Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Samantha L. Deitz"'
Autor:
Douglas D. Baumann, Joshua D. Blazek, Andrew Darrah, Rebecca W. Doerge, Brad C. Long, Brandon Young, Samantha L. Deitz, Randall J. Roper, Cherie N. Billingsley, Mark J. Clement, Jared Allen, Abby Newbauer
Publikováno v:
American Journal of Medical Genetics Part A. 161:1866-1874
Trisomy 21 in humans causes cognitive impairment, craniofacial dysmorphology, and heart defects collectively referred to as Down syndrome. Yet, the pathophysiology of these phenotypes is not well understood. Craniofacial alterations may lead to compl
Pancreatic ductal adenocarcinoma (PDAC) is often associated with overexpression of TGF-β. Given its tumor suppressor functions, it is unclear whether TGF-β is a valid therapeutic target for PDAC. Here, we found that proliferating pancreatic cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e0b46d1763d054dffefe933a02d45e
https://europepmc.org/articles/PMC4922702/
https://europepmc.org/articles/PMC4922702/
Autor:
Samantha L. Deitz, Randall J. Roper
Publikováno v:
Genetics. 189:1487-1495
Individuals with full or partial Trisomy 21 (Ts21) present with clinical features collectively referred to as Down syndrome (DS), although DS phenotypes vary in incidence and severity between individuals. Differing genetic and phenotypic content in i
Publikováno v:
Genetics and Etiology of Down Syndrome
1.1 Trisomy 21 causes phenotypes associated with Down syndrome Down syndrome (DS) occurs in approximately 1 out of 700 live births and most commonly results from three copies of human chromosome 21 (Hsa21) (Christianson, 2006). DS is a multifaceted d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d93738a3f2bdf1de7ac35e8d3ca3360b
http://www.intechopen.com/articles/show/title/down-syndrome-a-complex-and-interactive-genetic-disorder
http://www.intechopen.com/articles/show/title/down-syndrome-a-complex-and-interactive-genetic-disorder
Publikováno v:
Cancer Research. 74:969-969
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy, associated with a high frequency of KRAS mutations (95%) and loss of negative growth constraints, due, in part, to frequent CDKN2A (85%), TP53 (75%) and SMAD4 (55%) mutations. PDACs also