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Publikováno v:
OALib. :1-5
Autor:
Ngoc Chau, Phillip J. Robinson, Wiebke Stahlschmidt, Jennifer R. Baker, Adam McCluskey, Ainslie Whiting, Volker Haucke, Mark J. Robertson, Lisa von Kleist, Marc Nazaré, André Horatscheck, Samantha Sauer
Publikováno v:
Organic & Biomolecular Chemistry. 14:11266-11278
The development of a (Z)-5-((6,8-dichloro-4-oxo-4H-chromen-3-yl)methylene)-2-thioxothiazolidin-4-one (2), rhodanine-based lead that led to the Pitstop® 2 family of clathrin inhibitors is described herein. Head group substitution and bioisosteric rep