Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Samantha M. Wightman"'
Autor:
Samantha M. Wightman, Tyler J. Alban, Xing Chen, Justin D. Lathia, Yuxin Wang, George R. Stark
Publikováno v:
Translational Oncology, Vol 14, Iss 11, Pp 101192- (2021)
An important factor correlated with poor survival in glioblastoma (GBM) is the aberrant and persistent activation of STAT3, a critical transcription factor that regulates multiple genes with key roles in cell survival, proliferation, resistance to ch
Externí odkaz:
https://doaj.org/article/2c3b6470cd93457e987e993caefb6814
Autor:
Rui Li, Yue Zhou, Xinxin Zhang, Lujia Yang, Jieyu Liu, Samantha M. Wightman, Ling Lv, Zhiqing Liu, Chang-Yun Wang, Chenyang Zhao
Publikováno v:
Marine Life Science & Technology. 5:94-101
The Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) regulates the expression of various critical mediators of cancer and is considered as one of the central communication nodes in cell growth and survival. Marine natural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::314413abb853de4efe7b677aae2c053b
https://doi.org/10.1007/s42995-022-00162-x
https://doi.org/10.1007/s42995-022-00162-x
Publikováno v:
Trends Cancer
Acute exposure of cancer cells to high concentrations of type I interferon (IFN-I) drives growth arrest and apoptosis, whereas chronic exposure to low concentrations provides important prosurvival advantages. Tyrosine-phosphorylated IFN-stimulated ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c449259e718a7fa344f3c3dfc45df1c
https://europepmc.org/articles/PMC9797472/
https://europepmc.org/articles/PMC9797472/
Autor:
Justin D. Lathia, Xing Chen, Samantha M. Wightman, Yuxin Wang, Tyler J. Alban, George R. Stark
Publikováno v:
Translational Oncology, Vol 14, Iss 11, Pp 101192-(2021)
Translational Oncology
Translational Oncology
Highlights • High STAT3 is correlated with poor prognosis in GBM. • Bazedoxifene targets IL-6-mediated sustained STAT3 activation. • STAT3 drives glioma stem cell maintenance, bazedoxifene targets this pathway. • Bazedoxifene crosses the BBB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::326b9743fbeb4ee2bb658cdcd3a133e1
http://www.sciencedirect.com/science/article/pii/S1936523321001844
http://www.sciencedirect.com/science/article/pii/S1936523321001844
Glioblastoma multiforme (GBM) is one of the most aggressive forms of brain tumor. With the current standard of care, the five year survival rate for GBM patients is less than 3%. An understanding of the molecular mechanisms promoting growth and survi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba04d94536c782c114c9b266615bbe37
https://europepmc.org/articles/PMC4638685/
https://europepmc.org/articles/PMC4638685/