Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Samantha M. Morrissey"'
Autor:
Samantha M. Morrissey, Anne E. Geller, Xiaoling Hu, David Tieri, Chuanlin Ding, Christopher K. Klaes, Elizabeth A. Cooke, Matthew R. Woeste, Zachary C. Martin, Oscar Chen, Sarah E. Bush, Huang-ge Zhang, Rodrigo Cavallazzi, Sean P. Clifford, James Chen, Smita Ghare, Shirish S. Barve, Lu Cai, Maiying Kong, Eric C. Rouchka, Kenneth R. McLeish, Silvia M. Uriarte, Corey T. Watson, Jiapeng Huang, Jun Yan
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
SARS coronavirus 2 (SARS-CoV-2) is a novel viral pathogen that causes a clinical disease called coronavirus disease 2019 (COVID-19). Although most COVID-19 cases are asymptomatic or involve mild upper respiratory tract symptoms, a significant number
Externí odkaz:
https://doaj.org/article/cd228fc8771e4fcab54acb1172e0ffbe
Autor:
Samantha M. Morrissey, Jun Yan
Publikováno v:
Trends Cancer
The use of immune checkpoint therapies targeting programmed death-1 (PD-1) and its ligand (PD-L1) continue to show limited, durable success in clinical cases, despite widespread application. While some patients achieve complete responses and disease
Autor:
Samantha M. Morrissey
The formation of a pre-metastatic niche is a fundamental requirement for primary tumor metastasis. One of the defining characteristics of a pre-metastatic niche is infiltration of immunosuppressive macrophages. However, how these macrophages acquire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b22dc841f217125fba8fd706f52acf1e
https://doi.org/10.18297/etd/3495
https://doi.org/10.18297/etd/3495
Autor:
Eun Jung Kim, Becca V. Baby, Ronald C. Bruntz, Matthew S. Gentry, Lindsey R. Conroy, Mariana Barbosa de Souza Rizzo, Kelly M. McMasters, Jordan T. Noe, Anne E. Geller, Hayley C. Affronti, Beatriz E. Rendon, Lance A. Johnson, Ramon C. Sun, Brian F. Clem, Robert A. Mitchell, Kathryn E. Wellen, Samantha M. Morrissey, Lyndsay E.A. Young, Ashley Wise-Mitchell, Jun Yan, Eric R. Relich
Publikováno v:
Science Advances
Description
Macrophages use mitochondrial lactate metabolism for ACLY-dependent histone acetylation, immune suppression, and tumor progression.
Lactate accumulation is a hallmark of solid cancers and is linked to the immune suppressive phen
Macrophages use mitochondrial lactate metabolism for ACLY-dependent histone acetylation, immune suppression, and tumor progression.
Lactate accumulation is a hallmark of solid cancers and is linked to the immune suppressive phen
Autor:
Zachary C Martin, Shirish Barve, David Tieri, Maiying Kong, Elizabeth A Cooke, Huang-Ge Zhang, Silvia M. Uriarte, Xiaoling Hu, Rodrigo Cavallazzi, Christopher K. Klaes, Oscar Chen, Kenneth R. McLeish, Lu Cai, James Ming Chen, Smita Ghare, Corey T. Watson, Sarah E Bush, Chuanlin Ding, Jiapeng Huang, Eric C. Rouchka, Sean P. Clifford, Jun Yan, Matthew R. Woeste, Samantha M. Morrissey, Anne E. Geller
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
JCI Insight
JCI Insight
SARS coronavirus 2 (SARS-CoV-2) is a novel viral pathogen that causes a clinical disease called coronavirus disease 2019 (COVID-19). Although most COVID-19 cases are asymptomatic or involve mild upper respiratory tract symptoms, a significant number
Autor:
Xiaoling Hu, Chuanlin Ding, David Tieri, Huang-ge Zhange, Samantha M. Morrissey, Corey T. Watson, Maiying Kong, Sean P. Clifford, James Ming Chen, Jiapeng Huang, Anne E. Geller, Rodrigo Cavallazi, Elizabeth A Cooke, Jun Yan, Matthew R. Woeste
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel viral pathogen that causes a clinical disease called coronavirus disease 2019 (COVID-19). Approximately 20% of infected patients experience a severe manifestation of the disease,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::608a37aee5101203b0a35118ca04fd7d
https://doi.org/10.1101/2020.05.22.20106724
https://doi.org/10.1101/2020.05.22.20106724
Autor:
Samantha M. Morrissey, Fan Zhang, Chenghui Yang, Zheng Wang, Xiaoling Hu, Matthew Fox, Chuanlin Ding, Huangge Zhang, Haixun Guo, David Tieri, Maiying Kong, Corey Watson, Robert Mitchell, Jian Huang, Jun Yan
Publikováno v:
SSRN Electronic Journal.
Autor:
Fan Zhang, Huang-Ge Zhang, Haixun Guo, Kelly M. McMasters, Maiying Kong, Chuanlin Ding, Robert A. Mitchell, Jun Yan, Samantha M. Morrissey, David Tieri, Zhen Wang, Chenghui Yang, Fang Yuan, Matthew P. Fox, Jian Huang, Xiang Zhang, Corey T. Watson, Diego E. Montoya-Durango, Xiaoling Hu
Publikováno v:
Cell Metab
One of the defining characteristics of a pre-metastatic niche, a fundamental requirement for primary tumor metastasis, is infiltration of immunosuppressive macrophages. How these macrophages acquire their phenotype remains largely unexplored. Here, w
Autor:
Yu-ling Wei, Yueh-hsiu Chien, Feng Xue, Yihua Cai, Venkatakrishna R. Jala, Xuan Sun, Bodduluri Haribabu, Samantha M. Morrissey, Chris Fleming, Jian Huang, Jun Yan, Huang-Ge Zhang
Publikováno v:
Microbiome, Vol 5, Iss 1, Pp 1-15 (2017)
Microbiome
Microbiome
Background IL-17-producing γδT cells (γδT17) promote autoinflammatory diseases and cancers. Yet, γδT17 peripheral regulation has not been thoroughly explored especially in the context of microbiota-host interaction. The potent antigen-presentin
Autor:
Kathryn E. Wellen, Jordan T. Noe, Hayley C. Affronti, Ronald C. Bruntz, Beatriz E. Rendon, Brian F. Clem, Lyndsay E.A. Young, Ramon C. Sun, Robert A. Mitchell, Eun Jung Kim, Samantha M. Morrissey, Lindsey R. Conroy, Anne E. Geller, Jun Yan
Publikováno v:
Cancer Research. 80:PR01-PR01
Tumor-associated macrophages polarized to an M2 phenotype (M2-TAMs) promote neo-angiogenesis, tumor-stromal matrix remodeling, and immuno-evasion which, collectively, contribute to immunotherapeutic resistance and reduced cancer patient survival. The