Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Samantha M. Keller"'
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 12 (2018)
Exposure to adversity early in development alters brain and behavioral trajectories. Data continue to accumulate that epigenetic mechanisms are a mediating factor between early-life adversity and adult behavioral phenotypes. Previous work from our la
Externí odkaz:
https://doaj.org/article/df38ea8287814ce4aeaad79fe67aea2c
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Scientific Reports
The quality of parental care received during development profoundly influences an individual’s phenotype, including that of maternal behavior. We previously found that female rats with a history of maltreatment during infancy mistreat their own off
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9621c6dc9fab40bfa16273fa40175b
http://link.springer.com/article/10.1038/s41598-019-46539-4
http://link.springer.com/article/10.1038/s41598-019-46539-4
Publikováno v:
Dev Psychobiol
The effects of exposure to developmental stress often diverge for males and females. Using the scarcity-adversity model of low nesting resources outside the home cage, our lab has discovered sex differences in both behavioral and epigenetic consequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bcfbc021c71e80ab539675be5fe83f0
https://doi.org/10.1002/dev.21834
https://doi.org/10.1002/dev.21834
Autor:
Samantha M. Keller, Marisa Chamness, Dayan Knox, Thomas DePietro, Caroline Lawless, Nina P. David, Briana R. Stanfield, Jennifer M. Staib, Elizabeth K. Schneider
Publikováno v:
Behavioural Brain Research. 341:189-197
Neural circuits via which stress leads to disruptions in fear extinction is often explored in animal stress models. Using the single prolonged stress (SPS) model of post traumatic stress disorder and the immediate early gene (IEG) c-Fos as a measure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::badf8f113f12e4f59d32f23c69c99f89
https://doi.org/10.1016/j.bbr.2017.12.037
https://doi.org/10.1016/j.bbr.2017.12.037
Autor:
Thomas DePietro, Samantha M. Keller, Jennifer M. Staib, Dayan Knox, Nina P. David, Briana R. Stanfield
Publikováno v:
Learning & Memory. 23:689-698
Single prolonged stress (SPS) has been used to examine mechanisms via which stress exposure leads to post-traumatic stress disorder symptoms. SPS induces fear extinction retention deficits, but neural circuits critical for mediating these deficits ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8585d113087054a5062f8559fe2a66d5
https://doi.org/10.1101/lm.043141.116
https://doi.org/10.1101/lm.043141.116
Autor:
Dayan Knox, Samantha M. Keller
Publikováno v:
Hippocampus. 26:718-726
Previous research has shown that the ventral medial prefrontal cortex (vmPFC) and hippocampus (Hipp) are critical for extinction memory. Basal forebrain (BF) cholinergic input to the vmPFC and Hipp is critical for neural function in these substrates,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e7aecd2d32b783eff425a0423087a19
https://doi.org/10.1002/hipo.22553
https://doi.org/10.1002/hipo.22553
Publikováno v:
Behavioural Brain Research. 287:182-186
Using the single prolonged stress (SPS) animal model of post-traumatic stress disorder (PTSD), previous studies suggest that enhanced glucocorticoid receptor (GR) expression leads to cued fear extinction retention deficits. However, it is unknown how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fc995f2ae6933f3d2135b16fdbb6c79
https://doi.org/10.1016/j.bbr.2015.03.043
https://doi.org/10.1016/j.bbr.2015.03.043
Publikováno v:
Behavioural Brain Research. 286:29-32
Post traumatic stress disorder (PTSD) is a debilitating anxiety disorder resulting from traumatic stress exposure. Females are more likely to develop PTSD than males, but neurobiological mechanisms underlying female susceptibility are lacking. This c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19f6995a3c9163bd76bc03e508e607fe
https://doi.org/10.1016/j.bbr.2015.02.034
https://doi.org/10.1016/j.bbr.2015.02.034
Publikováno v:
Neurotoxicology and teratology. 66
The long-term effects of developmental alcohol and stress exposure are well documented in both humans and non-human animal models. Damage to the brain and attendant life-long impairments in cognition and increased risk for psychiatric disorders are d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02bd6c91af84726cd0e2df92b5138d0a
https://pubmed.ncbi.nlm.nih.gov/29305195
https://pubmed.ncbi.nlm.nih.gov/29305195
Publikováno v:
Developmental psychobiology. 59(6)
Early life adversity is known to disrupt behavioral trajectories and many rodent models have been developed to characterize these stress-induced outcomes. One example is the scarcity-adversity model of low nesting resources. This model employs resour
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1d309820c023e5a3e6e0507302eeafa
https://pubmed.ncbi.nlm.nih.gov/28767135
https://pubmed.ncbi.nlm.nih.gov/28767135