Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Samantha Schrecke"'
Autor:
Samantha Schrecke, Kevin McManus, Cassandra Moshfegh, Jessica Stone, Thuy-Uyen Nguyen, Gustavo Rivas, Ismaeel Muhamed, Daniel A. J. Mitchell
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Cell and gene therapy (CGT) is a field of therapeutic medicine that aims to treat, prevent, and cure diseases using engineered cells (stem cells, immune cells, and differentiated adult or fetal cells), vectors [Adeno Associated Virus (AAV), Adeno Vir
Externí odkaz:
https://doaj.org/article/9d1bb476a2d1478a914c1f3c78361416
Autor:
Lauren Stover, Hanieh Bahramimoghaddam, Lie Wang, Samantha Schrecke, Gaya P. Yadav, Ming Zhou, Arthur Laganowsky
Publikováno v:
Journal of Structural Biology: X, Vol 9, Iss , Pp 100097- (2024)
Aquaporin Z (AqpZ), a bacterial water channel, forms a tetrameric complex and, like many other membrane proteins, activity is regulated by lipids. Various methods have been developed to facilitate structure determination of membrane proteins, such as
Externí odkaz:
https://doaj.org/article/1d7cf849e1b042a19cb46fe7034bb63c
Autor:
Yun Zhu, Bo-Ji Peng, Smriti Kumar, Lauren Stover, Jing-Yuan Chang, Jixing Lyu, Tianqi Zhang, Samantha Schrecke, Djavdat Azizov, David H. Russell, Lei Fang, Arthur Laganowsky
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
Abstract Native mass spectrometry (MS) is a powerful technique for interrogating membrane protein complexes and their interactions with other molecules. A key aspect of the technique is the ability to preserve native-like structures and noncovalent i
Externí odkaz:
https://doaj.org/article/94436c1d1e2341babb198910d8bb6e06
Autor:
Jixing Lyu, Chang Liu, Tianqi Zhang, Samantha Schrecke, Nicklaus P. Elam, Charles Packianathan, Georg K. A. Hochberg, David Russell, Minglei Zhao, Arthur Laganowsky
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The bacterial ABC transporter MsbA is essential for lipopolysaccharide biogenesis. Here, the authors apply native mass spectrometry, X-ray crystallography, cryo-EM and biochemical approaches to characterize the structural basis and functional roles o
Externí odkaz:
https://doaj.org/article/5e9d0f15449143aebe7c810597dff7e1
Autor:
Yun Zhu, Samantha Schrecke, Shuli Tang, Melanie T. Odenkirk, Thomas Walker, Lauren Stover, Jixing Lyu, Tianqi Zhang, David Russell, Erin S. Baker, Xin Yan, Arthur Laganowsky
Publikováno v:
J Am Chem Soc
TRAAK and TREK2 are two-pore domain K(+) (K2P) channels and modulated by diverse factors including temperature, membrane stretching, and lipids, such as phosphatidic acid. In addition, copper and zinc, both of which are essential for life, are known
Autor:
Arthur Laganowsky, David H. Russell, Minglei Zhao, Jacob W. McCabe, Mariah Bartz, Samantha Schrecke, Charles Packianathan, Yun Zhu, Ming Zhou
Publikováno v:
Nature chemical biology
TRAAK is an ion channel from the two-pore domain potassium (K2P) channel family with roles in maintaining the resting membrane potential and fast action potential conduction. Regulated by a wide range of physical and chemical stimuli, the affinity an
Autor:
Smriti Kumar, Samantha Schrecke, David H. Russell, Jacob W. McCabe, Arthur Laganowsky, Tianqi Zhang, Pei Qiao, Jixing Lyu, Thomas E. Walker, Yun Zhu, David E. Clemmer
Publikováno v:
J Phys Chem Lett
Understanding the molecular driving forces that underlie membrane protein-lipid interactions requires the characterization of their binding thermodynamics. Here, we employ native mass spectrometry in conjunction with a variable temperature apparatus
Autor:
Amanda Benavides, Tianqi Zhang, Pei Qiao, Samantha Schrecke, Jixing Lyu, Arthur Laganowsky, Yun Zhu
Publikováno v:
Biochemistry
The G-protein gated inwardly rectifying potassium channel 4 (Kir3.4) subunit forms functional tetramers. Previous studies have established that phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) is required for Kir3.4 function. However, the binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3793bd9415001921785f1c689a33ee04
https://europepmc.org/articles/PMC9569133/
https://europepmc.org/articles/PMC9569133/
Autor:
Samantha Schrecke, David H. Russell, Zahra Moghadamchargari, Arthur Laganowsky, Minglei Zhao, Chang Liu, Charles Packianathan, Mehdi Shirzadeh
Publikováno v:
Proc Natl Acad Sci U S A
Ras is regulated by a specific guanine nucleotide exchange factor Son of Sevenless (SOS), which facilitates the exchange of inactive, GDP-bound Ras with GTP. The catalytic activity of SOS is also allosterically modulated by an active Ras (Ras–GTP).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41fbcd47635cfd027efcbbb773d0935c
https://europepmc.org/articles/PMC8000204/
https://europepmc.org/articles/PMC8000204/
Autor:
Yang Liu, David H. Russell, Arthur Laganowsky, Samantha Schrecke, Jixing Lyu, Jacob W. McCabe, Lei Fang
Publikováno v:
Anal Chem
There is growing interest in the characterization of protein complexes and their interactions with ligands using native ion mobility mass spectrometry. A particular challenge, especially for membrane proteins, is preserving noncovalent interactions a