Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Samar Hamdy"'
Autor:
Aws Alshamsan, Samar Hamdy, Saswati Das Saswati Das, Afsaneh Lavasanifar, John Samuel, Ayman O.S. El-Kadi
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 13, Iss 1 (2010)
PURPOSE: Tumors can escape immune eradication by harnessing dendritic cell (DC) maturation. However, DC types used as in vitro models to study tumor-mediated immunosuppression possess fundamental variability that could influence research outcomes. Th
Externí odkaz:
https://doaj.org/article/c9eff949ed4c4a39b441cd9515a55002
Publikováno v:
Current Drug Delivery. 8:274-281
The interaction of dendritic cells (DCs) and T cells has been the cornerstone of approaches to cancer immunotherapy. Antitumoral immune responses can be elicited by delivering cancer antigens to DCs. As antigen presenting cells, these DCs activate ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e6f111f24ee94d96485f913fdb9b25b
https://doi.org/10.2174/156720111795256219
https://doi.org/10.2174/156720111795256219
Publikováno v:
Current Drug Delivery. 8:261-273
Dendritic cells (DCs) are the key antigen presenting cells that link innate and adaptive immunity. In the periphery, DCs capture antigens, process them and migrate into the regional lymph nodes where they could initiate antigen specific T cell immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a012671ea1cc92ec31d2cb700583d8fb
https://doi.org/10.2174/156720111795256101
https://doi.org/10.2174/156720111795256101
Publikováno v:
Journal of Drug Targeting. 19:281-292
The purpose of this study was to identify an optimum targeted particulate formulation based on mannan (MN)-decorated poly(D, L-lactide-co-glycolide) (PLGA) nanoparticles (NPs), for efficient delivery of incorporated cargo to dendritic cells (DCs). In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634465163d8b03ee82891dda13ed233a
https://doi.org/10.3109/1061186x.2010.499463
https://doi.org/10.3109/1061186x.2010.499463
Publikováno v:
Immunopharmacology and Immunotoxicology. 31:214-221
The efficiency of cancer immunotherapy strategies is hampered by the existence of an intra-tumoral immunosuppressive environment involving tolerogenic dendritic cells (DCs) and regulatory T (T(reg)) cells. Hyperactivation of STAT3 in tumor is implica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bdb989d92d59776731595cd66281355
https://doi.org/10.1080/08923970802380452
https://doi.org/10.1080/08923970802380452
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 44:914-923
The present study had two main objectives. First, was to compare the immune stimulatory effect of two synthetic lipid A analogues (7-acyl lipid A and pentaerythritol-based lipid A (PET lipid A)) on maturation/stimulation of bone marrow derived dendri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ec7346ccef07c9cb8399b2d5819eb19
https://doi.org/10.1016/j.jpba.2007.03.010
https://doi.org/10.1016/j.jpba.2007.03.010
Publikováno v:
International Journal of Scientific Reports. 3:110
Background: Diabetic nephropathy (DN) has become one of the most common causes of end stage renal disease (ESRD). Hyperglycemia induces oxidative stress in renal tubular epithelial cells that initiate tubulointerstitial fibrosis, which is a character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe26c461a151e1a1fe1e7494fce4f513
https://doi.org/10.18203/issn.2454-2156.intjscirep20171997
https://doi.org/10.18203/issn.2454-2156.intjscirep20171997
Publikováno v:
Nanotechnology. 25(35)
Mannan (MN) is the natural ligand for mannose receptors, which are widely expressed on dendritic cells (DCs). The purpose of this study was to assess the effect of formulation parameters on the immunogenicity of MN-decorated poly (D, L-lactide-co-gly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e829327a52cec274f7d3ffa25fb98ad
https://pubmed.ncbi.nlm.nih.gov/25119543
https://pubmed.ncbi.nlm.nih.gov/25119543
Autor:
Anooshirvan Shayeganpour, Samar Hamdy, Afsaneh Lavasanifar, Azita Haddadi, Aws Alshamsan, Hamidreza Montazeri Aliabadi
Publikováno v:
The AAPS journal. 13(2)
We have previously developed micelles of methoxy poly(ethylene oxide)-b-poly(e-caprolactone) as vehicles for the solubilization and delivery of cyclosporine A (CsA). These micelles were able to reduce the renal uptake and nephrotoxicity of CsA. The p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0af9ff8ee364ebe8be15b1c419f962
https://pubmed.ncbi.nlm.nih.gov/21336534
https://pubmed.ncbi.nlm.nih.gov/21336534
Autor:
Ryan W. Hung, John Samuel, Afsaneh Lavasanifar, Samar Hamdy, Raymond Lai, Ommoleila Molavi, Abdullah Mahmud
Publikováno v:
Molecular pharmaceutics. 7(2)
Constitutively activated signal transducer and activator of transcription-3 (STAT3) in tumor and dendritic cells (DCs) plays a critical role in tumor-induced immunosuppression. This is considered a major challenge in effective immunotherapy of cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e1cb3d636b269da115a3bfe423a83a
https://pubmed.ncbi.nlm.nih.gov/20030320
https://pubmed.ncbi.nlm.nih.gov/20030320