Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Samar S. Tawfik"'
1
Akademický článek
New oxadiazole and pyrazoline derivatives as anti-proliferative agents targeting EGFR-TK: design, synthesis, biological evaluation and molecular docking study
Autor: Marwa I. Serag, Samar S. Tawfik, Sahar M. I. Badr, Hassan M. Eisa
Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Two new series of oxadiazole and pyrazoline derivatives were designed and synthesized as promising EGFR-TK inhibitors. The in vitro antiproliferative activity was studied against three human cancer cell lines; HCT116, HepG-2 and MCF7 using M
Externí odkaz: https://doaj.org/article/6284f0a0aa3541e7984ea263ae2507cf
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2
Akademický článek
Identification of Benzothiazoles Bearing 1,3,4-Thiadiazole as Antiproliferative Hybrids Targeting VEGFR-2 and BRAF Kinase: Design, Synthesis, BIO Evaluation and In Silico Study
Autor: Wafaa A. Ewes, Samar S. Tawfik, Aya M. Almatary, Mashooq Ahmad Bhat, Hamed W. El-Shafey, Ahmed A. B. Mohamed, Abdullah Haikal, Mohammed A. El-Magd, Abdullah A. Elgazar, Marwa Balaha, Abdelrahman Hamdi
Publikováno v: Molecules, Vol 29, Iss 13, p 3186 (2024)
Cancer remains a leading cause of death worldwide, often resulting from uncontrolled growth in various organs. Protein kinase inhibitors represent an important class of targeted cancer therapies. Recently, the kinases BRAF and VEGFR-2 have shown syne
Externí odkaz: https://doaj.org/article/a4915b3b03014f48954ca3fc6a3d2663
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3
Akademický článek
New benzothiazole hybrids as potential VEGFR-2 inhibitors: design, synthesis, anticancer evaluation, and in silico study
Autor: Mohammad M. Al-Sanea, Abdelrahman Hamdi, Ahmed A. B. Mohamed, Hamed W. El-Shafey, Mahmoud Moustafa, Abdullah A. Elgazar, Wagdy M. Eldehna, Hidayat Ur Rahman, Della G. T. Parambi, Rehab M. Elbargisy, Samy Selim, Syed Nasir Abbas Bukhari, Omnia Magdy Hendawy, Samar S. Tawfik
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
A new series of 2-aminobenzothiazole hybrids linked to thiazolidine-2,4-dione 4a–e, 1,3,4-thiadiazole aryl urea 6a–d, and cyanothiouracil moieties 8a–d was synthesised. The in vitro antitumor effect of the new hybrids was assessed against three
Externí odkaz: https://doaj.org/article/33b1c246c9694ebf90ed1bf2f5e360ba
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4
Akademický článek
Identification of new benzimidazole-triazole hybrids as anticancer agents: multi-target recognition, in vitro and in silico studies
Autor: Dina I. A. Othman, Abdelrahman Hamdi, Samar S. Tawfik, Abdullah A. Elgazar, Amany S. Mostafa
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Multi-target inhibitors represent useful anticancer agents with superior therapeutic attributes. Here in, two novel series of benzimidazole-triazole hybrids were designed, synthesised as multi-target EGFR, VEGFR-2 and Topo II inhibitors, and evaluate
Externí odkaz: https://doaj.org/article/19091a4a39dc48c488a42b98d4cbbb79
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5
Akademický článek
Design, synthesis, and biological investigation of oxadiazolyl, thiadiazolyl, and pyrimidinyl linked antipyrine derivatives as potential non-acidic anti-inflammatory agents
Autor: Mohammad M. Al-Sanea, Abdelrahman Hamdi, Simone Brogi, Samar S. Tawfik, Dina I. A. Othman, Mahmoud Elshal, Hidayat Ur Rahman, Della G. T. Parambi, Rehab M. Elbargisy, Samy Selim, Ehab M. Mostafa, Ahmed A. B. Mohamed
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
A novel series of 12 antipyrine derivatives containing 1,3,4-oxadiazoles (4a-d), 1,3,4-thiadiazoles (6a-d), and pyrimidines (8a-d), was preparedand assessed for its potential in vitro COX-2 inhibitors. Compared to Celecoxib, compounds 4b-d and 8d wer
Externí odkaz: https://doaj.org/article/81d6be4508e84755a23af8c5f039439b
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8
Akademický článek
Synthesis, in-silico, and in-vitro study of novel chloro methylquinazolinones as PI3K-δ inhibitors, cytotoxic agents
Autor: Sherin M. Elfeky, Samar J. Almehmadi, Samar S. Tawfik
Publikováno v: Arabian Journal of Chemistry, Vol 15, Iss 2, Pp 103614- (2022)
Through a two-step procedure, 3-amino-7-chloro-2-methylquinazolin-4(3H)-one was synthesized from 2-amino-4-chlorobenzoic acid as a starting material. The latter reacted with chloro acetylchloride, then nucleophilically substituted with various second
Externí odkaz: https://doaj.org/article/8d756dfdfc524ef5bef91a45de69f054
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9
Akademický článek
1,3,4-Oxadiazole N-Mannich Bases: Synthesis, Antimicrobial, and Anti-Proliferative Activities
Autor: Lamya H. Al-Wahaibi, Ahmed A. B. Mohamed, Samar S. Tawfik, Hanan M. Hassan, Ali A. El-Emam
Publikováno v: Molecules, Vol 26, Iss 8, p 2110 (2021)
The reaction of 5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazole-2(3H)-thione 3 with formaldehyde solution and primary aromatic amines or 1-substituted piperazines, in ethanol at room temperature yielded the corresponding N-Mannich bases 3-arylaminomethyl-5-
Externí odkaz: https://doaj.org/article/b2d98eb3030e4bc6a9ed3e7ae77b848f
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