Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Samantha Manimala"'
Autor:
Anne G. Savitt, Samantha Manimala, Tiara White, Marina Fandaros, Wei Yin, Huiquan Duan, Xin Xu, Brian V. Geisbrecht, David A. Rubenstein, Allen P. Kaplan, Ellinor I. Peerschke, Berhane Ghebrehiwet
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Infection with SARS-CoV-2 triggers the simultaneous activation of innate inflammatory pathways including the complement system and the kallikrein-kinin system (KKS) generating in the process potent vasoactive peptides that contribute to severe acute
Externí odkaz:
https://doaj.org/article/6770e2f74e8948b8a62d2b8fa28fe7c4
Autor:
Leonard Buckbinder, David J. St. Jean, Brendon Ladd, Trang Tieu, Philip Jonsson, Jacob Alltucker, Samantha Manimala, Weixue Wang, Angel Guzman-Perez, Darrin D. Stuart, Gregory Dowdell
Publikováno v:
Cancer Research. 83:P4-07
PI3Kα is highly mutated in cancer resulting in hyperactivation of lipid kinase activity and downstream AKT signaling. H1047 is the most common site of oncogenic mutation and occurs in ~14% of all breast cancers. Initial therapeutic benefit of target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f2a5e2df21cd5a0b3a1197e4686d037
https://doi.org/10.1158/1538-7445.sabcs22-p4-07-04
https://doi.org/10.1158/1538-7445.sabcs22-p4-07-04
Autor:
Leonard Buckbinder, David J. St. Jean, Trang Tieu, Weixue Wang, Gregory Kryukov, Philip Jonsson, Jacob Alltucker, Samantha Manimala, Brendon Ladd, Angel Guzman-Perez, Darrin Stuart
Publikováno v:
Cancer Research. 82:LB194-LB194
Oncogenic PIK3CA mutations are found in 14% of all cancers and most frequently occur at amino acids E542/E545 and H1047, involving the helical and kinase domains, respectively (Zhang 2017). Alpelisib is a PI3Kα isoform-selective, orthosteric kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea9734ae6b2d800a7c025ea3712aed00
https://doi.org/10.1158/1538-7445.am2022-lb194
https://doi.org/10.1158/1538-7445.am2022-lb194