Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Samar Abdulkhalek"'
Publikováno v:
Cells, Vol 12, Iss 9, p 1332 (2023)
We discovered a novel therapeutic target critical for SARS-CoV-2, cellular infectivity and the induction of the cytokine release syndrome. Here, we show that the mammalian enzyme neuraminidase-1 (Neu-1) is part of a highly conserved signaling platfor
Externí odkaz:
https://doaj.org/article/ec6a093080f4491495b262426dc6a870
Autor:
Samar Abdulkhalek, Olivia D Geen, Lacey Brodhagen, Fiona Haxho, Farah Alghamdi, Stephanie Allison, Duncan J Simmons, Leah K O'Shea, Ronald J Neufeld, Myron R Szewczuk
Publikováno v:
Clinical and Translational Medicine, Vol 3, Iss 1, Pp n/a-n/a (2014)
Abstract Background Snail, a transcriptional factor and repressor of E‐cadherin is well known for its role in cellular invasion. It can regulate epithelial to mesenchymal transition (EMT) during embryonic development and in epithelial cells. Snail
Externí odkaz:
https://doaj.org/article/38c8dfa6ede8475294541e744ba197bc
Publikováno v:
Journal of Hunan University Natural Sciences. 49:333-343
The article aims to assess the stochastic model's control variant and study the effect of time on the epidemic's behavior. A single population must have strong immunity as it recovers from the epidemic. Lower the infected and susceptible individuals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16f3f92f4786d50b057ffb61c1fcf6bc
https://doi.org/10.55463/issn.1674-2974.49.4.35
https://doi.org/10.55463/issn.1674-2974.49.4.35
Autor:
Sunil Rupee, Samar Abdulkhalek, Khemraj Rupee, Frank Christopher Howarth, Manal M. A. Smail, Jaipaul Singh, Carlin Hanoman, Farah Ahmed Sleiman, Keshore R Bidasee, Abla Mohammed Ismail
More than 450 million people worldwide have diabetes mellitus (DM), a metabolic disorder characterized by an increase in blood glucose level (hyperglycemia) that arises from insufficient insulin secretion or resistance to insulin’s action. More tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62bf2216b7c20dc5f4058aa468ae3d46
https://doi.org/10.5772/intechopen.93729
https://doi.org/10.5772/intechopen.93729
Autor:
Manoj Veleeparambil, Samar Abdulkhalek, Saurabh Chattopadhyay, Darshana Poddar, Volker Fensterl, Sudip K Bandyopadhyay, Ganes C. Sen
Publikováno v:
EMBO reports. 16:1535-1547
Mammalian Toll-like receptors (TLR) recognize microbial products and elicit transient immune responses that protect the infected host from disease. TLR4--which signals from both plasma and endosomal membranes--is activated by bacterial lipopolysaccha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::672d85991ba660a506457a74d86753bf
https://doi.org/10.15252/embr.201540337
https://doi.org/10.15252/embr.201540337
Autor:
Darshana Poddar, Patricia M Kessler, Samar Abdulkhalek, Ganes C. Sen, Michifumi Yamashita, Saurabh Chattopadhyay, Manoj Veleeparambil
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 200(8)
Mammalian TLRs recognize microbial infection or cell death–associated danger signals and trigger the appropriate cellular response. These responses determine the strength and the outcome of the host–microbe interaction. TLRs are transmembrane pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1651276e94095d7656720c28be1edf2c
https://pubmed.ncbi.nlm.nih.gov/29531172
https://pubmed.ncbi.nlm.nih.gov/29531172
Autor:
Timothy S.W. Cheng, Olivia Geen, Alanna Gilmour, Preethi Jayanth, Myron R. Szewczuk, Farah Alghamdi, Leah K O'Shea, Samar Abdulkhalek, Luis A. Arvizu
Publikováno v:
Cellular Signalling. 25(12):2587-2603
Epidermal growth factor (EGF)-induced EGFR tyrosine kinase receptor activation in cancer cell survival responses has become a strategic molecular-targeting clinical therapeutic intent, but the failures of these targeted approaches in the clinical set
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb694a8d6887977fe2a00928973461d3
Autor:
Myron R. Szewczuk, Samar Abdulkhalek
Publikováno v:
Cellular Signalling. 25:2093-2105
The precise mechanism(s) by which intracellular TOLL-like receptors (TLRs) become activated by their ligands remains unclear. Here, we report a molecular organizational G-protein coupled receptor (GPCR) signaling platform to potentiate a novel mammal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dfc735e1051b95410ee10d7e38ab714
https://doi.org/10.1016/j.cellsig.2013.06.010
https://doi.org/10.1016/j.cellsig.2013.06.010
Autor:
Samar Abdulkhalek, Christina Guzzo, Schammim Ray Amith, Preethi Jayanth, Susan Franchuk, Rudi Beyaert, Katrina Gee, Trisha Finlay, Myron R. Szewczuk, Merry Guo, Alanna Gilmour
Publikováno v:
Journal of Biological Chemistry. 286:36532-36549
The signaling pathways of mammalian Toll-like receptors (TLRs) are well characterized, but the precise mechanism(s) by which TLRs are activated upon ligand binding remains poorly defined. Recently, we reported a novel membrane sialidase-controlling m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21beb78b55de9193c2bc86fcc4ae5bca
https://doi.org/10.1074/jbc.m111.237578
https://doi.org/10.1074/jbc.m111.237578
Autor:
Samar Abdulkhalek, Fiona Haxho, Myron R. Szewczuk, Lacey Brodhagen, Farah Alghamdi, Victoria El Kuta, Stephanie Allison, Ronald J. Neufeld
Publikováno v:
Breast Cancer : Targets and Therapy
Fiona Haxho,1 Stephanie Allison,2 Farah Alghamdi,1,3 Lacey Brodhagen,1 Victoria EL Kuta,1 Samar Abdulkhalek,1,4 Ronald J Neufeld,2 Myron R Szewczuk1 1Department of Biomedical and Molecular Sciences, 2Department of Chemical Engineering, Queen’s Univ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7776ba50edcd8079f3de4986652fa4a
https://pubmed.ncbi.nlm.nih.gov/25525387
https://pubmed.ncbi.nlm.nih.gov/25525387