Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Samantha Rutherford"'
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Pharmaceutical manufacturing is reliant upon bioprocessing approaches to generate the range of therapeutic products that are available today. The high cost of production, susceptibility to process failure, and requirement to achieve consistent, high-
Externí odkaz:
https://doaj.org/article/556b9f91ead44dcd9f0349d187fa84c1
Autor:
Annabel Hosie, Maria Firdaus, Jan Clarkson, Ekta Gupta, Lynn Laidlaw, Thomas Lamont, Margaret Mooney, Gillian Nevin, Craig Ramsay, Samantha Rutherford, Ana Margarida Sardo, Irene Soulsby, Derek Richards, Douglas Stirling, Michele West, Beatriz Goulao
Publikováno v:
Health Expectations, Vol 27, Iss 1, Pp n/a-n/a (2024)
Abstract Background Citizen science is a way to democratise science by involving groups of citizens in the research process. Clinical guidelines are used to improve practice, but their implementation can be limited. Involving patients and the public
Externí odkaz:
https://doaj.org/article/224fc210f58949ef927607fe69aa17e1
Publikováno v:
Clinical Drug Investigation. 31:101-111
Background: Sugammadex is a γ-cyclodextrin that binds with high affinity to the neuromuscular blocking agents (NMBAs) rocuronium (bromide) and vecuronium (bromide) by encapsulation. Cyclodextrins are known to form inclusion complexes with other comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ea249ef0f3b49654080b37c5a49ffb
https://doi.org/10.1007/bf03256937
https://doi.org/10.1007/bf03256937
Publikováno v:
Current Opinion in Pharmacology. 7:298-302
Traditionally, reversal of neuromuscular blockade during anaesthesia was achieved by increasing the acetylcholine concentration in the neuromuscular junction using acetylcholinesterase inhibitors. However, this is ineffective against profound blockad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4faed25639d1a57acf59111e0aee4502
https://doi.org/10.1016/j.coph.2006.11.009
https://doi.org/10.1016/j.coph.2006.11.009
Publikováno v:
Magnetic resonance in chemistry : MRC. 43(6)
The usefulness of bovine serum albumin (BSA) as a model protein for testing NMR methods for the study of protein-ligand interactions is discussed. Isothermal titration calorimetry established the binding affinity and stoichiometry of the specific bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4c2fc4f002513416005307433d76126
https://pubmed.ncbi.nlm.nih.gov/15816062
https://pubmed.ncbi.nlm.nih.gov/15816062
Publikováno v:
Organicbiomolecular chemistry. 1(23)
A collection of small molecules (MW350 Da) was screened for binding to human factor Xa using saturation transfer difference NMR spectroscopy to detect binding. The NMR screening experiments identified four hits. Binding isotherms constructed from NMR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a83adc9e6533591f70401740ad8561b
https://pubmed.ncbi.nlm.nih.gov/14685325
https://pubmed.ncbi.nlm.nih.gov/14685325
Autor:
Samantha Rutherford, Gary J. Tarver, Ming Qiang Zhang, Anton Bom, Kirsteen Buchanan, Grove Simon James Anthony, Andrew Cooke
Publikováno v:
Bioorganicmedicinal chemistry. 10(6)
A series of secondary face modified cyclodextrins (CDs) were synthesised with the aim of constructing host molecules capable of forming host–guest complexes with neuromuscular blockers, especially with rocuronium bromide. Perfacial 2- O -substituti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::affdee9e0795c78db06cadb6d1dd61e9
https://pubmed.ncbi.nlm.nih.gov/11937340
https://pubmed.ncbi.nlm.nih.gov/11937340