Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Samantha Louisa Brown"'
Autor:
Jonathan M. Barford, Victoria J. Bolton, Geoffrey Stemp, Shiyam Mohamed, Stephen Christopher Martin Fell, Christopher N. Johnson, Gareth J. Sanger, David MacPherson, Samantha Louisa Brown, Chermaine Cluff, Darren Jason Mitchell, Sadhia R. Mahmood, Fiona McKay, Beverley Smith, Jon T. Seal, James Myatt, Alison I. Muir, Mervyn Thompson, Kim L. Matthews, Kirk Lawless, Steven J. Stanway, Emma M. Jarvie, Alexander J. Stevens, Susan Marie Westaway
Publikováno v:
Journal of medicinal chemistry. 52(4)
N-(3-Fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine 12 (GSK962040) is a novel small molecule motilin receptor agonist. It possesses excellent activity at the recombinant human motilin receptor and also at the
Autor:
Andrea Colombo, Izzy Boyfield, Christopher N. Johnson, Alessandra Consonni, Emma M. Jarvie, Victoria J. Bolton, Darren Jason Mitchell, Paolo Celestini, Michael A. Briggs, Sharon C Stratton, James Myatt, Geoffrey Stemp, David MacPherson, Alexander J. Stevens, Jon T. Seal, Stefania Gagliardi, Steven J. Stanway, Macdonald Gregor James, Mauro Riccaboni, Kate Lapsley, Susan Marie Westaway, Silvano Ronzoni, Gareth J. Sanger, Tom D. Heightman, Kim L. Matthews, Samantha Louisa Brown, Mervyn Thompson, Elizabeth Conway
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(24)
Optimisation of urea (5), identified from high throughput screening and subsequent array chemistry, has resulted in the identification of pyridine carboxamide (33) which is a potent motilin receptor agonist possessing favourable physicochemical and A