Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Samantha L. Shepherd"'
Autor:
Hana Kostrhunova, Roger M. Phillips, Hannah E. Bridgewater, Samantha L. Shepherd, Simon J. Allison, Nicola J. Rogers, Viktor Brabec, Jana Kasparkova, Jitka Pracharova, Vojtech Novohradsky, Peter Scott, Hualong Song
Publikováno v:
Angewandte Chemie (International Ed. in English)
Monosaccharides are added to the hydrophilic face of a self‐assembled asymmetric FeII metallohelix, using CuAAC chemistry. The sixteen resulting architectures are water‐stable and optically pure, and exhibit improved antiproliferative selectivity
Autor:
Miles Postings, Samantha L. Shepherd, Roger M. Phillips, Peter Scott, Viktor Brabec, Guy J. Clarkson, Hana Kostrhunova, Nicola J. Rogers, Hualong Song, James P. C. Coverdale
Publikováno v:
Chemical Communications. 56:6392-6395
Functionalised triazole aldehydes are used in the highly selective self-assembly of water-compatible, optically pure, low symmetry Fe(ii)- and Zn(ii)-based metallohelices. Sub-micromolar antiproliferative activity is observed against various cancerou
Autor:
Nicola William, Roger M. Phillips, Christopher M. Pask, Andrew Nelson, Helen A. Blundell, Benjamin R. M. Lake, Madhurima Das, Charlotte E. Willans, Samantha L. Shepherd, Heba A. Mohamed
With the aim of combining the potential anticancer properties of both clotrimazole, an imidazole based antifungal agent, and silver(I) N-heterocyclic carbenes, 13 novel silver(I) N-heterocyclic carbene complexes derived from clotrimazole were synthes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae2005fa817fe407ae7462de4d916d3d
https://eprints.whiterose.ac.uk/159322/1/Organometallics_Final_Revised.pdf
https://eprints.whiterose.ac.uk/159322/1/Organometallics_Final_Revised.pdf
Autor:
Mthulisi Khuphe, Heba A. Mohamed, Charlotte E. Willans, Samantha L. Shepherd, Roger M. Phillips, S. J. Boardman, Paul D. Thornton
Publikováno v:
RSC Advances. 8:10474-10477
Amphiphilic block copolymers have been developed for the encapsulation of organometallic drugs. silver-N-heterocyclic carbene complexes have shown significant promise as anticancer and antibacterial compounds, and have been studied as the payload in
Autor:
Mahesh Kalidasan, Basava Punna Rao Aradhyula, Krishna Mohan Poluri, Samantha L. Shepherd, Mohan Rao Kollipara, Debojit Kumar Deb, Krishnakant Gangele, Roger M. Phillips
Publikováno v:
ChemistrySelect. 2:2065-2076
The reaction of metal precursors {[Cp*MCl2]2 (M=Rh, Ir)} with 2- aminopyrimidine (L1) gave binuclear complexes as [(Cp*MCl2)2 (m-L1)], where L1 acted as a bridging ligand. While 2- mercaptopyrimidine (L2) with [Cp*MCl2]2 {M=Rh(III), Ir(III)} formed m
Autor:
Simon J. Allison, Nicola J. Rogers, Hualong Song, Peter Scott, Lenka Markova, Roger M. Phillips, Juraj Zajac, Emma Pinder, Hana Kostrhunova, Viktor Brabec, Hannah E. Bridgewater, Samantha L. Shepherd, Lawrence S. Young
Helicates and related metallofoldamers, synthesised by dynamic self-assembly, represent an area of chemical space inaccessible by traditional organic synthesis, and yet with potential for discovery of new classes of drug. Here we report that water-so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5999c9e29faf5f3ce9847a56ab1b5d4f
http://wrap.warwick.ac.uk/123991/1/WRAP-discovery-selective-antimetastatic-anti-cancer-stem-cell-post-Scott-2019.pdf
http://wrap.warwick.ac.uk/123991/1/WRAP-discovery-selective-antimetastatic-anti-cancer-stem-cell-post-Scott-2019.pdf
Autor:
Mohan Rao Kollipara, Dipankar Sutradhar, Sanjay Adhikari, Samantha L. Shepherd, Asit K. Chandra, Werner Kaminsky, Narasinga Rao Palepu, Roger M. Phillips
Publikováno v:
Journal of Organometallic Chemistry. 820:70-81
The reaction of [(p-cymene)RuCl2]2 and [Cp*MCl2]2 (M = Rh/Ir) with chelating ligand 2-pyridyl cyanoxime {pyC(CN)NOH} leads to the formation of neutral oximato complexes having the general formula [(arene)M{pyC(CN)NO}Cl] {arene = p-cymene, M = Ru, (1)
Autor:
Daniel H. Simpson, Peter Scott, David I. Roper, Samantha L. Shepherd, Roger M. Phillips, Simon J. Allison, Rebecca A. Kaner, Alan D. Faulkner, Nicholas R. Waterfield
Publikováno v:
Chemical Science. 7:951-958
A range of new helicate-like architectures have been prepared via highly diastereoselective self-assembly using readily accessible starting materials. Six pairs of enantiomers [Fe2L3]Cl4.nH2O (L = various bidentate ditopic ligands NN–NN) show very
Autor:
Roger M. Phillips, Richard T. Wheelhouse, Christopher Dunnill, Nikolaos T. Georgopoulos, Steve D. Shnyder, Efstathia Baronou, Ayse Latif, Simon J. Allison, Maria Sadiq, Ian J. Stratford, Charlotte E. Willans, Samantha L. Shepherd, Patricia A. Cooper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::525ab33160b9b3d6aefd6bb98ec94c97
Autor:
Robert A. Faulkner, Craig R. Rice, Owen J. Harper, Roger M. Phillips, David J. Cooke, Samantha L. Shepherd, Simon J. Allison, Richard T. Wheelhouse, Hollie B. S. Griffiths, Omar Khadeer Hussain, Paul I. P. Elliott, Francesca S. Davidson, P. Jane Owen-Lynch
Publikováno v:
Allison, S J, Cooke, D, Davidson, F S, Elliott, P I P, Faulkner, R A, Griffiths, H B S, Harper, O, Hussain, O, Owen-Lynch, P J, Phillips, R M, Rice, C R, Shepherd, S L & Wheelhouse, R T 2018, ' Ruthenium-Containing Linear Helicates and Mesocates with Tuneable p53-Selective Cytotoxicity in Colorectal Cancer Cells ', Angewandte Chemie-International Edition, vol. 57, no. 31, pp. 9799-9804 . https://doi.org/10.1002/anie.201805510
The ligands L1 and L2 both form separable dinuclear double-stranded helicate and mesocate complexes with RuII . In contrast to clinically approved platinates, the helicate isomer of [Ru2 (L1 )2 ]4+ was preferentially cytotoxic to isogenic cells (HCT1