Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Samantha Laber"'
Autor:
Julius Honecker, Stefan Ruschke, Claudine Seeliger, Samantha Laber, Sophie Strobel, Priska Pröll, Christoffer Nellaker, Cecilia M. Lindgren, Ulrich Kulozik, Josef Ecker, Dimitrios C. Karampinos, Melina Claussnitzer, Hans Hauner
Publikováno v:
EBioMedicine, Vol 79, Iss , Pp 104020- (2022)
Summary: Background: The adipocyte-hypertrophy associated remodeling of fat cell function is considered causal for the development of metabolic disorders. A better understanding of transcriptome and fatty acid (FA) related alterations with adipocyte
Externí odkaz:
https://doaj.org/article/8ca88a6bac474c2aaf4c512d3c688d69
Autor:
Triin Laisk, Ana Luiza G. Soares, Teresa Ferreira, Jodie N. Painter, Jenny C. Censin, Samantha Laber, Jonas Bacelis, Chia-Yen Chen, Maarja Lepamets, Kuang Lin, Siyang Liu, Iona Y. Millwood, Avinash Ramu, Jennifer Southcombe, Marianne S. Andersen, Ling Yang, Christian M. Becker, Anders D. Børglum, Scott D. Gordon, Jonas Bybjerg-Grauholm, Øyvind Helgeland, David M. Hougaard, Xin Jin, Stefan Johansson, Julius Juodakis, Christiana Kartsonaki, Viktorija Kukushkina, Penelope A. Lind, Andres Metspalu, Grant W. Montgomery, Andrew P. Morris, Ole Mors, Preben B. Mortensen, Pål R. Njølstad, Merete Nordentoft, Dale R. Nyholt, Margaret Lippincott, Stephanie Seminara, Andres Salumets, Harold Snieder, Krina Zondervan, Thomas Werge, Zhengming Chen, Donald F. Conrad, Bo Jacobsson, Liming Li, Nicholas G. Martin, Benjamin M. Neale, Rasmus Nielsen, Robin G. Walters, Ingrid Granne, Sarah E. Medland, Reedik Mägi, Deborah A. Lawlor, Cecilia M. Lindgren
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Miscarriage affects around 15% of clinically confirmed pregnancies. Here the authors carry out a large genome-wide association study for sporadic and multiple consecutive miscarriage and suggest links with placental biology.
Externí odkaz:
https://doaj.org/article/bdd3d54f8cfb46f29d8530d41ddbc34a
Autor:
Craig A Glastonbury, Sara L Pulit, Julius Honecker, Jenny C Censin, Samantha Laber, Hanieh Yaghootkar, Nilufer Rahmioglu, Emilie Pastel, Katerina Kos, Andrew Pitt, Michelle Hudson, Christoffer Nellåker, Nicola L Beer, Hans Hauner, Christian M Becker, Krina T Zondervan, Timothy M Frayling, Melina Claussnitzer, Cecilia M Lindgren
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 8, p e1008044 (2020)
Genetic studies have recently highlighted the importance of fat distribution, as well as overall adiposity, in the pathogenesis of obesity-associated diseases. Using a large study (n = 1,288) from 4 independent cohorts, we aimed to investigate the re
Externí odkaz:
https://doaj.org/article/ece9574c1c2a4be88137af51b58a2170
Autor:
Grace T. Hansen, Débora R. Sobreira, Zachary T. Weber, Alexis G. Thornburg, Ivy Aneas, Li Zhang, Noboru J. Sakabe, Amelia C. Joslin, Gabriela A. Haddad, Sophie M. Strobel, Samantha Laber, Farhath Sultana, Faezeh Sahebdel, Kohinoor Khan, Yang I. Li, Melina Claussnitzer, Liang Ye, Ricardo A. Battaglino, Marcelo A. Nóbrega
Publikováno v:
Nature Genetics. 55:461-470
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ed2a5480ebc07311ae545c7d9979da4
https://doi.org/10.1038/s41588-023-01306-0
https://doi.org/10.1038/s41588-023-01306-0
Autor:
Kristi Krebs, Jenny C Censin, Sara L. Pulit, Ruth Boxall, Iona Y Millwood, Teresa Ferreira, Chia-Yen Chen, Robin G. Walters, Reedik Mägi, Benjamin M. Neale, Kuang Lin, Liming Li, Jonas Bovijn, Lili Milani, Samantha Laber, Craig A. Glastonbury, George Davey Smith, Cecilia M. Lindgren, Zhengming Chen, Michael V. Holmes
Publikováno v:
Science translational medicine. 13(622)
Triangulation of evidence from clinical trials and human genetics suggests a potential excess risk of cardiovascular disease events arising from therapeutic inhibition of sclerostin.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16710246c0dfc0f73d432c1b622ac42e
https://pubmed.ncbi.nlm.nih.gov/34851692
https://pubmed.ncbi.nlm.nih.gov/34851692
Autor:
Christoffer Nellåker, Stefan Ruschke, Melina Claussnitzer, Dimitrios C. Karampinos, C M Lindgren, Sophie Strobel, Samantha Laber, Hans Hauner, Ulrich Kulozik, Julius Honecker, P. Proell, J. Ecker, C. Seeliger
Adipose tissue is an organ with great plasticity and its hypertrophic expansion is associated with adipocyte dysfunction. How changes in adipocyte morphology are linked to gene expression and which cellular functions are affected remains elusive. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6184cb557225f0598e34e0ac563a7ad2
https://doi.org/10.1101/2021.11.20.468818
https://doi.org/10.1101/2021.11.20.468818
Autor:
Angelica Di Vincenzo, Molly L. Veregge, Samuel J. Lin, Christopher G. Boyd, Adam Essene, Elizabeth McGonagle, Zachary Kramer, Melina Claussnitzer, Anja Jørgensen, Samantha Laber, Tune H. Pers, Margo P. Emont, Antonio Giordano, Eleanna De Filippis, Christopher Jacobs, Aviv Regev, Georgia Colleluori, Deepti Pant, William Gourash, Anton Gulko, Saaket Agrawal, Gregory P. Westcott, Danielle Tenen, Erin Merkel, Anita P. Courcoulas, Linus Tsai, Sophie Strobel, Adam Stefek, Evan D. Rosen, Orr Ashenberg, Hesam Dashti, Harini Srinivasan, Jennifer Ducie, Donald Morris, Bernard T. Lee, Amrita Kar, Amit Khera, Adam M. Tobias
White adipose tissue (WAT), once regarded as morphologically and functionally bland, is now recognized to be dynamic, plastic, heterogenous, and involved in a wide array of biological processes including energy homeostasis, glucose and lipid handling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b64205c47b354a8b6533c3b86b88af0
https://doi.org/10.1101/2021.11.09.466968
https://doi.org/10.1101/2021.11.09.466968
Autor:
Garrett Garborcauskas, Alycen Harney, Hesam Dashti, Anne E. Carpenter, Miriam S. Udler, Elizabeth McGonagle, Aaron Leong, Hannah Ebert, Josée Dupuis, Maria Kost-Alimova, Cecilia M. Lindgren, Sierra Harken, Giacomo Deodato, Hans Hauner, Beth A. Cimini, Suzanne B.R. Jacobs, Josep M. Mercader, Saskia Reibe-Pal, Jose C. Florez, Adam Stefek, Samantha Laber, David R. Stirling, Gregory P. Way, Nasa Sinnott-Armstrong, Katherine Figueroa, Julius Honecker, Alham Saadat, Alina Ainbinder, Virtudes Calabuig, Melina Claussnitzer, Yixin Zhang, Sophie Strobel
SummaryA primary obstacle in translating genetics and genomics data into therapeutic strategies is elucidating the cellular programs affected by genetic variants and genes associated with human diseases. Broadly applicable high-throughput, unbiased a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16e99c4f7b03bd908d4d964e2603077b
https://doi.org/10.1101/2021.07.17.452050
https://doi.org/10.1101/2021.07.17.452050
Autor:
Franco Moritz, Melina Claussnitzer, Roger D. Cox, Kirill S. Smirnov, Julius Honecker, Philippe Schmitt-Kopplin, Sophie Strobel, Wendy A. Bickmore, Julia Petzold, Tom Nicol, Michelle Simon, Samantha Laber, Lydia Teboul, Sara Forcisi, Hans Hauner, Harald Grallert, Shahana Sengupta, Loubna Al Sadat, Liz Bentley, Iain Williamson, Margit Heier, Joffrey Mianné, Helen S Long, Thomas Agnew, Cecilia M. Lindgren, Rebecca Dumbell
Publikováno v:
Science Advances
The obesity-linked FTO regulatory circuitry shows cross-species molecular, cellular, metabolic, and organismal conservation.
Variants in FTO have the strongest association with obesity; however, it is still unclear how those noncoding variants m
Variants in FTO have the strongest association with obesity; however, it is still unclear how those noncoding variants m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a22ffadc36c6491bd827637674e7497
http://europepmc.org/articles/PMC8294759
http://europepmc.org/articles/PMC8294759
Autor:
Michael V. Holmes, Samantha Laber, Benjamin M. Neale, Jenny C Censin, Z Chen, Kuang Lin, Robin G. Walters, Kristi Krebs, Reedik Mägi, Jonas Bovijn, Iona Y. Millwood, Ruth Boxall, Cecilia M. Lindgren, Liheng Li, Lili Milani, Sara L. Pulit, Teresa Ferreira, Craig A. Glastonbury, Chiao-Lin Chen
BackgroundInhibition of sclerostin is a novel therapeutic approach to lowering fracture risk. However, phase III randomised controlled trials (RCTs) of romosozumab, a monoclonal antibody that inhibits sclerostin, suggest an imbalance of serious cardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e31dcbffef9f8d6969bfbaedb5cf5e1f
https://ora.ox.ac.uk/objects/uuid:30e188a5-d1c8-4255-b2a4-da4440922f3f
https://ora.ox.ac.uk/objects/uuid:30e188a5-d1c8-4255-b2a4-da4440922f3f