Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Samantha R Oakes"'
Autor:
Catherine L Piggin, Daniel L Roden, Andrew M K Law, Mark P Molloy, Christoph Krisp, Alexander Swarbrick, Matthew J Naylor, Maria Kalyuga, Warren Kaplan, Samantha R Oakes, David Gallego-Ortega, Susan J Clark, Jason S Carroll, Nenad Bartonicek, Christopher J Ormandy
Publikováno v:
PLoS Genetics, Vol 16, Iss 1, p e1008531 (2020)
Acquired resistance to endocrine therapy is responsible for half of the therapeutic failures in the treatment of breast cancer. Recent findings have implicated increased expression of the ETS transcription factor ELF5 as a potential modulator of estr
Externí odkaz:
https://doaj.org/article/f5de2fac668846768ca5f83785f674e7
Autor:
Samantha R Oakes, David Gallego-Ortega, Prudence M Stanford, Simon Junankar, Wendy Wing Yee Au, Zoya Kikhtyak, Anita von Korff, Claudio M Sergio, Andrew M K Law, Lesley E Castillo, Stephanie L Allerdice, Adelaide I J Young, Catherine Piggin, Belinda Whittle, Edward Bertram, Matthew J Naylor, Daniel L Roden, Jesse Donovan, Alexei Korennykh, Christopher C Goodnow, Moira K O'Bryan, Christopher J Ormandy
Publikováno v:
PLoS Genetics, Vol 13, Iss 11, p e1007072 (2017)
We identified a non-synonymous mutation in Oas2 (I405N), a sensor of viral double-stranded RNA, from an ENU-mutagenesis screen designed to discover new genes involved in mammary development. The mutation caused post-partum failure of lactation in hea
Externí odkaz:
https://doaj.org/article/76d21e2f20924475a4c47cb697a95a92
Autor:
David Gallego-Ortega, Anita Ledger, Daniel L Roden, Andrew M K Law, Astrid Magenau, Zoya Kikhtyak, Christina Cho, Stephanie L Allerdice, Heather J Lee, Fatima Valdes-Mora, David Herrmann, Robert Salomon, Adelaide I J Young, Brian Y Lee, C Marcelo Sergio, Warren Kaplan, Catherine Piggin, James R W Conway, Brian Rabinovich, Ewan K A Millar, Samantha R Oakes, Tatyana Chtanova, Alexander Swarbrick, Matthew J Naylor, Sandra O'Toole, Andrew R Green, Paul Timpson, Julia M W Gee, Ian O Ellis, Susan J Clark, Christopher J Ormandy
Publikováno v:
PLoS Biology, Vol 13, Iss 12, p e1002330 (2015)
During pregnancy, the ETS transcription factor ELF5 establishes the milk-secreting alveolar cell lineage by driving a cell fate decision of the mammary luminal progenitor cell. In breast cancer, ELF5 is a key transcriptional determinant of tumor subt
Externí odkaz:
https://doaj.org/article/eb537bc34b10404fbde06ea888ba833f
Autor:
Maria Kalyuga, David Gallego-Ortega, Heather J Lee, Daniel L Roden, Mark J Cowley, C Elizabeth Caldon, Andrew Stone, Stephanie L Allerdice, Fatima Valdes-Mora, Rosalind Launchbury, Aaron L Statham, Nicola Armstrong, M Chehani Alles, Adelaide Young, Andrea Egger, Wendy Au, Catherine L Piggin, Cara J Evans, Anita Ledger, Tilman Brummer, Samantha R Oakes, Warren Kaplan, Julia M W Gee, Robert I Nicholson, Robert L Sutherland, Alexander Swarbrick, Matthew J Naylor, Susan J Clark, Jason S Carroll, Christopher J Ormandy
Publikováno v:
PLoS Biology, Vol 10, Iss 12, p e1001461 (2012)
We have previously shown that during pregnancy the E-twenty-six (ETS) transcription factor ELF5 directs the differentiation of mammary progenitor cells toward the estrogen receptor (ER)-negative and milk producing cell lineage, raising the possibilit
Externí odkaz:
https://doaj.org/article/7e94d3be63174fc88be2581b9f7d3521
Autor:
Nathan W. Zammit, Joseph McDowell, Joanna Warren, Walter Muskovic, Joanne Gamble, Yan-Chuan Shi, Dominik Kaczorowski, Chia-Ling Chan, Joseph Powell, Chris Ormandy, David Brown, Samantha R. Oakes, Shane T. Grey
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Women with autoimmune and inflammatory aetiologies can exhibit reduced fecundity. TNFAIP3 is a master negative regulator of inflammation, and has been linked to many inflammatory conditions by genome wide associations studies, however its role in fer
Externí odkaz:
https://doaj.org/article/a3dbda4377db4fd2b3439ec0ab65c36f
Autor:
Fatima Valdes-Mora, Kristina Handler, Andrew M. K. Law, Robert Salomon, Samantha R. Oakes, Christopher J. Ormandy, David Gallego-Ortega
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Cancer is a heterogeneous and complex disease. Tumors are formed by cancer cells and a myriad of non-cancerous cell types that together with the extracellular matrix form the tumor microenvironment. These cancer-associated cells and components contri
Externí odkaz:
https://doaj.org/article/27903686e0c942289f8c9dfe1b98c669
Autor:
Samantha R. Oakes, John Simes, Frank Lin, Maya Kansara, Subotheni Thavaneswaran, John P. Grady, Jayesh Desai, Chee Khoon Lee, Mandy L. Ballinger, David Thomas
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-10 (2021)
NPJ Precision Oncology
NPJ Precision Oncology
While several resources exist that interpret therapeutic significance of genomic alterations in cancer, many regional real-world issues limit access to drugs. There is a need for a pragmatic, evidence-based, context-adapted tool to guide clinical man
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6f6430a6a07ffdb25a8c7df0413b71
https://doaj.org/article/6a749ceadf654e848f7ee68f6d873817
https://doaj.org/article/6a749ceadf654e848f7ee68f6d873817
Autor:
Anthony M. Joshua, Adam Sharp, Bruce Montgomery, Zvi Shalev, Samantha R. Oakes, Amina Zoubeidi, Bradly G. Wouters, David Uehling, Marianne Koritzinsky, Richard Marcellus, Stefano Marastoni, Sujeeve Jeganathan, Ines Figueiredo, Bora Gurel, Haiyang Guo, Aleksandra Pesic, Antje Neeb, Amanda Mawson, Housheng Hansen He, Martin E. Gleave, Johann S. de Bono, Joan Sweet, Yi Liang
Publikováno v:
Clinical Cancer Research. 27:2340-2351
Purpose: Although enzalutamide (ENZ) has been widely used to treat de novo or castration-resistant metastatic prostate cancer, resistance develops and disease progression is ultimately inevitable. There are currently no approved targeted drugs to spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c22ff4918503fd60eba6cd6444121eb3
https://doi.org/10.1158/1078-0432.ccr-20-3260
https://doi.org/10.1158/1078-0432.ccr-20-3260
Autor:
Samantha R. Oakes, Andrew M. K. Law, David Gallego Ortega, Christopher C. Goodnow, Moira K O'Bryan, Christopher J. Ormandy, Amanda Mawson, Lesley Castillo, Wing-Hong Jonathan Ho, Etienne Masle-Farquhar
BackgroundThe interferon response can influence the primary and metastatic activity of breast cancers and can interact with checkpoint immunotherapy to modulate its effects. UsingN-ethyl-N-nitrosourea mutagenesis, we found a mouse with an activating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df9a4560fe9a8076ede4fbd5485444ac
https://hdl.handle.net/10453/166464
https://hdl.handle.net/10453/166464
Autor:
Adelaide I. J. Young, Paul Timpson, Amanda Mawson, Ashleigh Parkin, Danielle Nessem, David Gallego-Ortega, Pia Schafranek, Samantha R. Oakes, Catherine E Caldon, Angela Steinmann, Andrew M. K. Law, Angela Chou, Niantao Deng, Christopher J. Ormandy, Morghan C. Lucas, Lesley Castillo, Marina Pajic, Kendelle J. Murphy, Amber L. Johns
Publikováno v:
Oncogene
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies. It is phenotypically heterogeneous with a highly unstable genome and provides few common therapeutic targets. We found that MCL1, Cofilin1 (CFL1) and SRC mRNA were hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9bbd8992ce18e36adc02f31e5d4a292
http://europepmc.org/articles/PMC7033042
http://europepmc.org/articles/PMC7033042