Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Samantha M, Meyer"'
Autor:
Samantha M. Meyer, Toru Tanaka, Patrick R. A. Zanon, Jared T. Baisden, Daniel Abegg, Xueyi Yang, Yoshihiro Akahori, Zainab Alshakarchi, Michael D. Cameron, Alexander Adibekian, Matthew D. Disney
Publikováno v:
Journal of the American Chemical Society. 144:21096-21102
Ribonuclease targeting chimeras (RiboTACs) induce degradation of an RNA target by facilitating an interaction between an RNA and a ribonuclease (RNase). We describe the screening of a DNA-encoded library (DEL) to identify binders of monomeric RNase L
Autor:
Jessica A, Bush, Samantha M, Meyer, Rita, Fuerst, Yuquan, Tong, Yue, Li, Raphael I, Benhamou, Haruo, Aikawa, Patrick R A, Zanon, Quentin M R, Gibaut, Alicia J, Angelbello, Tania F, Gendron, Yong-Jie, Zhang, Leonard, Petrucelli, Torben, Heick Jensen, Jessica L, Childs-Disney, Matthew D, Disney
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(48)
A hexanucleotide repeat expansion in intron 1 of the
Autor:
Jessica A. Bush, Samantha M. Meyer, Rita Fuerst, Yuquan Tong, Yue Li, Raphael I. Benhamou, Haruo Aikawa, Patrick R. A. Zanon, Quentin M. R. Gibaut, Alicia J. Angelbello, Tania F. Gendron, Yong-Jie Zhang, Leonard Petrucelli, Torben Heick Jensen, Jessica L. Childs-Disney, Matthew D. Disney
Publikováno v:
Bush, J A, Meyer, S M, Fuerst, R, Tong, Y, Li, Y, Benhamou, R I, Aikawa, H, Zanon, P R A, Gibaut, Q M R, Angelbello, A J, Gendron, T F, Zhang, Y J, Petrucelli, L, Heick Jensen, T, Childs-Disney, J L & Disney, M D 2022, ' A blood-brain penetrant RNA-targeted small molecule triggers elimination of r(G 4 C 2 ) exp in c9ALS/FTD via the nuclear RNA exosome ', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 48, e2210532119 . https://doi.org/10.1073/pnas.2210532119
A hexanucleotide repeat expansion in intron 1 of the C9orf72 gene is the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia, or c9ALS/FTD. The RNA transcribed from the expansion, r(G 4 C 2 ) exp , causes various pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d99afbe6d3582820279ae53936a1dca4
https://pure.au.dk/portal/da/publications/a-bloodbrain-penetrant-rnatargeted-small-molecule-triggers-elimination-of-rg4c2exp-in-c9alsftd-via-the-nuclear-rna-exosome(c64b1cee-2f4b-4d36-8329-562cc33c1c4c).html
https://pure.au.dk/portal/da/publications/a-bloodbrain-penetrant-rnatargeted-small-molecule-triggers-elimination-of-rg4c2exp-in-c9alsftd-via-the-nuclear-rna-exosome(c64b1cee-2f4b-4d36-8329-562cc33c1c4c).html
Autor:
Yuquan Tong, Peiyuan Zhang, Jessica L. Childs-Disney, Alexander Adibekian, Michael D. Cameron, Gogce Crynen, Matthew D. Disney, Samantha M. Meyer, Xiaohui Liu, Toru Tanaka, Daniel Abegg, Arnab K. Chatterjee, Raphael I. Benhamou, Jared T. Baisden
Publikováno v:
J Am Chem Soc
Reprogramming known medicines for a novel target with activity and selectivity over the canonical target is challenging. By studying the binding interactions between RNA folds and known small-molecule medicines and mining the resultant dataset across
Autor:
Kye Won Wang, Simon Vezina-Dawod, Matthew D. Disney, Raphael I. Benhamou, Ilyas Yildirim, Shruti Choudhary, Samantha M. Meyer
Publikováno v:
Chembiochem
RNA molecules both contribute to and are causative of many human diseases. One method to perturb RNA function is to target its structure with small molecules. However, discovering bioactive ligands for RNA targets is challenging. Here, we show that t
Autor:
Samantha M. Meyer, Collin A. O’Leary, Jessica L. Childs-Disney, Andrei Ursu, Alicia J. Angelbello, Walter N. Moss, Matthew D. Disney, Ryan J. Andrews
Publikováno v:
Chem Soc Rev
The design and discovery of small molecule medicines has largely been focused on a small number of druggable protein families. A new paradigm is emerging, however, in which small molecules exert a biological effect by interacting with RNA, both to st
Autor:
Jeffrey D. Rothstein, Jonathan L. Chen, Montina Van Meter, Tania F. Gendron, Alyssa N. Coyne, Yong Jie Zhang, Eric T. Wang, Yue Li, Ilyas Yildirim, Rita Fuerst, Jessica A. Bush, Leonard Petrucelli, Samantha M. Meyer, Hailey Olafson, Jessica L. Childs-Disney, Kye Won Wang, Yuquan Tong, Kendra K. McKee, Raphael I. Benhamou, Tanya Khan, Andrei Ursu, Matthew D. Disney, Sarah Wagner-Griffin, Haruo Aikawa
Publikováno v:
Sci Transl Med
The most common cause of amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FTD) is an expanded G(4)C(2) RNA repeat [r(G(4)C(2))(exp)] in chromosome 9 open reading frame 72 (C9orf72), which elicits pathology through several mechanisms.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c7323437f11575a5a155e154c7f4b4
https://europepmc.org/articles/PMC9533739/
https://europepmc.org/articles/PMC9533739/
Autor:
Jessica L. Childs-Disney, Samantha M. Meyer, Yuquan Tong, Jessica A. Bush, Christopher C. Williams, Matthew D. Disney, Hafeez S. Haniff
Publikováno v:
ACS Chem Biol
The interrogation and manipulation of biological systems by small molecules is a powerful approach in chemical biology. Ideal compounds selectively engage a target and mediate a downstream phenotypic response. Although historically small molecule dru
Autor:
Laurent Knerr, Hafeez S. Haniff, Samantha M. Meyer, Alexander Adibekian, Haruo Aikawa, Malin Lemurell, Xiaohui Liu, Daniel Abegg, Matthew D. Disney, Yuquan Tong
Publikováno v:
Cell Chem Biol
Summary MicroRNA families are ubiquitous in the human transcriptome, yet targeting of individual members is challenging because of sequence homology. Many secondary structures of the precursors to these miRNAs (pri- and pre-miRNAs), however, are quit
Autor:
Yoshihiro Akahori, Jessica L. Childs-Disney, Toru Tanaka, Christopher C. Williams, Samantha M. Meyer, Haruo Aikawa, Matthew D. Disney, Yuquan Tong
Publikováno v:
Chem Soc Rev
Targeting RNAs with small molecules represents a new frontier in drug discovery and development. The rich structural diversity of folded RNAs offers a nearly unlimited reservoir of targets for small molecules to bind, similar to small molecule occupa