Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Samantha L. Bell"'
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT Mycobacterium tuberculosis (Mtb) causes one of the deadliest infectious diseases worldwide. Upon infection, Mtb is phagocytosed by macrophages and uses its virulence-associated ESX-1 secretion system to modulate the host cell. We showed prev
Externí odkaz:
https://doaj.org/article/adcda7fd76914fb3b611f58e30465cdc
Autor:
Shengli Ding, Jing Yang, Xuehuan Feng, Aseem Pandey, Rola Barhoumi, Dongmei Zhang, Samantha L. Bell, Yue Liu, Luciana Fachini da Costa, Allison Rice-Ficht, Robert O. Watson, Kristin L. Patrick, Qing-Ming Qin, Thomas A. Ficht, Paul de Figueiredo
Publikováno v:
iScience, Vol 24, Iss 3, Pp 102192- (2021)
Summary: Phagocytosis and autophagy play critical roles in immune defense. The human fungal pathogen Cryptococcus neoformans (Cn) subverts host autophagy-initiation complex (AIC)-related proteins, to promote its phagocytosis and intracellular parasit
Externí odkaz:
https://doaj.org/article/781b61b7f057420badddeadb975d168c
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
Despite major strides in personalized genomics, it remains poorly understood why neurodegenerative diseases occur in only a fraction of individuals with a genetic predisposition and conversely, why individuals with no genetic risk of a disorder devel
Externí odkaz:
https://doaj.org/article/7ef31ad37ecb4f4985b0f73323654c76
Autor:
Chi G Weindel, Samantha L Bell, Krystal J Vail, Kelsi O West, Kristin L Patrick, Robert O Watson
Publikováno v:
eLife, Vol 9 (2020)
The Parkinson’s disease (PD)-associated gene leucine-rich repeat kinase 2 (LRRK2) has been studied extensively in the brain. However, several studies have established that mutations in LRRK2 confer susceptibility to mycobacterial infection, suggest
Externí odkaz:
https://doaj.org/article/4caa4bf04ba84861995ba7c4bd7c84fd
Autor:
Tao Jing, Jeffery S. Cox, Kelsi O West, Pingwei Li, Kristin L. Patrick, Robert O. Watson, Allison R Wagner, A. Phillip West, Sylvia Torres-Odio, Samantha L. Bell, Caitlyn T. Hoffpauir
Publikováno v:
J Immunol
Tripartite motif-containing proteins (TRIMs) play a variety of recently described roles in innate immunity. Although many TRIMs regulate type I IFN expression following cytosolic nucleic acid sensing of viruses, their contribution to innate immune si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::556cf515744928016485d01393233fef
https://doi.org/10.4049/jimmunol.1901511
https://doi.org/10.4049/jimmunol.1901511
Autor:
Jason Karpac, Baoyu Zhao, Pingwei Li, Chi G Weindel, Cory Mabry, Kristin L. Patrick, Eduardo R. Martinez, Phillip West, Aja K. Coleman, Jordan J VanPortfliet, Krystal J Vail, Xiao Zhao, Robert O. Watson, Samantha L Bell
SUMMARYHuman mutations in mitochondrial-associated genes are associated with inflammatory diseases and susceptibility to infection. However, their mechanistic contributions to immune outcomes remain ill-defined. We discovered that the disease-associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9e2f7252780f4ed937aacbe248e920a
https://doi.org/10.1101/2021.11.18.469014
https://doi.org/10.1101/2021.11.18.469014
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
mBio
mBio
Mycobacterium tuberculosis (Mtb) causes one of the deadliest infectious diseases worldwide. Upon infection, Mtb is phagocytosed by macrophages and uses its virulence-associated ESX-1 secretion system to modulate the host cell. We showed previously th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bafcc6ecaf7abb75e360443d7f272dfd
https://journals.asm.org/doi/10.1128/mBio.01871-20
https://journals.asm.org/doi/10.1128/mBio.01871-20
Autor:
Yang Liu, Pengbiao Xu, Jun-Yuan Ji, Xiaofeng Fu, Mengmeng Liu, Fenglei Du, Baoyu Zhao, Samantha L. Bell, Fanxiu Zhu, Arthur Laganowsky, Yuanjiu Lei, Pingwei Li, A. Philip West, Xinsheng Gao, Chang Shu, Banumathi Sankaran, Robert O. Watson, Xueyun Zheng
Publikováno v:
Nature
Nature, vol 569, iss 7758
Nature, vol 569, iss 7758
Nucleic acids from bacteria or viruses induce potent immune responses in infected cells1-4. The detection of pathogen-derived nucleic acids is a central strategy by which the host senses infection and initiates protective immune responses5,6. Cyclic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d3c9e1444d72ffdc524911895f0c75
https://doi.org/10.1038/s41586-019-1228-x
https://doi.org/10.1038/s41586-019-1228-x
Autor:
Chi G. Weindel, Eduardo L. Martinez, Xiao Zhao, Cory J. Mabry, Samantha L. Bell, Krystal J. Vail, Aja K. Coleman, Jordyn J. VanPortfliet, Baoyu Zhao, Allison R. Wagner, Sikandar Azam, Haley M. Scott, Pingwei Li, A. Phillip West, Jason Karpac, Kristin L. Patrick, Robert O. Watson
Publikováno v:
Cell. 185:3214-3231.e23
Although mutations in mitochondrial-associated genes are linked to inflammation and susceptibility to infection, their mechanistic contributions to immune outcomes remain ill-defined. We discovered that the disease-associated gain-of-function allele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa1c9c6f5595b9edba7b01127d4e15a6
https://doi.org/10.1016/j.cell.2022.06.038
https://doi.org/10.1016/j.cell.2022.06.038
Autor:
A. Phillip West, Robert O. Watson, Camila Guerra Martinez, Joshua D. Bryant, Sylvia Torres-Odio, Samantha L. Bell, Yuanjiu Lei, Carl W. Tong, Christine E. Birdwell, Laura Ciaccia West
Publikováno v:
Science Advances. 7
Mitochondrial dysfunction is a key driver of inflammatory responses in human disease. However, it remains unclear whether alterations in mitochondria-innate immune cross-talk contribute to the pathobiology of mitochondrial disorders and aging. Using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7108e75f2d535be54d4f32994e544b20
https://doi.org/10.1126/sciadv.abe7548
https://doi.org/10.1126/sciadv.abe7548