Kv2.1 channels play opposing roles in regulating membrane potential, Ca 2+ channel function, and myogenic tone in arterial smooth muscle

Autor: Laura Guarina, Samantha O’Dwyer, L. Fernando Santana, James S. Trimmer, Collin Matsumoto, Barbara Rosati, Nicholas R. Klug, David McKinnon, Sendoa Tajada, Stephanie Palacio

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 7
Proceedings of the National Academy of Sciences of the United States of America

Significance Our data challenge the generally accepted view that Kv2.1 proteins regulate arterial smooth muscle function by regulating their membrane potential. Rather, we discovered that Kv2.1 plays both conductive and structural roles with opposing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d055ecc155ca71fbda75d38ea3d2ea
https://doi.org/10.1073/pnas.1917879117

Maladaptive response of arterial myocytes to chronic exposure to Ca 2+ channel blockers

Autor: Luis Fernando Santana, Samantha O’Dwyer, Manuel F. Navedo

Publikováno v: Proc Natl Acad Sci U S A

> “The tragedies in life are largely arterial.” > > – Sir William Osler, 1908 (1) Hypertension is a debilitating cardiovascular disease characterized by the narrowing of arteries and arterioles which increases resistance to blood flow. This dec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bee6b48cb25459b3fc65ac0243355f1b
https://doi.org/10.1073/pnas.2011909117

BIN1 clusters Ca V 1.2 channels in vascular smooth muscle

Autor: Claudia M. Moreno, Nicholas R. Klug, Luis Fernando Santana, Samantha O’Dwyer

Publikováno v: The FASEB Journal. 33

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::189d63f5eb44aea9cf6c5318276f6318
https://doi.org/10.1096/fasebj.2019.33.1_supplement.827.2