817407f8336c28c349fbf51
Autor:
Julie Means-Powell, Luis Del Valle, Vandana G. Abramson, Claudia Sorrentino, Melinda Sanders, Ingrid A. Mayer, Debra A. Tonetti, Roohi Ismail-Khan, Samarpan Majumder, Richard M Lush, Lucio Miele
Publikováno v:
Clin Breast Cancer
Preclinical studies have demonstrated a complex cross-talk between Notch and estrogen signaling in ERα-positive breast cancer. Gamma-secretase inhibitors (GSIs) are investigational agents that block the cleavage and activation of Notch receptors. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3938287bbd872fd8ccef6088777a01dc
https://doi.org/10.1016/j.clbc.2021.10.013
https://doi.org/10.1016/j.clbc.2021.10.013
Autor:
Fokhrul Hossain, Samarpan Majumder, Deniz A. Ucar, Paulo C. Rodriguez, Todd E. Golde, Lisa M. Minter, Barbara A. Osborne, Lucio Miele
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Cancer immunotherapy, which stimulates or augments host immune responses to treat malignancies, is the latest development in the rapidly advancing field of cancer immunology. The basic principles of immunotherapies are either to enhance the functions
Externí odkaz:
https://doaj.org/article/43007cad3d39406fad720a3813534bd6
Autor:
Barbara A. Osborne, Judy S. Crabtree, Lucio Miele, Samarpan Majumder, Lisa M. Minter, Todd E. Golde
Publikováno v:
Nature Reviews Drug Discovery. 20:125-144
Notch signalling is involved in many aspects of cancer biology, including angiogenesis, tumour immunity and the maintenance of cancer stem-like cells. In addition, Notch can function as an oncogene and a tumour suppressor in different cancers and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a201ee86b0c6cb5da4e6cfa349f3acc9
https://doi.org/10.1038/s41573-020-00091-3
https://doi.org/10.1038/s41573-020-00091-3
Autor:
Giulia Monticone, Fred Csibi, Silvana Leit, David Ciccone, Ameya S. Champhekar, Jermaine E. Austin, Deniz A. Ucar, Fokhrul Hossain, Zhi Huang, Salome V. Ibba, A. Hamid Boulares, Nicholas Carpino, Samarpan Majumder, Keli Xu, Barbara A. Osborne, Christine Loh, Lucio Miele
A critical feature of cancer is the ability to induce immunosuppression and evade immune responses. Tumor-induced immunosuppression diminishes the efficacy of endogenous immune responses and decreases the efficacy of cancer immunotherapy. In this stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f1499160016e9fd40cbe8738775d92d
https://doi.org/10.1101/2022.03.15.484378
https://doi.org/10.1101/2022.03.15.484378
Publikováno v:
Nutrients
Volume 13
Issue 10
Nutrients, Vol 13, Iss 3656, p 3656 (2021)
Volume 13
Issue 10
Nutrients, Vol 13, Iss 3656, p 3656 (2021)
Triple-negative breast cancer (TNBC) is an aggressive, molecularly heterogeneous subtype of breast cancer. Obesity is associated with increased incidence and worse prognosis in TNBC through various potential mechanisms. Recent evidence suggests that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f2b5f82ce455afc3490a5d23e3673f7
Autor:
Barbara A. Osborne, Keli Xu, Todd E. Golde, Fokhrul Hossain, Yaguang Xi, Deniz A. Ucar, Samarpan Majumder, Lisa M. Minter, Lucio Miele, Yong Ran, Matthew E. Burow
Publikováno v:
Cancer Research. 79:P6-22
Triple negative breast cancer (TNBC) is a heterogeneous group of clinically aggressive breast cancers. TNBC patients have a high risk of recurrence and metastasis, and current treatment options remain limited. There is strong evidence supporting the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::111b4b038f4800ccbd94abecd16cd894
https://doi.org/10.1158/1538-7445.sabcs18-p6-22-01
https://doi.org/10.1158/1538-7445.sabcs18-p6-22-01
Publikováno v:
Cancer Research. 79:P4-07
The Notch signaling pathway plays a central role in cellular differentiation, growth and stem cell maintenance. Expression and activation of Notch pathway receptors and ligands have differential outcomes depending on the tissue, localization and cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::350a27308fb503c3123f04032c0caa1a
https://doi.org/10.1158/1538-7445.sabcs18-p4-07-05
https://doi.org/10.1158/1538-7445.sabcs18-p4-07-05
Publikováno v:
Cancers, Vol 13, Iss 3739, p 3739 (2021)
Cancers
Cancers
Simple Summary The implementation of precision medicine will revolutionize cancer treatment paradigms. Notably, this goal is not far from reality: genetically similar cancers can be treated similarly. The heterogeneous nature of triple-negative breas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bac8d28e78e3311eb8ddde4d8d8c720
https://www.mdpi.com/2072-6694/13/15/3739
https://www.mdpi.com/2072-6694/13/15/3739