Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Samantha L Burton"'
Autor:
Tysheena P Charles, Samantha L Burton, Prabhu S Arunachalam, Christopher A Cottrell, Leigh M Sewall, Venkata S Bollimpelli, Sailaja Gangadhara, Antu K Dey, Andrew B Ward, George M Shaw, Eric Hunter, Rama R Amara, Bali Pulendran, Marit J van Gils, Cynthia A Derdeyn
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009257 (2021)
Stabilized HIV-1 envelope (Env) trimers elicit tier 2 autologous neutralizing antibody (nAb) responses in immunized animals. We previously demonstrated that BG505 SOSIP.664.T332N gp140 (BG505 SOSIP) immunization of rhesus macaques (RM) provided robus
Externí odkaz:
https://doaj.org/article/9eebb505e6de4f35a7e3bc5ad081b207
Autor:
S Abigail Smith, Samantha L Burton, William Kilembe, Shabir Lakhi, Etienne Karita, Matt Price, Susan Allen, Eric Hunter, Cynthia A Derdeyn
Publikováno v:
PLoS Pathogens, Vol 12, Iss 11, p e1005989 (2016)
A recent study of plasma neutralization breadth in HIV-1 infected individuals at nine International AIDS Vaccine Initiative (IAVI) sites reported that viral load, HLA-A*03 genotype, and subtype C infection were strongly associated with the developmen
Externí odkaz:
https://doaj.org/article/b2fb3eeb413d476095dd644d7475ec46
Autor:
Venkata S. Bollimpelli, Pradeep B. J Reddy, Sailaja Gangadhara, Tysheena P. Charles, Samantha L. Burton, Gregory K. Tharp, Tiffany M. Styles, Celia C. Labranche, Justin C. Smith, Amit A. Upadhyay, Anusmita Sahoo, Traci Legere, Ayalnesh Shiferaw, Vijayakumar Velu, Tianwei Yu, Mark Tomai, John Vasilakos, Sudhir P. Kasturi, George M. Shaw, David Montefiori, Steven E. Bosinger, Pamela A. Kozlowski, Bali Pulendran, Cynthia A. Derdeyn, Eric Hunter, Rama R. Amara
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Route of immunization can markedly influence the quality of immune response. Here, we show that intradermal (ID) but not intramuscular (IM) modified vaccinia Ankara (MVA) vaccinations provide protection from acquisition of intravaginal tier2
Externí odkaz:
https://doaj.org/article/101d7faa095245b791894f88734b70d5
Autor:
Kiran S. Toti, Nicole Pribut, Michael D’Erasmo, Madhuri Dasari, Savita K. Sharma, Perry W. Bartsch, Samantha L. Burton, Hannah B. Gold, Anatoliy Bushnev, Cynthia A. Derdeyn, Adriaan E. Basson, Dennis C. Liotta, Eric J. Miller
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2023)
Nucleoside- and nucleotide-based therapeutics are indispensable treatment options for patients suffering from malignant and viral diseases. These agents are most commonly administered to patients as prodrugs to maximize bioavailability and efficacy.
Externí odkaz:
https://doaj.org/article/95897a2077a94f00b1666c0194367d18
Autor:
Anatoliy S. Bushnev, Perry W. Bartsch, Savita Sharma, Kyle E. Giesler, Dennis C. Liotta, Eric J. Miller, Madhuri Dasari, D'erasmo Michael, Adriaan E. Basson, Soyon S. Hwang, Akshay Raghuram, Nicole Pribut, Iskandar Sabrina, Samantha L. Burton, Cynthia A. Derdeyn
Publikováno v:
Journal of Medicinal Chemistry. 64:12917-12937
Tenofovir (TFV) is the cornerstone nucleotide reverse transcriptase inhibitor (NtRTI) in many combination antiretroviral therapies prescribed to patients living with HIV/AIDS. Due to poor cell permeability and oral bioavailability, TFV is administere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0fe8f64ae776888f4188d89e13f619a
https://doi.org/10.1021/acs.jmedchem.1c01083
https://doi.org/10.1021/acs.jmedchem.1c01083
Autor:
Traci Legere, Pradeep B. J. Reddy, Korey A. Walter, Bali Pulendran, Prabhu S. Arunachalam, Shankar Subramaniam, Florian Wimmers, Madeleine K D Scott, Celia C. LaBranche, Bertrand Z. Yeung, John P. Vasilakos, Venkata S. Bollimpelli, Samantha L. Burton, Sailaja Gangadhara, Sudhir Pai Kasturi, Shakti Gupta, Cynthia A. Derdeyn, Caroline Petitdemange, Pamela A. Kozlowski, David C. Montefiori, Tiffany M. Styles, Thomas J. Ketas, John P. Moore, Chil Yong Kang, Rama Rao Amara, Eric Hunter, George M. Shaw, Purvesh Khatri, Mark A. Tomai, Anthony Tsai, David Masopust, Vineet Joag, Clare F. Quarnstrom, Tysheena P. Charles
Publikováno v:
Nature Medicine
Recent efforts toward an HIV vaccine focus on inducing broadly neutralizing antibodies, but eliciting both neutralizing antibodies (nAbs) and cellular responses may be superior. Here, we immunized macaques with an HIV envelope trimer, either alone to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ad3f6afa379c5c408d930aefb7aaee
https://doi.org/10.1038/s41591-020-0858-8
https://doi.org/10.1038/s41591-020-0858-8
Autor:
Edgars Jecs, Yesim A. Tahirovic, Robert J. Wilson, Eric J. Miller, Michelle Kim, Valarie Truax, Huy H. Nguyen, Nicholas S. Akins, Manohar Saindane, Tao Wang, Chi S. Sum, Mary E. Cvijic, Gretchen M. Schroeder, Samantha L. Burton, Cynthia A. Derdeyn, Lingjie Xu, Yi Jiang, Lawrence J. Wilson, Dennis C. Liotta
Publikováno v:
Journal of medicinal chemistry. 65(5)
Our first-generation CXCR4 antagonist TIQ15 was rationally modified to improve drug-like properties. Introducing a nitrogen atom into the aromatic portion of the tetrahydroisoquinoline ring led to several heterocyclic variants including the 5,6,7,8-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b393ed15a5b53abcfd5ac6f12274c8e4
https://pubmed.ncbi.nlm.nih.gov/35179893
https://pubmed.ncbi.nlm.nih.gov/35179893
Autor:
Bali Pulendran, Traci Legere, Tiffany M. Styles, Peter T. Hraber, Lori M Spicer, Pradeep B. J. Reddy, Tysheena P. Charles, Cynthia A. Derdeyn, Sailaja Gangadhara, Vijayakumar Velu, Sudhir Pai Kasturi, Eric Hunter, Samantha L. Burton, Rama Rao Amara
Publikováno v:
Journal of Virology. 93
The goals of preclinical HIV vaccine studies in nonhuman primates are to develop and test different approaches for their ability to generate protective immunity. Here, we compared the impact of 7 different vaccine modalities, all expressing the HIV-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9562ced10010326b719faf68d0b0e6d2
https://doi.org/10.1128/jvi.01846-18
https://doi.org/10.1128/jvi.01846-18
Autor:
S. Abigail Smith, Samantha L. Burton, William Kilembe, Shabir Lakhi, Etienne Karita, Matt Price, Susan Allen, Cynthia A. Derdeyn
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 9 (2019)
Frontiers in Immunology, Vol 9 (2019)
Multiple antibody effector functions arise in HIV-1 infection that could be harnessed to protect against infection or clear the persistent reservoir. Here, we have investigated the genetic and functional memory B cell and antibody landscape present d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::317ef4d33aa9140f82726aa3de4a927c
Autor:
Christopher A. Cottrell, Eric Hunter, L.M. Sewall, Venkata S. Bollimpelli, Prabhu S. Arunachalam, Tysheena P. Charles, Cynthia A. Derdeyn, Rama Rao Amara, Sailaja Gangadhara, Marit J. van Gils, Samantha L. Burton, George M. Shaw, Andrew B. Ward, Antu K. Dey, Bali Pulendran
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009257 (2021)
PLoS Pathogens
PLoS pathogens, 17(2):e1009257. Public Library of Science
PLoS Pathogens
PLoS pathogens, 17(2):e1009257. Public Library of Science
Stabilized HIV-1 envelope (Env) trimers elicit tier 2 autologous neutralizing antibody (nAb) responses in immunized animals. We previously demonstrated that BG505 SOSIP.664.T332N gp140 (BG505 SOSIP) immunization of rhesus macaques (RM) provided robus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83d5aae89199ec88663ec2eec961cdb7
https://doi.org/10.1371/journal.ppat.1009257
https://doi.org/10.1371/journal.ppat.1009257