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pro vyhledávání: '"Samar Elsebaey"'
Publikováno v:
Recent Patents on Anti-Cancer Drug Discovery. 18
Background: Solid tumors such as colon cancer are characterized by rapid and sustained cell proliferation, which ultimately results in hypoxia, induction of hypoxia-inducible factor-1α (HIF-1α), and activation of glycolysis to promote tumor surviva
Publikováno v:
Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 154
Hypoxic microenvironment of colon cancer is associated with HIF-1α upregulation. HIF-1α response elements are responsible for autophagy induction that promotes tumor proliferation. Moreover, HIF-1α induces tumor cell proliferation via maintaining