Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Samantha L Regan"'
Autor:
Michael T Williams, Chiho Sugimoto, Samantha L Regan, Emily M Pitzer, Adam L Fritz, Mathieu Sertorio, Anthony E Mascia, Ralph E Vatner, John P Perentesis, Charles V Vorhees
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0274007 (2022)
Recent studies suggest that ultra-high dose rates of proton radiation (>40 Gy/s; FLASH) confer less toxicity to exposed healthy tissue and reduce cognitive decline compared with conventional radiation dose rates (~1 Gy/s), but further preclinical dat
Externí odkaz:
https://doaj.org/article/8cca211bfd4841748d9af0addd081e91
Autor:
Elizabeth A. Werren, Geneva R. LaForce, Anshika Srivastava, Delia R. Perillo, Shaokun Li, Katherine Johnson, Safa Baris, Brandon Berger, Samantha L. Regan, Christian D. Pfennig, Sonja de Munnik, Rolph Pfundt, Malavika Hebbar, Raúl Jimenez-Heredia, Elif Karakoc-Aydiner, Ahmet Ozen, Jasmin Dmytrus, Ana Krolo, Ken Corning, E. J. Prijoles, Raymond J. Louie, Robert Roger Lebel, Thuy-Linh Le, Jeanne Amiel, Christopher T. Gordon, Kaan Boztug, Katta M. Girisha, Anju Shukla, Stephanie L. Bielas, Ashleigh E. Schaffer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract THOC6 variants are the genetic basis of autosomal recessive THOC6 Intellectual Disability Syndrome (TIDS). THOC6 is critical for mammalian Transcription Export complex (TREX) tetramer formation, which is composed of four six-subunit THO mono
Externí odkaz:
https://doaj.org/article/377fd67c893b4d0eba289bde1408f26e
Autor:
Michael T. Williams, Chiho Sugimoto, Samantha L. Regan, Emily M. Pitzer, Adam L. Fritz, Anthony E. Mascia, Mathieu Sertorio, Ralph E. Vatner, John P. Perentesis, Charles V. Vorhees
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-20 (2020)
Abstract Proton radiotherapy causes less off-target effects than X-rays but is not without effect. To reduce adverse effects of proton radiotherapy, a model of cognitive deficits from conventional proton exposure is needed. We developed a model empha
Externí odkaz:
https://doaj.org/article/5d32edd717014b9596a855396e69d6d1
Publikováno v:
Human Genetics.
Publikováno v:
Neurosci Biobehav Rev
Attention deficit hyperactivity disorder (ADHD) is a polygenic neurodevelopmental disorder that affects 8-12 % of children and4 % of adults. Environmental factors are believed to interact with genetic predispositions to increase susceptibility to ADH
Autor:
Monica S. Carbajal, Asiah J. C. Bounmy, Olivia B. Harrison, Hunter G. Nolen, Samantha L. Regan, Michael T. Williams, Charles V. Vorhees, Helen J. K. Sable
Publikováno v:
Frontiers in Neuroscience. 17
IntroductionImpulsivity is a symptom of attention-deficit/hyperactivity disorder (ADHD) and variants in the Lphn3 (Adgrl3) gene (OMIM 616417) have been linked to ADHD. This project utilized a delay-discounting (DD) task to examine the impact of Lphn3
Autor:
Elizabeth Werren, Geneva R. LaForce, Anshika Srivastava, Delia R. Perillo, Katherine Johnson, Safa Baris, Brandon Berger, Samantha L. Regan, Christian D. Pfennig, Sonja de Munnik, Rolph Pfundt, Malavika Hebbar, Raúl Jimenez-Heredia, Elif Karakoc-Aydiner, Ahmet Ozen, Jasmin Dmytrus, Ana Krolo, Ken Corning, EJ Prijoles, Raymond J. Louie, Robert R. Lebel, Thuy-Linh Le, Chris Gordon, Kaan Boztug, Katta M. Girish, Anju Shukla, Stephanie L. Bielas, Ashleigh E. Schaffer
THOC6 is the genetic basis of autosomal recessive THOC6 Intellectual Disability Syndrome (TIDS). THOC6 facilitates the formation of the Transcription Export complex (TREX) tetramer, composed of four THO monomers. The TREX tetramer supports mammalian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ac8b71ebc7267a1981ce55785b49439
https://doi.org/10.1101/2022.09.06.506502
https://doi.org/10.1101/2022.09.06.506502
Autor:
Emily M. Pitzer, Chiho Sugimoto, Samantha L. Regan, Gary A. Gudelsky, Michael T. Williams, Charles V. Vorhees
Publikováno v:
Current research in toxicology. 3
Pyrethroid pesticides are widely used and can cause long-term effects after early exposure. Epidemiological and animal studies reveal associations between pyrethroid exposure and altered cognition following prenatal and/or neonatal exposure. However,
Publikováno v:
Neurotoxicity Research. 39:543-555
The effects of permethrin (PRM) and deltamethrin (DLM) on acoustic or light prepulse inhibition of the acoustic startle response (ASR) and tactile startle response (TSR) were studied in adult male Sprague Dawley rats. Preliminary studies were conduct
Publikováno v:
Genes, brain, and behaviorREFERENCES. 21(7)
Latrophilin-3 (LPHN3) is a brain specific G-protein coupled receptor associated with increased risk of attention deficit hyperactivity disorder (ADHD) and cognitive deficits. CRISPR/Cas9 was used to generate a constitutive knockout (KO) rat of Lphn3