Výsledky vyhledávání - "Samantha M. Sarett"

Hydrogel Microspheres for Spatiotemporally Controlled Delivery of Rna and Silencing Gene Expression within Scaffold-Free Tissue Engineered Constructs

Autor: Alexandra McMillan, Peilin Ge, Cong Truc Huynh, Craig L. Duvall, Melanie Chetverikova, Minh Khanh Nguyen, Kien Nguyen, Samantha M. Sarett, Eben Alsberg, David Grosh

Publikováno v: Acta Biomater

Delivery systems for controlled release of RNA interference (RNAi) molecules, including small interfering (siRNA) and microRNA (miRNA), have the potential to direct stem cell differentiation for regenerative musculoskeletal applications. To date, loc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f33d871feac71249fcb0bd817e4d78f
https://doi.org/10.2139/ssrn.3687962

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Selective mTORC2 Inhibitor Therapeutically Blocks Breast Cancer Cell Growth and Survival

Autor: Paula Gonzalez Ericsson, Meghan Morrison Joly, Rebecca S. Cook, Violeta Sanchez, Samantha M. Sarett, Linus Lee, Meredith A. Jackson, Kameron V. Kilchrist, Shan Wang, Taylor E. Kavanaugh, Donna J. Hicks, Thomas A. Werfel, Dana M. Brantley-Sieders, Craig L. Duvall, Somtochukwu C. Dimobi

Publikováno v: Cancer Research. 78:1845-1858

Small-molecule inhibitors of the mTORC2 kinase (torkinibs) have shown efficacy in early clinical trials. However, the torkinibs under study also inhibit the other mTOR-containing complex mTORC1. While mTORC1/mTORC2 combined inhibition may be benefici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::306e2642bf54c2fd3c1a807e184e20b1
https://doi.org/10.1158/0008-5472.can-17-2388

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Porcine Ischemic Wound-Healing Model for Preclinical Testing of Degradable Biomaterials

Autor: Craig L. Duvall, Samantha M. Sarett, Lillian B. Nanney, Nancy L. Cardwell, Jeffrey M. Davidson, Alonda C. Pollins, John R. Martin, Scott A. Guelcher, Prarthana Patil

Publikováno v: Tissue Engineering Part C: Methods. 23:754-762

Impaired wound healing that mimics chronic human skin pathologies is difficult to achieve in current animal models, hindering testing and development of new therapeutic biomaterials that promote wound healing. In this article, we describe a refinemen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f535d307acc00feda13412dd68f9006d
https://doi.org/10.1089/ten.tec.2017.0202

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Hydrophobic interactions between polymeric carrier and palmitic acid-conjugated siRNA improve PEGylated polyplex stability and enhance in vivo pharmacokinetics and tumor gene silencing

Autor: Craig L. Duvall, Madison E. Hattaway, Thomas A. Werfel, Samantha M. Sarett, Meredith A. Jackson, Irene Chandra, Taylor E. Kavanaugh, Todd D. Giorgio

Publikováno v: Biomaterials. 97:122-132

Formation of stable, long-circulating siRNA polyplexes is a significant challenge in translation of intravenously-delivered, polymeric RNAi cancer therapies. Here, we report that siRNA hydrophobization through conjugation to palmitic acid (siPA) impr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6781758c27ab8735a0fb3d0199653bc
https://doi.org/10.1016/j.biomaterials.2016.04.017

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Conjugation of palmitic acid improves potency and longevity of siRNA delivered via endosomolytic polymer nanoparticles

Autor: Samantha M. Sarett, Craig L. Duvall, Martina Miteva, Kameron V. Kilchrist

Publikováno v: Journal of Biomedical Materials Research Part A. 103:3107-3116

Clinical translation of siRNA therapeutics has been limited by the inability to effectively overcome the rigorous delivery barriers associated with intracellular-acting biologics. Here, to address both potency and longevity of siRNA gene silencing, p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e567e8503b40cf3c20512ac467753cde
https://doi.org/10.1002/jbm.a.35413

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Lipophilic siRNA targets albumin in situ and promotes bioavailability, tumor penetration, and carrier-free gene silencing

Autor: Craig L. Duvall, Thomas A. Werfel, Linus Lee, Samantha M. Sarett, Meredith A. Jackson, Kameron V. Kilchrist, Dana M. Brantley-Sieders

Clinical translation of therapies based on small interfering RNA (siRNA) is hampered by siRNA's comprehensively poor pharmacokinetic properties, which necessitate molecule modifications and complex delivery strategies. We sought an alternative approa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99ff074213566429ddf91cd0afd89c36
https://europepmc.org/articles/PMC5558996/

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Zwitterionic Nanocarrier Surface Chemistry Improves siRNA Tumor Delivery and Silencing Activity Relative to Polyethylene Glycol

Autor: Samantha M. Sarett, Kameron V. Kilchrist, Meredith A. Jackson, Taylor E. Kavanaugh, Todd D. Giorgio, Ayisha N. Jackson, Elizabeth J. Curvino, Craig L. Duvall, Fang Yu, Thomas A. Werfel, Mary D. Dockery

Although siRNA-based nanomedicines hold promise for cancer treatment, conventional siRNA–polymer complex (polyplex) nanocarrier systems have poor pharmacokinetics following intravenous delivery, hindering tumor accumulation. Here, we determined the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3989b7dcda3899b5aed7fca4ca92143
https://europepmc.org/articles/PMC5919184/

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