Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Samantha Mota"'
Autor:
Thomas Bourquard, Kwanghyuk Lee, Ismael Al-Ramahi, Minh Pham, Dillon Shapiro, Yashwanth Lagisetty, Shirin Soleimani, Samantha Mota, Kevin Wilhelm, Maryam Samieinasab, Young Won Kim, Eunna Huh, Jennifer Asmussen, Panagiotis Katsonis, Juan Botas, Olivier Lichtarge
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The incidence of Alzheimer’s Disease in females is almost double that of males. To search for sex-specific gene associations, we build a machine learning approach focused on functionally impactful coding variants. This method can detect di
Externí odkaz:
https://doaj.org/article/5fd507b11a1941148399c2ae7ff75fb9
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 3, p 831 (2020)
The goal of this review was to seek a better understanding of the function and differential expression of circadian clock genes during the reproductive process. Through a discussion of how the circadian clock is involved in these steps, the identific
Externí odkaz:
https://doaj.org/article/7a576ea971f348588b8f3d4a41278dd8
Autor:
Xiaoyue Pan, Cyrus Mowdawalla, Samantha Mota, M. Mahmood Hussain, Jeffrey Pessin, Volker Vallon
Publikováno v:
Physiology. 38
Background & Aims: The nuclear receptor subfamily 1, group D, member 1 (Nr1d1, also called Rev-erbα) is highly expressed in the kidney, and its transcriptional activity is increased by the clock gene Bmal1 (ARNTL or MOP3). Here we studied the roles
Autor:
Baylee J. O'Brien, Erika Y. Faraoni, Lincoln N. Strickland, Zhibo Ma, Victoria Mota, Samantha Mota, Xuebo Chen, Tingting Mills, Holger K. Eltzschig, Kathleen E. DelGiorno, Jennifer M. Bailey‐Lundberg
Publikováno v:
The FASEB Journal. 37
Pancreatitis is currently the leading cause of gastrointestinal hospitalizations in the US. This condition occurs in response to abdominal injury, gallstones, chronic alcohol consumption or, less frequently, the cause remains idiopathic. CD73 is a ce
Autor:
Yashwanth Lagisetty, Thomas Bourquard, Ismael Al-Ramahi, Carl Grant Mangleburg, Samantha Mota, Shirin Soleimani, Joshua M. Shulman, Juan Botas, Kwanghyuk Lee, Olivier Lichtarge
Publikováno v:
Cell genomics. 2(9)
Most disease-gene association methods do not account for gene-gene interactions, even though these play a crucial role in complex, polygenic diseases like Alzheimer's disease (AD). To discover new genes whose interactions may contribute to pathology,
Autor:
Baylee J. O’Brien, Erika Y. Faraoni, Lincoln N. Strickland, Zhibo Ma, Victoria Mota, Samantha Mota, Xuebo Chen, Tingting Mills, Holger K. Eltzschig, Kathleen E. DelGiorno, Jennifer M. Bailey-Lundberg
Background and AimsPancreatitis is currently the leading cause of gastrointestinal hospitalizations in the US. This condition occurs in response to abdominal injury, gallstones, chronic alcohol consumption or, less frequently, the cause remains idiop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c83f0bfc2546cc4f7aef69dea8965f43
https://doi.org/10.1101/2022.09.17.508367
https://doi.org/10.1101/2022.09.17.508367
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42
Macrophages play a critical role in atherosclerosis. We have previously shown that Clock mutant and global or liver-specific Bmal1 deficient mice show enhanced atherosclerosis. Yet, the role of macrophage Bmal1 in cholesterol transport and atheroscle
Autor:
Juan Botas, Ismael Al-Ramahi, Samantha Mota, Young Won Kim, Shirin Soleimani, Daniel M Konecki, Olivier Lichtarge, Stephen J. Wilson, Amanda Koire
Publikováno v:
Alzheimer's & Dementia
The strongest genetic risk factor for idiopathic late‐onset Alzheimer's disease (LOAD) is apolipoprotein E (APOE) ɛ4, while the APOE ɛ2 allele is protective. However, there are paradoxical APOE ɛ4 carriers who remain disease‐free and APOE ɛ2
Autor:
Huda Y. Zoghbi, Juan Botas, Ismael Al-Ramahi, Sih Rong Wu, Samantha Mota, Carolyn J. Adamski, Hari Krishna Yalamanchili, Laura A. Lavery, Smruti Rath, Harry T. Orr, Youjin Jang, Shirin Soleimani, Zhandong Liu, Vitaliy V. Bondar, Maxime W.C. Rousseaux, Won Seok Lee, Wonho Kim, Ying Wooi Wan, Ambika Tewari, Eric B. Rutledge
Publikováno v:
EMBO J
A critical question in neurodegeneration is why the accumulation of disease-driving proteins causes selective neuronal loss despite their brain-wide expression. In Spinocerebellar ataxia type 1 (SCA1), accumulation of polyglutamine-expanded Ataxin-1
Publikováno v:
Adv Exp Med Biol
Advances in Experimental Medicine and Biology ISBN: 9789811560811
Advances in Experimental Medicine and Biology ISBN: 9789811560811
The basic helix-loop-helix-PAS transcription factor (CLOCK, Circadian locomotor output cycles protein kaput) was discovered in 1994 as a circadian clock. Soon after its discovery, the circadian clock, Aryl hydrocarbon receptor nuclear translocator-li