Supplementary Data from Asporin Restricts Mesenchymal Stromal Cell Differentiation, Alters the Tumor Microenvironment, and Drives Metastatic Progression

Autor: Paula J. Hurley, Ben H. Park, W. Nathaniel Brennen, John T. Isaacs, Elana J. Fertig, Isla P. Garraway, Daniel L.J. Thorek, Ryan C. Riddle, Steven S. An, Elai Davicioni, Jessie Huang, Tamara Lotan, Michael C. Haffner, Debebe Theodros, Samantha Torquato, Valentina Kugler, Rebecca Miller, Hamda Khan, Brian W. Simons, Robert M. Hughes

Figure S1: Comparison of Aspn+/+ and Aspn-/- mice. Figure S2: Representative gating of murine MSCs. Figure S3: ASPN restricts MSC differentiation. Figure S4: ASPN expression in cancer cell lines. Figure S5: ASPN increases cancer cell migration. Figur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::482e176198dc913f813dd0303bc7e0ee
https://doi.org/10.1158/0008-5472.22421327.v1

A novel quantitative real-time PCR diagnostic assay for fecal and nasal swab detection of an otariid lungworm, Parafilaroides decorus

Autor: William D. Sandke, Kalani M. Williams, M.K. Fessler, Pádraig J. Duignan, Caroline D. Keroack, Clara R. Malekshahi, Steven A. Williams, R.A. Bloomfield, Samantha Torquato

Publikováno v: International Journal for Parasitology: Parasites and Wildlife, Vol 12, Iss, Pp 85-92 (2020)
International Journal for Parasitology: Parasites and Wildlife

Parafilaroides decorus, also known as sea lion lungworm, is a metastrongyloid nematode that infects otariid hosts, such as the charismatic California sea lion, Zalophus californianus. P. decorus causes bronchointerstitial pneumonia, respiratory distr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a16b336fdca496ed0370e81ee7e5f8
https://doi.org/10.1016/j.ijppaw.2020.04.012

Genetic Alterations Detected in Cell-Free DNA Are Associated With Enzalutamide and Abiraterone Resistance in Castration-Resistant Prostate Cancer

Autor: Paula J. Hurley, Ben Ho Park, Bruce Kressel, John L. Silberstein, Daniel Shinn, Ian Waters, Brian W. Simons, Alexa Goldstein, Mario A. Eisenberger, Robert M. Hughes, Aparna Pallavajjala, Taylor Groginski, Patricia Valda Toro, Bruce J. Trock, Emmanuel S. Antonarakis, Mary Nakazawa, Zhaoyong Feng, Justin Lee, David Chu, Channing J. Paller, Hamda Khan, Samuel R. Denmeade, Michael A. Carducci, Samantha Torquato

Publikováno v: JCO precision oncology

PURPOSE Androgen receptor ( AR) gene alterations, including ligand-binding domain mutations and copy number (CN) gain, have yet to be fully established as predictive markers of resistance to enzalutamide and abiraterone in men with metastatic castrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c3b383f0b9123ea3148f32e3f64bc9
http://europepmc.org/articles/PMC6532665

Detection fidelity of AR mutations in plasma derived cell-free DNA

Autor: John L. Silberstein, Paula J. Hurley, Minsoo Kim, Ian Waters, Daniel Shinn, Bruce Kressel, Aparna Pallavajjala, Justin Lee, Karen Cravero, Alexa Goldstein, Mario A. Eisenberger, Samuel R. Denmeade, Emmanuel S. Antonarakis, Michael A. Carducci, Mary Nakazawa, Patricia Valda Toro, Samantha Torquato, Bruce J. Trock, Rory L. Cochran, Ben Ho Park, Channing J. Paller, Robert M. Hughes, David Chu

Publikováno v: Oncotarget

// Alexa Goldstein 1, 2, 3 , Patricia Valda Toro 1, 2, 3 , Justin Lee 2, 3 , John L. Silberstein 1, 3 , Mary Nakazawa 1, 3 , Ian Waters 2, 3 , Karen Cravero 2, 3 , David Chu 2, 3 , Rory L. Cochran 2, 3 , Minsoo Kim 2, 3 , Daniel Shinn 2, 3 , Samantha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a0d8d826b8d71d5cbdc64c304b8803
https://pubmed.ncbi.nlm.nih.gov/28152506

Abstract 18587: Downregulation of Pulmonary Artery Endothelial Catechol-o-methyltransferase Activity by Aldosterone Increases Norepinephrine Levels in Pulmonary Arterial Hypertension

Autor: Kiyotake Ishikawa, Bradley A. Maron, Samantha Torquato, Roger J. Hajjar, Jane A. Leopold, Jaume Aguerro, Joseph Loscalzo

Publikováno v: Circulation. 130

Elevated levels of norepinephrine (NE) occur in pulmonary arterial hypertension (PAH) and are determined, in part, by the activity of catechol- O -methyltransferase (COMT). COMT degrades catecholamines, is negatively regulated by calcium, and is expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8959156c13292cc89f66b5ed3855c65a
https://doi.org/10.1161/circ.130.suppl_2.18587