Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Samantha L Shapiro"'
Autor:
Megan M. Braun, Brendan K. Sheehan, Samantha L. Shapiro, Yun Ding, C. Dustin Rubinstein, Brent P. Lehman, Luigi Puglielli
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The acetylation of autophagy protein 9 A (ATG9A) in the lumen of the endoplasmic reticulum (ER) by ATase1 and ATase2 regulates the induction of reticulophagy. Analysis of the ER-specific ATG9A interactome identified calreticulin (CALR), an E
Externí odkaz:
https://doaj.org/article/d24d33a0c06c4f248fa721c030b43bd0
Autor:
Peng Liu, Jennifer B Paulson, Colleen L Forster, Samantha L Shapiro, Karen H Ashe, Kathleen R Zahs
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126317 (2015)
Amyloid plaques composed of β-amyloid (Aβ) protein are a pathological hallmark of Alzheimer's disease. We here report the generation and characterization of a novel transgenic mouse model of Aβ toxicity. The rTg9191 mice harbor a transgene encodin
Externí odkaz:
https://doaj.org/article/d5e49ffb28e44ff3b5acdc4a0130a87f
Autor:
Peng Liu, Ian P. Lapcinski, Chris J.W. Hlynialuk, Elizabeth L. Steuer, Thomas J. Loude, Jr., Samantha L. Shapiro, Lisa J. Kemper, Karen H. Ashe
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109239- (2024)
Summary: Amyloid-β (Aβ) oligomers consist of fibrillar and non-fibrillar soluble assemblies of the Aβ peptide. Aβ∗56 is a non-fibrillar Aβ assembly that is linked to memory deficits. Previous studies did not decipher specific forms of Aβ pres
Externí odkaz:
https://doaj.org/article/56a892ea96cc4957b37db5007c790916
Autor:
Gonzalo Fernandez-Fuente, Katherine A. Overmyer, Alexis J. Lawton, Ildiko Kasza, Samantha L. Shapiro, Patricia Gallego-Muñoz, Joshua J. Coon, John M. Denu, Caroline M. Alexander, Luigi Puglielli
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-17 (2023)
Abstract Cytosolic citrate is imported from the mitochondria by SLC25A1, and from the extracellular milieu by SLC13A5. In the cytosol, citrate is used by ACLY to generate acetyl-CoA, which can then be exported to the endoplasmic reticulum (ER) by SLC
Externí odkaz:
https://doaj.org/article/431bd0466cac4c12b1c6a4333e671895
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102315- (2021)
Summary: The acetylation of ATG9A within the endoplasmic reticulum (ER) lumen regulates the induction of reticulophagy. ER acetylation is ensured by AT-1/SLC33A1, a membrane transporter that maintains the cytosol-to-ER flux of acetyl-CoA. Defective A
Externí odkaz:
https://doaj.org/article/81a9a530c93a49ca93533c48bb9490b0
Publikováno v:
bioRxiv
SummaryAmyloid-β (Aβ) oligomers consist of fibrillar and non-fibrillar soluble assemblies of the Aβ peptide. Tg2576 human amyloid precursor protein (APP)-expressing transgenic mice modeling Alzheimer’s disease produce Aβ*56, a non-fibrillar Aβ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::773ce36d2865b3354fa7296738e9c14b
https://europepmc.org/articles/PMC10055265/
https://europepmc.org/articles/PMC10055265/
Increased expression of SLC25A1/CIC causes an autistic-like phenotype with altered neuron morphology
Autor:
Michael J Rigby, Nicola Salvatore Orefice, Alexis J Lawton, Min Ma, Samantha L Shapiro, Sue Y Yi, Inca A Dieterich, Alyssa Frelka, Hannah N Miles, Robert A Pearce, John Paul J Yu, Lingjun Li, John M Denu, Luigi Puglielli
Publikováno v:
Brain
N ε-lysine acetylation within the lumen of the endoplasmic reticulum is a recently characterized protein quality control system that positively selects properly folded glycoproteins in the early secretory pathway. Overexpression of the endoplasmic r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0141f753d72ad5bef1dc9fba2d96b901
https://europepmc.org/articles/PMC9014753/
https://europepmc.org/articles/PMC9014753/
Autor:
Michael J. Rigby, Nicola Salvatore Orefice, Alexis J. Lawton, Min Ma, Samantha L. Shapiro, Sue Y. Yi, Inca A. Dieterich, Alyssa Frelka, Hannah N. Miles, Robert A. Pearce, John Paul J. Yu, Lingjun Li, John M. Denu, Luigi Puglielli
Publikováno v:
Brain Commun
Endoplasmic reticulum-based Nɛ-lysine acetylation serves as an important protein quality control system for the secretory pathway. Dysfunctional endoplasmic reticulum-based acetylation, as caused by overexpression of the acetyl coenzyme A transporte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e355cef298e26220e614a3b6bb0f9ca6
https://pubmed.ncbi.nlm.nih.gov/35146426
https://pubmed.ncbi.nlm.nih.gov/35146426
Autor:
Samantha L. Shapiro, Brendan K. Sheehan, Nicola Salvatore Orefice, Yajing Peng, Luigi Puglielli
Publikováno v:
iScience
iScience, Vol 24, Iss 4, Pp 102315-(2021)
iScience, Vol 24, Iss 4, Pp 102315-(2021)
Summary The acetylation of ATG9A within the endoplasmic reticulum (ER) lumen regulates the induction of reticulophagy. ER acetylation is ensured by AT-1/SLC33A1, a membrane transporter that maintains the cytosol-to-ER flux of acetyl-CoA. Defective AT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27126e12aa8439c5fab984d02ea8ed77
http://europepmc.org/articles/PMC8042170
http://europepmc.org/articles/PMC8042170
Publikováno v:
Biological Procedures
Antibodies are commonly used to detect or isolate proteins from biological samples. Much attention has been paid to the potential for poorly-characterized antibodies to lead to misleading results, but antibody-independent artefacts may also occur. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc5fc9d0d9d69c60dcfdc3b9aeeed27f
https://doi.org/10.1186/s12575-019-0095-z
https://doi.org/10.1186/s12575-019-0095-z